Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Daniel F. Wyss"'
Autor:
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang
Publikováno v:
Journal of Medicinal Chemistry. 65:16234-16251
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection. Concurrent with our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72a226d0f459e4620537979c8da4d4d
https://doi.org/10.1021/acs.jmedchem.2c00766
https://doi.org/10.1021/acs.jmedchem.2c00766
Autor:
Wonsuk Chang, Michael D. Altman, Charles A. Lesburg, Samanthi A. Perera, Jennifer A. Piesvaux, Gottfried K. Schroeder, Daniel F. Wyss, Saso Cemerski, Yiping Chen, Edward DiNunzio, Andrew M. Haidle, Thu Ho, Ilona Kariv, Ian Knemeyer, Johnny E. Kopinja, Brian M. Lacey, Jason Laskey, Jongwon Lim, Brian J. Long, Yanhong Ma, Matthew L. Maddess, Bo-Sheng Pan, Jeremy P. Presland, Edward Spooner, Dietrich Steinhuebel, Quang Truong, Zhibo Zhang, Jianmin Fu, George H. Addona, Alan B. Northrup, Emma Parmee, James R. Tata, David Jonathan Bennett, Jared N. Cumming, Tony Siu, B. Wesley Trotter
Publikováno v:
Journal of medicinal chemistry. 65(7)
Stereochemically and structurally complex cyclic dinucleotide-based stimulator of interferon genes (STING) agonists were designed and synthesized to access a previously unexplored chemical space. The assessment of biochemical affinity and cellular po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06368ab6dd14d5ea28c031fb685e4dae
https://pubmed.ncbi.nlm.nih.gov/35332774
https://pubmed.ncbi.nlm.nih.gov/35332774
Autor:
Edward R. Zartler, Daniel F. Wyss
Publikováno v:
Structural Biology in Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::251462588e1df5c4070b94db88af5938
https://doi.org/10.1002/9781118681121.ch14
https://doi.org/10.1002/9781118681121.ch14
Autor:
Laura Price, Samanthi A. Perera, Daniel F. Wyss, Johnny E. Kopinja, Saso Cemerski, Sharad K. Sharma, Timothy J. Henderson, Serena Xu, Andrew M. Haidle, Min Lu, George H. Addona, Greg O’Donnell, Berengere Sauvagnat, Gottfried K. Schroeder, Ilona Kariv, Larissa Rakhilina, Sriram Tyagarajan, Bo-Sheng Pan, Hyun Chong Woo, Brian Long, Jared N. Cumming, Brandon Cash, Yiping Chen, Ryan D. Otte, B. Wesley Trotter, Jeremy Presland, Jennifer Piesvaux, Brian M. Lacey, Rui Liang, Peter J. Dandliker, Ellen C. Minnihan, Charles A. Lesburg, Ian Knemeyer, Yanhong Ma, Guo Feng, David Jonathan Bennett, Michael D. Altman, Alexei V. Buevich, Jason Laskey, James P. Jewell, Wonsuk Chang
Publikováno v:
Signal Transduction and Targeted Therapy
Pharmacological activation of the STING (stimulator of interferon genes)-controlled innate immune pathway is a promising therapeutic strategy for cancer. Here we report the identification of MSA-2, an orally available non-nucleotide human STING agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93434b3ed8c750bce8ca979d455db02c
https://doi.org/10.1126/science.aba6098
https://doi.org/10.1126/science.aba6098
Autor:
Brian M. Beyer, Vincent Madison, Eric M. Parker, Mckittrick Brian A, Daniel F. Wyss, William J. Greenlee, Corey Strickland, T. Nechuta, Johannes H. Voigt, John C. Hunter, Mary M. Senior, Andrew Stamford, Matthew E. Kennedy, Michael Czarniecki, Yu-Sen Wang, Elizabeth M. Smith
Publikováno v:
Journal of Medicinal Chemistry. 53:942-950
Fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design were used to identify novel inhibitors for BACE-1. A rapid optimization of an initial NMR hit was achieved by a combination of NMR and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b051b98c57bda77146034e6e18e44c2d
https://doi.org/10.1021/jm901472u
https://doi.org/10.1021/jm901472u
Autor:
Marc A. Labroli, Jing Su, Todd Mayhood, Mark A. McCoy, Payal R. Sheth, Christopher M. Tan, Terry Roemer, Yan Hou, Daniel F. Wyss
Publikováno v:
Journal of biomolecular screening. 21(6)
Nonessential enzymes in the staphylococcal wall teichoic acid (WTA) pathway serve as highly validated β-lactam potentiation targets. MnaA (UDP-GlcNAc 2-epimerase) plays an important role in an early step of WTA biosynthesis by providing an activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c97aee4e4c09aa10bc51d430d4c2c1f
https://pubmed.ncbi.nlm.nih.gov/27028606
https://pubmed.ncbi.nlm.nih.gov/27028606
Autor:
Hai-Young, Kim, Daniel F, Wyss
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1263
Fragment-based drug design (FBDD) comprises both fragment-based screening (FBS) to find hits and elaboration of these hits to lead compounds. Typical fragment hits have lower molecular weight (300-350 Da) and lower initial potency but higher ligand e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04150903de99ed67e5b616c7233bfb49
https://pubmed.ncbi.nlm.nih.gov/25618347
https://pubmed.ncbi.nlm.nih.gov/25618347
Autor:
Hai-Young Kim, Daniel F. Wyss
Publikováno v:
Methods in Molecular Biology ISBN: 9781493922680
Fragment-based drug design (FBDD) comprises both fragment-based screening (FBS) to find hits and elaboration of these hits to lead compounds. Typical fragment hits have lower molecular weight (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::965571aea0790df91917a5c51811497b
https://doi.org/10.1007/978-1-4939-2269-7_16
https://doi.org/10.1007/978-1-4939-2269-7_16
Publikováno v:
Biochemistry. 44:16594-16601
Accumulation of the cytotoxic 40- to 42-residue beta-amyloid peptide represents the primary pathological process in Alzheimer's disease (AD). BACE1 (beta-site APP cleaving enzyme 1) is responsible for the initial required step in the neuronal amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c701efb3e45e07cbcb80f530b5b2f6
https://doi.org/10.1021/bi051040o
https://doi.org/10.1021/bi051040o