Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Daniel Felsky"'
Autor:
Peter Zhukovsky, Earvin S. Tio, Gillian Coughlan, David A. Bennett, Yanling Wang, Timothy J. Hohman, Diego A. Pizzagalli, Benoit H. Mulsant, Aristotle N. Voineskos, Daniel Felsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These risk factors, such as depression and vascular disease, do not affect all individuals in the same way, li
Externí odkaz:
https://doaj.org/article/b36664d6b38549e59bb345531b88ac85
Autor:
Jonas Rybnicek, Yuxiao Chen, Milos Milic, Earvin S. Tio, JoAnne McLaurin, Timothy J. Hohman, Philip L. De Jager, Julie A. Schneider, Yanling Wang, David A. Bennett, Shreejoy Tripathy, Daniel Felsky, Evelyn K. Lambe
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Changes in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in Alzheimer’s Disease (AD). Protective and cognitive-enhancing roles for the nicotinic α5 subunit have been identified, but this gene
Externí odkaz:
https://doaj.org/article/f374cbbc47054ea0a3ea6f1c0e8deae1
Autor:
Mohamed Abdelhack, Peter Zhukovsky, Milos Milic, Shreyas Harita, Michael Wainberg, Shreejoy J. Tripathy, John D. Griffiths, Sean L. Hill, Daniel Felsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Sleep and depression have a complex, bidirectional relationship, with sleep-associated alterations in brain dynamics and structure impacting a range of symptoms and cognitive abilities. Previous work describing these relationships has provid
Externí odkaz:
https://doaj.org/article/e2c5f86a83694fdcaedf724a777e3369
Autor:
Xinyue Jiang, Clement C. Zai, Kody G. Kennedy, Yi Zou, Yuliya S. Nikolova, Daniel Felsky, L. Trevor Young, Bradley J. MacIntosh, Benjamin I. Goldstein
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract There is a gap in knowledge regarding the polygenic underpinnings of brain anomalies observed in youth bipolar disorder (BD). This study examined the association of a polygenic risk score for BD (BD-PRS) with grey matter structure and white
Externí odkaz:
https://doaj.org/article/a11a72e0b35f45e3a43839d6b62b5970
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2024)
BackgroundTraditional approaches to modeling suicide-related thoughts and behaviors focus on few data types from often-siloed disciplines. While psychosocial aspects of risk for these phenotypes are frequently studied, there is a lack of research ass
Externí odkaz:
https://doaj.org/article/0c107b6efe2243e6a9177da817a63cc3
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299728 (2024)
Understanding the factors that influence smoking cessation among young people is crucial for planning targeted cessation approaches. The objective of this review was to comprehensively summarize evidence for predictors of different smoking cessation
Externí odkaz:
https://doaj.org/article/559af980be9d4d26ab93bd5173082363
Publikováno v:
Discover Mental Health, Vol 3, Iss 1, Pp 1-27 (2023)
Abstract The growing global burden of mental illness has prompted calls for innovative research strategies. Theoretical models of mental health include complex contributions of biological, psychosocial, experiential, and other environmental influence
Externí odkaz:
https://doaj.org/article/e59145da88644efcb1245d17b148dc62
Autor:
Lenora Higginbotham, E. Kathleen Carter, Eric B. Dammer, Rafi U. Haque, Erik C.B. Johnson, Duc M. Duong, Luming Yin, Philip L. De Jager, David A. Bennett, Daniel Felsky, Earvin S. Tio, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
Publikováno v:
Neurobiology of Disease, Vol 186, Iss , Pp 106286- (2023)
Cognitive impairment in the elderly features complex molecular pathophysiology extending beyond the hallmark pathologies of traditional disease classification. Molecular subtyping using large-scale -omic strategies can help resolve this biological he
Externí odkaz:
https://doaj.org/article/db681a365c8c444f89f02508cb1476ce
Autor:
Keon Arbabi, Yiyue Jiang, Derek Howard, Anukrati Nigam, Wataru Inoue, Guillermo Gonzalez-Burgos, Daniel Felsky, Shreejoy J. Tripathy
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107329- (2023)
Summary: Microglia are cells with diverse roles, including the regulation of neuronal excitability. We leveraged Patch-seq to assess the presence and effects of microglia in the local microenvironment of recorded neurons. We first quantified the amou
Externí odkaz:
https://doaj.org/article/5ef8c99d6bcf4b1d979c6859ba7920fc
Autor:
Isabel Kerrebijn, Michael Wainberg, Peter Zhukovsky, Yuxiao Chen, Melanie Davie, Daniel Felsky, Shreejoy J. Tripathy
Publikováno v:
NeuroImage, Vol 276, Iss , Pp 120177- (2023)
Many neuropsychiatric disorders are characterised by altered cortical thickness, but the cell types underlying these changes remain largely unknown. Virtual histology (VH) approaches map regional patterns of gene expression with regional patterns of
Externí odkaz:
https://doaj.org/article/a3303179fffc4c95867b03fb767c1313