Výsledky vyhledávání - "Daniel Fehrenbach"

Time Restricted Feeding Reverses Western Diet-Induced Disruptions in Diurnal Blood Pressure Rhythms and Aortic Media Thickening

Autor: Daniel Fehrenbach, Claudia Edell, Charles Smart, Jean Wassenaar, Bianca Nguyen, Megan Rhoads, David Pollock, Jennifer Pollock, Meena Madhur

Publikováno v: Physiology. 38

Cardiovascular disease is one of the primary contributors to the global burden of disease. A poor diet commonly observed in the western world consisting of elevated fat, salt, and sugar is estimated to contribute to 14% of disability-associated life

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c29398cc8f2b72863518b5dde4d69a95
https://doi.org/10.1152/physiol.2023.38.s1.5733127

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Multi-omics Analyses Identify Galectin-1 as a Potential Novel Mediator of Heart Failure with Preserved Ejection Fraction in Mice and Humans

Autor: Jean Wassenaar, Duncan Smart, Daniel Fehrenbach, Matthew Dungan, Amanda Doran, Megan Shuey, Meena Madhur

Publikováno v: Physiology. 38

Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome where patients present with symptoms of volume overload despite having a normal systolic function. HFpEF is associated with elevation of inflammatory biomarkers, but the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0e6c7c722a9e1743d1c632597ab058a
https://doi.org/10.1152/physiol.2023.38.s1.5735223

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Abstract P237: Mitochondrial GCN5L1 Promotes CypD Acetylation, Oxidative Stress, Endothelial Dysfunction And Hypertension

Autor: Sergey Dikalov, Liliya Tkachuk, Mingfang Ao, Daniel Fehrenbach, Michael Sack, Anna Dikalova

Publikováno v: Hypertension. 79

Nearly half of adult population has hypertension which is a main risk factor for cardiovascular disease. Mitochondrial dysfunction contributes to hypertension and targeting mitochondria can potentially improve treatment of hypertension. We found hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24c8bfae5e3734ed95cf920bdb771d5b
https://doi.org/10.1161/hyp.79.suppl_1.p237

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Abstract 046: Induction Of Endothelial Sirt3 After Onset Of Hypertension Rescues Endothelial Function

Autor: Anna Dikalova, Liliya Tkachuk, Mingfang Ao, Daniel Fehrenbach, Jack Arbiser, Sergey Dikalov

Publikováno v: Hypertension. 79

Endothelial dysfunction plays a key role in the pathogenesis of hypertension and represents a major risk factor for cardiovascular disease. Despite treatment with multiple drugs, only 1 in 4 patients has blood pressure under control. We discovered a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b92c7f7084eb8346c0dc41df57b62613
https://doi.org/10.1161/hyp.79.suppl_1.046

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Abstract P3015: Cite-seq Identifies A Novel Role For Macrophage Trem2 In A Murine Model Of Hfpef

Autor: Charles Smart, Daniel Fehrenbach, Jean J Wassenaar, Vineet Agrawal, Anna R Hemnes, Amanda C Doran, Meena Madhur

Publikováno v: Circulation Research. 131

Deoxycorticosterone acetate (DOCA)-salt is a common model of hypertension and has been used to study heart failure with preserved ejection fraction (HFpEF) in rats. Our goal was to validate DOCA-salt as a mouse model of HFpEF and to identify immune m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::457e32179568a8e2b55facfc24b2da40
https://doi.org/10.1161/res.131.suppl_1.p3015

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Abstract MP50: Time Restricted Feeding Reduces Interleukin 17a Production Associated With Western Diets

Autor: Gwendolyn K Davis, Claudia Edell, Jennifer S. Pollock, Meena S. Madhur, Daniel Fehrenbach, Charles D Smart

Publikováno v: Hypertension. 78

Circadian rhythms govern our daily physiological processes. However, disruption of circadian rhythms, as can occur with ad libitum Western diets, disrupt these processes leading to cardiometabolic diseases. Our lab and others have shown that Th17 cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a7b0b8f013370c903bf523b626552ac
https://doi.org/10.1161/hyp.78.suppl_1.mp50

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Abstract MP04: Interleukin-33 Drives Cardiac Remodeling And Alters Macrophage Polarization In Doca-salt Hypertension

Autor: Meena S. Madhur, R. Stokes Peebles, Matthew Dungan, Amanda C. Doran, Daniel Fehrenbach, Charles D Smart

Publikováno v: Hypertension. 78

Interleukin-33 (IL-33) is an alarmin critical for alternative macrophage activation and has been linked to hypertension in humans. The goal of this study was to evaluate whether IL-33 contributes to (deoxycorticosterone acetate) DOCA-salt induced car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5823a3e3ea2eea758ae0d991ff0b65ca
https://doi.org/10.1161/hyp.78.suppl_1.mp04

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