Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel G Bisson"'
Publikováno v:
eLife, Vol 9 (2020)
Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain. Here, we found that RG-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent IVD cells through apoptosis. Gene expressio
Externí odkaz:
https://doaj.org/article/e0bd89ba0da14d62a8909aa653431942
Autor:
Emerson Krock, Jean Ouellet, Daniel G Bisson, Kai Sheng, Neil Saran, Semsi Kocabas, Alisson Teles, Lisbet Haglund
Publikováno v:
Journal of Cellular and Molecular Medicine
Facet joint osteoarthritis is prevalent in young patients with adolescent idiopathic scoliosis (AIS) and might contribute to back pain. Toll‐like receptors (TLR) have been linked to cartilaginous tissue degeneration but their involvement in facet j
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain. Here, we found that RG-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent IVD cells through apoptosis. Gene expressio
Autor:
Alfredo Ribeiro-da-Silva, Kjetil Ask, Jean Ouellet, Rikard Blunck, Daniel G Bisson, Francina Agosti, Reza Sharif-Naeini, Tarheen Fatima, Laura S. Stone, Lou Beaulieu-Laroche, Craig Stanton, Emmanuel Bourinet, Amanda MacPherson, Mary Jo Smith, Kate Poole, Stephanie Mouchbahani-Constance, Annmarie Donoghue, Connor Dietz, Lisbet Haglund, Jonathan Samson, Hugues Petitjean, Marine Christin, Noosha Yousefpour, Uzair Khan, Albena Davidova, Élise Faure
Publikováno v:
Cell
Cell, Elsevier, 2020, 180 (5), pp.956-967.e17. ⟨10.1016/j.cell.2020.01.033⟩
Cell, Elsevier, 2020, 180 (5), pp.956-967.e17. ⟨10.1016/j.cell.2020.01.033⟩
Mechanotransduction, the conversion of mechanical stimuli into electrical signals, is a fundamental process underlying essential physiological functions such as touch and pain sensing, hearing, and proprioception. Although the mechanisms for some of
Publikováno v:
Journal of Clinical Medicine
Journal of Clinical Medicine; Volume 8; Issue 4; Pages: 433
Journal of Clinical Medicine, Vol 8, Iss 4, p 433 (2019)
Journal of Clinical Medicine; Volume 8; Issue 4; Pages: 433
Journal of Clinical Medicine, Vol 8, Iss 4, p 433 (2019)
Curcumin and o-Vanillin cleared senescent intervertebral disc (IVD) cells and reduced the senescence-associated secretory phenotype (SASP) associated with inflammation and back pain. Cells from degenerate and non-mildly-degenerate human IVD were obta
Autor:
Fahad H. Abduljabbar, Derek H. Rosenzweig, Polly Lama, Lisbet Haglund, Jean Ouellet, Daniel G Bisson, Neil Saran
Publikováno v:
JOR Spine
JOR Spine, Vol 1, Iss 2, Pp n/a-n/a (2018)
JOR Spine, Vol 1, Iss 2, Pp n/a-n/a (2018)
Adolescent idiopathic scoliosis (AIS) is a poorly understood deformity of the thoracolumbar spine which affects the intervertebral discs (IVDs) and the articular facet joints. The knowledge concerning facet joints in this context is very limited, alt
Autor:
J. Brooke Currie, Derek H. Rosenzweig, Lisbet Haglund, Jean Ouellet, Daniel G Bisson, Emerson Krock
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Toll-like receptors (TLR) are activated by endogenous alarmins such as fragmented extracellular matrix compounds found in the degenerating disc. TLRs regulate cytokine, neurotrophin, and protease expression in human disc cells in vitro, and thus cont
Autor:
Daniel G. Bisson, Polly Lama, Fahad Abduljabbar, Derek H. Rosenzweig, Neil Saran, Jean A. Ouellet, Lisbet Haglund
Publikováno v:
JOR Spine, Vol 1, Iss 2, Pp n/a-n/a (2018)
Adolescent idiopathic scoliosis (AIS) is a poorly understood deformity of the thoracolumbar spine which affects the intervertebral discs (IVDs) and the articular facet joints. The knowledge concerning facet joints in this context is very limited, alt
Externí odkaz:
https://doaj.org/article/f667d4ae7f5143f193757231733e88c0