Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel F. Chollet"'
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 746:311-314
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 21:641-646
A gas chromatography-mass spectrometry assay method suitable for the therapeutic drug monitoring of the antiepileptic drug tiagabine is described. Tiagabine and its desmethylated analogue used as internal standard were first extracted from serum by l
Autor:
Laurent Vernillet, Laurent Goumaz, G. Montay, Alain Renard, David J. Mazzo, Daniel F. Chollet, Valdo Arnera
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 718:163-175
CPT-11 (irinotecan) and mainly its metabolite SN-38 are potent antitumor derivatives of camptothecin. As the active lactone forms of both CPT-11 and SN-38 exist in pH-dependent equilibrium with their respective less potent open-ring hydroxy acid spec
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 683:237-243
The assays of antiepileptic drugs, which are performed by central laboratories in Phase II and III clinical trials, require both a very fast turn-around time and a suitable specificity. In order to decrease the run time and to keep the powerful speci
Autor:
Daniel F. Chollet, M. Salanon
Publikováno v:
Journal of Chromatography A. 593:73-78
An automated chromatographic system, combining solid-phase extraction and automated pre-column exchange, is described for the routine determination of Zy 17617B at the pmol/ml level in human plasma. The sample extraction and elution onto the analytic
Autor:
Daniel F. Chollet
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 767(2)
Current analytical methodologies applied to the determination of antiepileptic drugs in biological material are reviewed. The role of chromatographic techniques is emphasized. Special attention is focused on new chemical entities as well as current t
Publikováno v:
Therapeutic drug monitoring. 22(2)
Summary: A new high-performance liquid chromatography (HPLC) assay method was developed for the therapeutic monitoring of tacrine. The method involved a simple protein precipitation by means of either acetonitrile or cold methanol followed by a fast
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 707(1-2)
A high-performance liquid chromatographic method is described for the determination of dimethindene in human tears. The tear samples were diluted in a 0.01 M hydrochloric acid-n-propanol mixture to prevent the irreversible adsorption of dimethindene.
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 701(1)
A simple, reliable high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of noscapine in human plasma. Noscapine and the internal standard, papaverine were quantitatively extracted from plasma on
Publikováno v:
Journal of chromatography. 629(1)
An automated high-performance liquid chromatographic assay, using on-line solid-phase extraction, is described for the determination of dimethindene in urine. The solid-phase extraction of the sample (1000 μl) and the elution of the drug on to the a