Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel G Hayward"'
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100692 (2014)
During mitosis large alterations in cellular structures occur rapidly, which to a large extent is regulated by post-translational modification of proteins. Modification of proteins with the small ubiquitin-related protein SUMO2/3 regulates mitotic pr
Externí odkaz:
https://doaj.org/article/4dfaa8b095bb4081a91ab08bd2458099
Autor:
Marianne Terndrup Pedersen, Susanne M. Kooistra, Anne Laugesen, Daniel G. Hayward, Kristian Helin, Jens Vilstrup Johansen, Aliaksandra Radzisheuskaya, Karl Agger, Jakob Nilsson
Publikováno v:
The EMBO Journal, 35(14), 1550-1564. Wiley
Chromatin-associated proteins are essential for the specification and maintenance of cell identity. They exert these functions through modulating and maintaining transcriptional patterns. To elucidate the functions of the Jmjd2 family of H3K9/H3K36 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c18726731e0b3a32e62f1c995eb42c
https://research.rug.nl/en/publications/a35661a4-c778-4c25-bf8c-af96160608ac
https://research.rug.nl/en/publications/a35661a4-c778-4c25-bf8c-af96160608ac
Autor:
Garry G Sedgwick, Barbara Di Fiore, Jakob Nilsson, Lu Yu, Mercedes Pardo, Jonathon Pines, Daniel G. Hayward
Publikováno v:
The EMBO Journal. 32:303-314
The Anaphase Promoting Complex/Cyclosome (APC/C) in complex with its co-activator Cdc20 is responsible for targeting proteins for ubiquitin-mediated degradation during mitosis. The activity of APC/C-Cdc20 is inhibited during prometaphase by the Spind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3706d18a434b8f9cb2820c6fd6d20da5
https://doi.org/10.1038/emboj.2012.335
https://doi.org/10.1038/emboj.2012.335
Autor:
Navdeep K. Sahota, Samantha Burns, Daniel G. Hayward, Guojie Mao, Paul Workman, Ian Collins, Eilis Byrne, Lisa Pickard, Yvette Newbatt, Wynne Aherne, Andrew M. Fry
Publikováno v:
SLAS Discovery. 15:918-927
Nek2 is a serine/threonine protein kinase that localizes to the centrosome and is implicated in mitotic regulation. Overexpression of Nek2 induces premature centrosome separation and nuclear defects indicative of mitotic errors, whereas depletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1905cc4756330a37326dfb364ad6bbdd
https://doi.org/10.1177/1087057110376537
https://doi.org/10.1177/1087057110376537
Autor:
Eleanor M. Ford, Wenjuan Wu, Andrew M. Fry, Daniel G. Hayward, Axel Knebel, Joanne E. Baxter, Margarida Fardilha, Edgar F. da Cruz e Silva, Samantha L. Wattam
Publikováno v:
Journal of Biological Chemistry. 282:26431-26440
Nek2 is a cell cycle-regulated serine/threonine protein kinase that is up-regulated in human cancers. Functionally, it is implicated in control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44c4fecc314a9da571e8da5f33648f6
https://doi.org/10.1074/jbc.m704969200
https://doi.org/10.1074/jbc.m704969200
Publikováno v:
Nature Communications
The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by delaying anaphase onset in response to unattached kinetochores. Checkpoint signalling requires the kinetochore localization of the Mad1–Mad2 complex that in more complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba82d3eefd5b78f87ae1bf54dc88294
http://europepmc.org/articles/PMC4458899
http://europepmc.org/articles/PMC4458899
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100692 (2014)
PLoS ONE
PLoS ONE
During mitosis large alterations in cellular structures occur rapidly, which to a large extent is regulated by post-translational modification of proteins. Modification of proteins with the small ubiquitin-related protein SUMO2/3 regulates mitotic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce1a1196ee83babecead804c126f3f0
http://europepmc.org/articles/PMC4074068?pdf=render
http://europepmc.org/articles/PMC4074068?pdf=render
Autor:
Iain M. Hagan, Robert Clarke, Alison J. Faragher, Daniel G. Hayward, Meenu R. Pillai, Andrew M. Fry
Publikováno v:
Cancer research. 64(20)
Aneuploidy and chromosome instability are common abnormalities in human cancer. Loss of control over mitotic progression, multipolar spindle formation, and cytokinesis defects are all likely to contribute to these phenotypes. Nek2 is a cell cycle-reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13e3ab4db4997281d17690abf040360
https://pubmed.ncbi.nlm.nih.gov/15492258
https://pubmed.ncbi.nlm.nih.gov/15492258
Autor:
Javier F. Cáceres, Stephen H. Munroe, Adrian R. Krainer, Olga V. Makarova, Daniel G. Hayward, Ian C. Eperon, Akila Mayeda
The first component known to recognize and discriminate among potential 5' splice sites (5'SSs) in pre-mRNA is the U1 snRNP. However, the relative levels of U1 snRNP binding to alternative 5'SSs do not necessarily determine the splicing outcome. Stri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4de4dff87e14bbd0a3b1ee6d696c223
https://europepmc.org/articles/PMC102138/
https://europepmc.org/articles/PMC102138/
