Výsledky vyhledávání - "Daniel F. Price"

The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition

Autor: Daniel F. Price, Christopher N. Luscombe, Mark Gumbleton, Chris D. Edwards, Peter Eddershaw

Publikováno v: Pharmaceutical Research

Purpose To examine if pulmonary P-glycoprotein (P-gp) is functional in an intact lung; impeding the pulmonary absorption and increasing lung retention of P-gp substrates administered into the airways. Using calculated physico-chemical properties alon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abb25b829f8dc702e0781843e248379
https://pubmed.ncbi.nlm.nih.gov/28702798

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Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout

Autor: Christopher J. Morris, Glyn Taylor, Mathew W. Smith, Peter Eddershaw, Daniel F. Price, Ghaith Aljayyoussi, Chris D. Edwards, Mark Gumbleton, Danielle Francombe

Publikováno v: Journal of Pharmaceutical Sciences. 102:3382-3394

P-glycoprotein (P-gp) mediated efflux is recognised to alter the absorption and disposition of a diverse range of substrates. Despite evidence showing the presence of P-gp within the lung, relatively little is known about the transporter's effect upo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bed12dca31938a7b02f9b3632d2d10d
https://doi.org/10.1002/jps.23587

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Absorption of ipratropium and L-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters

Autor: Christopher J. Morris, John P. Keogh, Mathew W. Smith, Mark Gumbleton, Daniel F. Price, Ghaith Aljayyoussi, Katharina Kreitmeyr

Publikováno v: International Journal of Pharmaceutics

The organic cation transporters OCT and OCTN have been reported to play a significant role in the cellular uptake of substrates within in vitro lung cells. However, no studies to date have investigated the effect of these transporters upon transepith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf584b1cc23ddf10eb68b2e85a62b4eb
https://ueaeprints.uea.ac.uk/id/eprint/55786/

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