Zobrazeno 1 - 10 of 85 pro vyhledávání: '"Daniel F. J. Ketelhuth"'
1
Akademický článek
G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice
Autor: Silke Griepke, Mette Trauelsen, Michelle D. Nilsson, Jakob Hansen, Lasse B. Steffensen, Thue W. Schwartz, Daniel F. J. Ketelhuth
Publikováno v: Cells, Vol 12, Iss 21, p 2580 (2023)
The TCA cycle intermediate metabolite ‘succinate’ has been proposed as an inflammatory mediator, influencing autoimmunity and allergic reactions, through ligation to its sensing receptor SUCNR1/GPR91. Whether GPR91-mediated signalling influences
Externí odkaz: https://doaj.org/article/3fd238d3f65b40cebedba2dd2d78c727
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2
Akademický článek
Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice
Autor: Ashok Kumar Kumawat, Mulugeta M. Zegeye, Geena Varghese Paramel, Roland Baumgartner, Anton Gisterå, Obed Amegavie, Sanna Hellberg, Hong Jin, April S. Caravaca, Leif Å. Söderström, Lindvi Gudmundsdotter, Fredrik Y. Frejd, Liza U. Ljungberg, Peder S. Olofsson, Daniel F. J. Ketelhuth, Allan Sirsjö
Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)
The balance between pro- and anti-inflammatory cytokines released by immune and non-immune cells plays a decisive role in the progression of atherosclerosis. Interleukin (IL)-17A has been shown to accelerate atherosclerosis. In this study, we investi
Externí odkaz: https://doaj.org/article/a008b8877cff40138fe7b07965ae20bc
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3
Akademický článek
Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells
Autor: Karl-Henrik Grinnemo, Marie Löfling, Lubov Nathanson, Roland Baumgartner, Daniel F. J. Ketelhuth, Vladimir Beljanski, Lindsay C. Davies, Cecilia Österholm
Publikováno v: Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-15 (2019)
Abstract Background Mesenchymal stromal cells (MSCs), due to their regenerative and immunomodulatory properties, are therapeutically used for diseases, including heart failure. As early gestational-phase embryonic tissues exhibit extraordinary regene
Externí odkaz: https://doaj.org/article/af3d631c48c044a8aae9b61f60776680
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4
Akademický článek
Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice
Autor: Roland Baumgartner, Felipe B. Casagrande, Randi B. Mikkelsen, Martin Berg, Konstantinos A. Polyzos, Maria J. Forteza, Aastha Arora, Thue W. Schwartz, Siv A. Hjorth, Daniel F. J. Ketelhuth
Publikováno v: Metabolites, Vol 11, Iss 7, p 411 (2021)
G-protein-coupled receptor-35 (GPR35) has been identified as a receptor for the tryptophan metabolite kynurenic acid (KynA) and suggested to modulate macrophage polarization in metabolic tissues. Whether GPR35 can influence vascular inflammation and
Externí odkaz: https://doaj.org/article/1c8d0f2ac729443ca49cd942c48ac63b
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5
Akademický článek
Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice
Autor: Maria J. Forteza, Konstantinos A. Polyzos, Roland Baumgartner, Bianca E. Suur, Marion Mussbacher, Daniel K. Johansson, Andreas Hermansson, Göran K. Hansson, Daniel F. J. Ketelhuth
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
T-cell activation is characteristic during the development of atherosclerosis. While overall T-cell responses have been implicated in disease acceleration, regulatory T cells (Tregs) exhibit atheroprotective effects. The expression of the enzyme indo
Externí odkaz: https://doaj.org/article/8ea87542973648e4934b564803e98872
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8
Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease
Autor: Bianca E, Suur, Melody, Chemaly, Moritz, Lindquist Liljeqvist, Djordje, Djordjevic, Markus, Stenemo, Otto, Bergman, Eva, Karlöf, Mariette, Lengquist, Jacob, Odeberg, Eva, Hurt-Camejo, Per, Eriksson, Daniel F J, Ketelhuth, Joy, Roy, Ulf, Hedin, Michael, Nyberg, Ljubica, Matic
Publikováno v: Frontiers in pharmacology. 13
Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9c9f329dc3815b6cb22851693e3c5d7
https://pubmed.ncbi.nlm.nih.gov/36188622
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9
Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt‐PGC1α‐TFAM signaling‐mediated mitochondrial biogenesis
Autor: Shuijie Li, John Andersson, Daniel F. J. Ketelhuth, Susanne Schlisio, Wangjun Liao, Chunhong Ma, Anton Gisterå, Rickard E. Malmström, Per Olof Berggren, Yanan Min, Yang Sun, Junhao Zhang, Miao Wang, Noah Moruzzi, Nailin Li, Shuai Tan
Publikováno v: Journal of Thrombosis and Haemostasis. 18:2685-2700
Background Cell metabolism drives T cell functions, while platelets regulate overall CD4+ T cell immune responses. Objective To investigate if platelets influence cell metabolism and thus regulate CD4+ T effector memory cell (Tem) responses. Methods
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb1dcd3ab0313efc86b0442237256426
https://doi.org/10.1111/jth.15005
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10
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
Autor: Thue W. Schwartz, Ulf Hedin, Roland Baumgartner, Daniel F. J. Ketelhuth, Siv A. Hjorth, Göran K. Hansson, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, K P Polyzos, Martin Berg, Maria J. Forteza
Publikováno v: Baumgartner, R, Berg, M, Matic, L, Polyzos, K P, Forteza, M J, Hjorth, S A, Schwartz, T W, Paulson-Berne, G, Hansson, G K, Hedin, U & Ketelhuth, D F J 2021, ' Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans ', Journal of Internal Medicine, vol. 289, no. 1, pp. 53-68 . https://doi.org/10.1111/joim.13142
BACKGROUND: The metabolism of tryptophan (Trp) along the kynurenine pathway has been shown to carry strong immunoregulatory properties. Several experimental studies indicate that this pathway is a major regulator of vascular inflammation and influenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a9e69bbb1f76c7a9bbfaee45b3641b
https://doi.org/10.1111/joim.13142
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