Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Daniel Feurstein"'
Autor:
Stefan Altaner, Jonathan Puddick, Valerie Fessard, Daniel Feurstein, Ivan Zemskov, Valentin Wittmann, Daniel R. Dietrich
Publikováno v:
Toxins, Vol 11, Iss 7, p 388 (2019)
Cyanobacterial microcystins (MCs), potent serine/threonine-phosphatase inhibitors, pose an increasing threat to humans. Current detection methods are optimised for water matrices with only a few MC congeners simultaneously detected. However, as MC co
Externí odkaz:
https://doaj.org/article/14059bf11f1e4ba59407167aeba8d800
Autor:
YuanYuan Ling, Laura H. Rosenberg, Derek R. Duckett, Victor Quereda, Isabel Adrados, Vanessa Saunders, Daniel Feurstein, Mohammad Fallahi, Marie Lafitte
Publikováno v:
Molecular Pharmacology. 88:962-969
Glioblastoma multiforme (GBM) is the most aggressive and common form of adult brain cancer. Current therapeutic strategies include surgical resection, followed by radiotherapy and chemotherapy. Despite such aggressive multimodal therapy, prognosis re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3330963b7833fe4ce4088ae32249ac06
https://doi.org/10.1124/mol.115.097774
https://doi.org/10.1124/mol.115.097774
Autor:
Youseung Shin, Michael D. Cameron, Derek R. Duckett, Theodore M. Kamenecka, Xinyi Song, Yuan Yuan Ling, Yuanjun He, Daniel Feurstein, Marcel Koenig, Weimin Chen, Li Lin, Romain Noel, Claudia Ruiz
Publikováno v:
Med. Chem. Commun.. 3:238-243
The design and synthesis of a potent series of c-jun N-terminal kinase (JNK2) inhibitors is described. The development and optimization of the 2,4-diaminopyrimidines series was carried out from an earlier in-house kinase inhibitor program. Through th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dcbb159f0aa76b61e9299703bd1f789
https://doi.org/10.1039/c1md00219h
https://doi.org/10.1039/c1md00219h
Autor:
Daniel Feurstein, Alexandra H. Heussner, Kerstin Stemmer, Julia Kleinteich, Daniel R. Dietrich
Publikováno v:
Environmental Health Perspectives
Background Contamination of natural waters by toxic cyanobacteria is a growing problem worldwide, resulting in serious water pollution and human health hazards. Microcystins (MCs) represent a group of > 80 cyclic heptapeptides, mediating cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6cff1245fb3944c94c2547a5caa27d
https://doi.org/10.1289/ehp.0901289
https://doi.org/10.1289/ehp.0901289
Publikováno v:
Biochimica et biophysica acta. 1833(3)
The apoptosis signal-regulating kinase 1 (ASK1) is activated in response to a wide variety of extracellular stressors. Consequently, dysregulation of ASK1 is associated with multiple pathologies. Here, we show that ASK1 translocates from the cytoplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e9eb648c98cece0137e77f2622d77c
https://pubmed.ncbi.nlm.nih.gov/23123190
https://pubmed.ncbi.nlm.nih.gov/23123190
Publikováno v:
Neurodegenerative Diseases-Processes, Prevention, Protection and Monitoring
The apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed serine/threonine protein kinase and one of more than 20 members that make up the triple MAP kinase (MAP3K) family of enzymes. Over the past decade, genetic studies have revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44e39c738a1dafec548b9b81b7337de
https://doi.org/10.5772/28950
https://doi.org/10.5772/28950
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 124(2)
Cyanobacterial microcystins (MCs) represent a toxin group with > 100 variants, requiring active uptake into cells via organic anion–transporting polypeptides, in order to irreversibly inhibit serine/threonine-specific protein phosphatases. MCs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591117556aff850f20b9853cc3972315
https://pubmed.ncbi.nlm.nih.gov/21934130
https://pubmed.ncbi.nlm.nih.gov/21934130
Publikováno v:
Biochemistry. 49(19)
Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine kinase that responds to a plethora of stress-inducing signals. In turn, activation of ASK1 is associated with a number of human pathological conditions, including neurodegenerative dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1d8ca9dfa1d56fd77faa198097813b
https://pubmed.ncbi.nlm.nih.gov/20364819
https://pubmed.ncbi.nlm.nih.gov/20364819
Microcystins (MCs) are naturally occurring cyclic heptapeptides that exhibit hepato-, nephro- and possibly neurotoxic effects in mammals. Organic anion transporting polypeptides (rodent Oatp/human OATP) appear to be specifically required for active u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838dc88a8355a309dadf2b85ed4ebaf1
Publikováno v:
European journal of pharmacology. 572(1)
Pulmonary fibroblast to myofibroblast conversion is a pathophysiological feature of idiopathic pulmonary fibrosis and COPD. This conversion is induced by transforming growth factor (TGF)-beta derived from epithelial cells as well as activated macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e833735cfc68b9d537f3a6485d2cb5b0
https://pubmed.ncbi.nlm.nih.gov/17659276
https://pubmed.ncbi.nlm.nih.gov/17659276