Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniel F. Simola"'
Autor:
Daniel F. Simola, Paul Bamborough, Chun-wa Chung, Julio Martin, Robert B. Kirkpatrick, Inmaculada Rioja, Cynthia Tallant, Francisco-Javier Gamo, Félix Calderón, Raquel Gabarró, Chris Larminie, Rab K. Prinjha
Publikováno v:
ACS infectious diseases. 7(11)
This Perspective discusses the published data and recent developments in the research area of bromodomains in parasitic protozoa. Further work is needed to evaluate the tractability of this target class in the context of infectious diseases and launc
Publikováno v:
Molecular Biology and Evolution
Developmental plasticity allows for the remarkable morphological specialization of individuals into castes in eusocial species of Hymenoptera. Developmental trajectories that lead to alternative caste fates are typically determined by specific enviro
Autor:
Hua Yan, Roberto Bonasio, Daniel F. Simola, Juergen Liebig, Shelley L. Berger, Danny Reinberg
Publikováno v:
Annual Review of Entomology. 60:435-452
In eusocial insects, genetically identical individuals can exhibit striking differences in behavior and longevity. The molecular basis of such phenotypic plasticity is of great interest to the scientific community. DNA methylation, as well as other e
Autor:
Daniel F. Simola, Hua Yan, Danny Reinberg, Roberto Bonasio, Shelley L. Berger, Juergen Liebig
Publikováno v:
Nature Reviews Genetics. 15:677-688
Understanding the molecular basis of how behavioural states are established, maintained and altered by environmental cues is an area of considerable and growing interest. Epigenetic processes, including methylation of DNA and post-translational modif
Publikováno v:
Scientific Reports
It is commonly assumed that drug targets are expressed in tissues relevant to their indicated diseases, even under normal conditions. While multiple anecdotal cases support this hypothesis, a comprehensive study has not been performed to verify it. W
Publikováno v:
Genome Biology and Evolution
Orphan genes are defined as genes that lack detectable similarity to genes in other species and therefore no clear signals of common descent (i.e., homology) can be inferred. Orphans are an enigmatic portion of the genome because their origin and fun
Autor:
Shelley L. Berger, Roberto Bonasio, Navdeep S. Mutti, Daniel F. Simola, Juergen Liebig, Danny Reinberg, Kelly Dolezal, Chaoyang Ye
Publikováno v:
Genome Research. 23:486-496
In many ant species, sibling larvae follow alternative ontogenetic trajectories that generate striking variation in morphology and behavior among adults. These organism-level outcomes are often determined by environmental rather than genetic factors.
Autor:
Cristina M. Brady, Roberto Bonasio, Riley Graham, Laurence J. Zwiebel, Claude Desplan, Juergen Liebig, Anandasankar Ray, Danny Reinberg, Shelley L. Berger, Daniel F. Simola, Brittany L. Enzmann
Publikováno v:
Science (New York, N.Y.), vol 351, iss 6268
Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64157d61a120d5410ba6a27848f54863
https://europepmc.org/articles/PMC5057185/
https://europepmc.org/articles/PMC5057185/
Autor:
Todd W. Ridky, Parisha P. Shah, Jiajun Zhu, Morgan A. Sammons, Peter D. Adams, Daniel F. Simola, Christopher A. Natale, Zhixun Dou, Greg Donahue, Jean Dorsey, Taranjit Singh Rai, Brian C. Capell, Shelley L. Berger, Adam M. Drake
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa712d97f06083fc8bb8d2ea248ea0bb
https://eprints.gla.ac.uk/116949/1/116949.pdf
https://eprints.gla.ac.uk/116949/1/116949.pdf
Publikováno v:
Molecular Biology and Evolution. 28:2615-2627
Background. To characterize the genetic basis of phenotypic evolution, numerous studies have identified individual genes that have likely evolved under natural selection. However, phenotypic changes may represent the cumulative effect of similar evol