Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel F. Schwarz"'
Autor:
Stefan Blankenberg, Alistair S. Hall, Ralph McGinnis, Peter S. Braund, Alison H. Goodall, Richard J. Dixon, Nilesh J. Samani, Inke R. König, Daniel F Schwarz, Christian Hengstenberg, Andrew Keniry, John R. Thompson, Jeanette Erdmann, François Cambien, Nour Eddine El Mokhtari, Stefan Schreiber, Massimo Mangino, Panos Deloukas, Willem H. Ouwehand, Klaus Stark, Pierre Ducimetière, Marcus Fischer, Laurence Tiret, Andreas Ziegler, Christa Meisinger, Henrike Liptau, H.-Erich Wichmann, Anika Götz, Helen Pollard, David-Alexandre Trégouët, Mohammed J. R. Ghori, Patrick Linsel-Nitschke, Heribert Schunkert, Ludwig A. Hothorn
Publikováno v:
Circulation. 117:1675-1684
Background— Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa3283496703ffdfbbef2c607e91cb3
https://doi.org/10.1161/circulationaha.107.730614
https://doi.org/10.1161/circulationaha.107.730614
Motivation: Genome-wide association (GWA) studies have proven to be a successful approach for helping unravel the genetic basis of complex genetic diseases. However, the identified associations are not well suited for disease prediction, and only a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb85fd7c345e6a5109b2d1e8c07bebb
https://europepmc.org/articles/PMC2894507/
https://europepmc.org/articles/PMC2894507/
Autor:
Nour Eddine El Mokhtari, Diana Rubin, David Altshuler, Laurence Tiret, Philipp S. Wild, Jens Baumert, Stefan Blankenberg, Zouhair Aherrahrou, François Cambien, John R. Thompson, Alistair S. Hall, Jürgen Schrezenmeir, Thomas Meitinger, Harald Klüter, Heribert Schunkert, Willem H. Ouwehand, Andreas Ziegler, Claire Perret, Diego Ardissino, Arnika Kathleen Wagner, Piera Angelica Merlini, Arne Schillert, Luisa Bernardinelli, Arne Schäfer, Christa Meisinger, Roberto Elosua, Stephen G. Ball, Stephen M. Schwartz, Christopher J. O'Donnell, Patrick Linsel-Nitschke, Marcus Fischer, Leena Peltonen, Petra Bruse, David S. Siscovick, Veikko Salomaa, Sekar Kathiresan, Stefan Schreiber, Nilesh J. Samani, Winfried März, David-Alexandre Trégouët, Inke R. König, Jeanette Erdmann, Tanja Zeller, Panos Deloukas, Peter Bugert, Benjamin F. Voight, Ben J Wright, Christian Hengstenberg, Peter S. Braund, Anika Großhennig, Olle Melander, Klaus Stark, H-Erich Wichmann, Anthony J. Balmforth, Daniel F Schwarz, Flora Peyvandi, Annette Peters, Wilfried Renner
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c327cfc20664c3af098086aef0eb3fb2
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/85665
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/85665
Autor:
Andreas Ziegler, Daniel F Schwarz, Silke Szymczak, Bernd-Wolfgang Igl, Riccardo Bellazzi, Christian Fuchsberger, Angelo Nuzzo
Publikováno v:
BMC Proceedings
BMC Proceedings, Vol 1, Iss Suppl 1, p S9 (2007)
BMC Proceedings, Vol 1, Iss Suppl 1, p S9 (2007)
Mutual information (MI) is a robust nonparametric statistical approach for identifying associations between genotypes and gene expression levels. Using the data of Problem 1 provided for the Genetic Analysis Workshop 15, we first compared a quantitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bf3b84063308f8f9d9b45a1b34fd71
https://doi.org/10.1186/1753-6561-1-s1-s9
https://doi.org/10.1186/1753-6561-1-s1-s9
Publikováno v:
BMC Proceedings, Vol 1, Iss Suppl 1, p S59 (2007)
BMC Proceedings
BMC Proceedings
With the development of high-throughput single-nucleotide polymorphism (SNP) technologies, the vast number of SNPs in smaller samples poses a challenge to the application of classical statistical procedures. A possible solution is to use a two-stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d1c226eed6cf51a90c3272c9523f97
http://www.gaworkshop.org/
http://www.gaworkshop.org/
Autor:
Daniel Bayer, Steffen Möller, Jeanette Erdmann, Oliver Hädicke, Daniel F Schwarz, Andreas Ziegler
Publikováno v:
Bioinformatics (Oxford, England). 24(1)
For the analysis of complex polygenic diseases, one does not expect all patients to share the same disease-associated alleles. Not even will disease-causing variations be assigned to the identical sets of genes between patients. However, one does exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d4f808b1400b44ed286b9aef154aa4
https://pubmed.ncbi.nlm.nih.gov/18024970
https://pubmed.ncbi.nlm.nih.gov/18024970
Autor:
Hans H. Stassen, Beate Glaser, Kristine E. Lee, Zhenming Zhao, Anita L. DeStefano, Inke R. König, Sungho Won, Kristin K. Nicodemus, Dumitru Brinza, Wei Jiang, Daniel F Schwarz, Yan V. Sun, Jing Li, Weilang Shi, Alexander Platt, Yin Yao Shugart, Claire Bardel, Chuang Xing Li, Wenyi Wang, Paul Majoram, Yan A. Meng, Zhaohui Cai, Andreas Ziegler, Grace Wahba, Xin Li, Usumah A Zagaar, Shelley B. Bull
Publikováno v:
Genetic Epidemiology
Genetic Epidemiology, Wiley, 2007, 31, pp.S51-S60
Genetic Epidemiology, 2007, 31, pp.S51-S60
Genetic Epidemiology, Wiley, 2007, 31, pp.S51-S60
Genetic Epidemiology, 2007, 31, pp.S51-S60
Genome-wide association studies using thousands to hundreds of thousands of single nucleotide polymorphism (SNP) markers and region-wide association studies using a dense panel of SNPs are already in use to identify disease susceptibility genes and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de024dbcef4193c8f1c05cf2a726e935
https://hal.archives-ouvertes.fr/hal-00698356
https://hal.archives-ouvertes.fr/hal-00698356
Publikováno v:
BMC Proceedings, Vol 3, Iss Suppl 7, p S58 (2009)
BMC Proceedings
BMC Proceedings
Genome-wide association studies have become standard in genetic epidemiology. Analyzing hundreds of thousands of markers simultaneously imposes some challenges for statisticians. One issue is the problem of multiplicity, which has been compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3801da350ac533f2a4eb1987b3541c9c
Publikováno v:
BMC Proceedings
BMC Proceedings, Vol 3, Iss Suppl 7, p S65 (2009)
BMC Proceedings, Vol 3, Iss Suppl 7, p S65 (2009)
Genome-wide association studies (GWAS) have helped to reveal genetic mechanisms of complex diseases. Although commonly used genotyping technology enables us to determine up to a million single-nucleotide polymorphisms (SNPs), causative variants are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d99ee314ef76883d745fa7197bb635
Autor:
Daniel F. Schwarz, Oliver Hädicke, Jeanette Erdmann, Andreas Ziegler, Daniel Bayer, Steffen Möller
Publikováno v:
Bioinformatics; Jan2008, Vol. 24 Issue 1, p146-146, 1p