Výsledky vyhledávání - "Daniel Forler"

Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition

Autor: Johannes Kreuzer, Stephan A. Sieber, Daniel Forler, Nina C. Bach

Publikováno v: Chemical Science. 6:237-245

Acivicin is a natural product with diverse biological activities. Several decades ago its clinical application in cancer treatment was explored but failed due to unacceptable toxicity. The causes behind the desired and undesired biological effects ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80568e893ae504b85bc7893df1a7704
https://doi.org/10.1039/c4sc02339k

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An efficient protein complex purification method for functional proteomics in higher eukaryotes

Autor: Daniel Forler, Michaela Rode, Elisa Izaurralde, Thomas Köcher, Mark Gentzel, Matthias Wilm

Publikováno v: Nature Biotechnology. 21:89-92

The ensemble of expressed proteins in a given cell is organized in multiprotein complexes1,2. The identification of the individual components of these complexes is essential for their functional characterization. The introduction of the 'tandem affin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cb09ad0cd431ceea9344354793c164e
https://doi.org/10.1038/nbt773

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The protein Mago provides a link between splicing and mRNA localization

Autor: Isabelle C. Braun, Hervé Le Hir, Daniel Forler, David Gatfield, Elisa Izaurralde

Publikováno v: EMBO reports. 2:1119-1124

The proteins Mago and Y14 are evolutionarily conserved binding partners. Y14 is a component of the exon–exon junction complex (EJC), deposited by the spliceosome upstream of messenger RNA (mRNA) exon–exon junctions. The EJC is implicated in post-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f1be806b874884b9331fec0f2da2d6
https://doi.org/10.1093/embo-reports/kve245

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Abstract 2836: Development of a companion diagnostic IHC assay for the biomarker-driven selection of C4.4a positive patients

Autor: Lars Linden, Khusru Asadullah, Sabine Wittemer-Rump, Matthew Nelson, Ulf Forssmann, Thomas Krahn, Joseph R. Couto, Joerg Willuda, Claudia Schneider, Yifei Zhu, Daniel Forler, Zhiming Liao, Alton Hiscox, Robert Pytela, Ricarda Finnern

Publikováno v: Cancer Research. 74:2836-2836

C4.4a (LYPD3), a GPI-anchored cell surface protein, has been identified previously as a cancer- and metastasis-associated cell surface protein. It is expressed in a variety of cancer indications and, particularly, in the squamous cell subtype of non-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::331febcf2f8f3599685f78bfef8c8449
https://doi.org/10.1158/1538-7445.am2014-2836

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RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export

Autor: Ricarda Niggeweg, Gwénaël Rabut, Andrea Herold, Francesca D. Ciccarelli, Jan Ellenberg, Peer Bork, Elisa Izaurralde, Thomas Köcher, Daniel Forler

Publikováno v: Molecular and cellular biology. 24(3)

Metazoan NXF1-p15 heterodimers promote the nuclear export of bulk mRNA across nuclear pore complexes (NPCs). In vitro, NXF1-p15 forms a stable complex with the nucleoporin RanBP2/Nup358, a component of the cytoplasmic filaments of the NPC, suggesting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb596de80c3a0b0005ca1d4e24db0cd4
https://pubmed.ncbi.nlm.nih.gov/14729961

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Elektronická kniha

Dr. Holl 1909 - Arztroman : Ich weiß nicht mehr, was früher war

Autor: Katrin Kastell

Endlich schlägt Dr. Renate Sanders die Augen auf. Verwirrt sieht sie sich in dem Krankenzimmer um. Ihr Blick streift Dr. Holl und ihren Freund Daniel Forler. Die beiden atmen hörbar aus, die beliebte Kinderärztin ist aus dem Koma erwacht. Aber die