Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel F. Hassler"'
Autor:
Sylvie G. Laquerre, Jeffrey R. Jackson, Melody A. Diamond, David Sutton, Mary P. Courtney, Richard R. Gontarek, Gary K. Smith, Daniel F. Hassler, Lenore Madden, Ryan G. Kruger, Symon G. Erskine, Mark C. Richter, Maureen R. Bleam, Aidan G. Gilmartin
Supplementary Tables 1-3 from Distinct Concentration-Dependent Effects of the Polo-like Kinase 1–Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63807349d8c5365b462bb33763b38e0
https://doi.org/10.1158/0008-5472.22378532.v1
https://doi.org/10.1158/0008-5472.22378532.v1
Autor:
Sylvie G. Laquerre, Jeffrey R. Jackson, Melody A. Diamond, David Sutton, Mary P. Courtney, Richard R. Gontarek, Gary K. Smith, Daniel F. Hassler, Lenore Madden, Ryan G. Kruger, Symon G. Erskine, Mark C. Richter, Maureen R. Bleam, Aidan G. Gilmartin
Supplementary Figure Legends 1-4 from Distinct Concentration-Dependent Effects of the Polo-like Kinase 1–Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680e0f17f3ce8cc74f754d82f38def5e
https://doi.org/10.1158/0008-5472.22378538.v1
https://doi.org/10.1158/0008-5472.22378538.v1
Autor:
Sylvie G. Laquerre, Jeffrey R. Jackson, Melody A. Diamond, David Sutton, Mary P. Courtney, Richard R. Gontarek, Gary K. Smith, Daniel F. Hassler, Lenore Madden, Ryan G. Kruger, Symon G. Erskine, Mark C. Richter, Maureen R. Bleam, Aidan G. Gilmartin
Supplementary Figures 1-4 from Distinct Concentration-Dependent Effects of the Polo-like Kinase 1–Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ad8ebae32a794098ee99c407b72872
https://doi.org/10.1158/0008-5472.22378535.v1
https://doi.org/10.1158/0008-5472.22378535.v1
Autor:
Sylvie G. Laquerre, Jeffrey R. Jackson, Melody A. Diamond, David Sutton, Mary P. Courtney, Richard R. Gontarek, Gary K. Smith, Daniel F. Hassler, Lenore Madden, Ryan G. Kruger, Symon G. Erskine, Mark C. Richter, Maureen R. Bleam, Aidan G. Gilmartin
Additions to Supplement Table 3 from Distinct Concentration-Dependent Effects of the Polo-like Kinase 1–Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2382019a7bca7fdff5e1920fcfcedfa6
https://doi.org/10.1158/0008-5472.22378544.v1
https://doi.org/10.1158/0008-5472.22378544.v1
Autor:
Maureen R. Bleam, Mark Richter, Lenore Madden, Mary P. Courtney, David Sutton, Ryan G. Kruger, Sylvie Laquerre, Melody Diamond, Symon G. Erskine, Aidan G. Gilmartin, Jeffrey R. Jackson, Gary K. Smith, Richard R. Gontarek, Daniel F. Hassler
Publikováno v:
Cancer Research. 69:6969-6977
Polo-like kinase 1 (Plk1) is a conserved serine/threonine kinase that plays an essential role in regulating the many processes involved in mitotic entry and progression. In humans, Plk1 is expressed primarily during late G2 and M phases and, in conju
Autor:
Daniel F. Hassler, Robert T. Nolte, Denis Patrick, Jun Tang, Masato Nakano, Kazunori Ozawa, Maureen L. Ho, Eldridge N. Nartey, Yasushi Miyazaki, Yutaka Maeda, Hideyuki Sato, Anne T. Truesdale, Masaki Sugai, Liping Wang, Yuji Okamoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1773-1778
During our effort to develop dual VEGFR2 and Tie-2 inhibitors as anti-angiogenic agents for cancer therapy, we discovered 4-amino-5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)- aminocarbonylamino)phenyl)furo[2,3-d]pyrimidine (8a) possessing strong inhib
Autor:
Victoria B. Knick, Tona M. Gilmer, Daniel F. Hassler, Masaaki Furuta, Randy T. McConnell, Glenn M. Spehar, Nobuhiro Noro, Kyle A. Emmitte, Robert A. Mook, Timothy J. Lansing, Mui Cheung, Derek R. Duckett
Publikováno v:
Molecular Cancer Therapeutics. 6:450-459
Polo-like kinase 1 (PLK1) plays key roles in the regulation of mitotic progression, including mitotic entry, spindle formation, chromosome segregation, and cytokinesis. PLK1 expression and activity are strongly linked to proliferating cells. Many stu
Autor:
Yasuo Okamoto, Lina M. Obeid, Yusuf A. Hannun, Hirofumi Sawai, Chiara Luberto, Daniel F. Hassler, Debra J. Hazen-Martin, Eric E. Boros, Paola Signorelli, Gary K. Smith
Publikováno v:
Journal of Biological Chemistry. 277:41128-41139
A high throughput screen for neutral, magnesium-dependent sphingomyelinase (SMase) was performed. One inhibitor discovered in the screen, GW4869, functioned as a noncompetitive inhibitor of the enzyme in vitro with an IC(50) of 1 microm. It did not i
Publikováno v:
Journal of Biological Chemistry. 273:34472-34479
Sphingomyelin hydrolysis and ceramide generation catalyzed by sphingomyelinases (SMase) are key components of the signaling pathways in cytokine- and stress-induced cellular responses. In this study, we report the partial purification and characteriz
Autor:
Victoria B. Knick, Timothy J. Lansing, C. Webb Andrews, Mui Cheung, Kyle A. Emmitte, James Michael Salovich, Hamilton D. Dickson, David H. Drewry, Jennifer Gabriel Badiang, Kristen Elizabeth Nailor, Holly Kathleen Emerson, James A. Linn, Kevin Wayne Kuntz, Robert A. Mook, Ronda G. Davis-Ward, Glenn M. Spehar, Andrea H. Epperly, Daniel F. Hassler
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.