Zobrazeno 1 - 10
of 429
pro vyhledávání: '"Daniel F McAuley"'
Autor:
A John Simpson, Paul Dark, Katie Booth, Ranjit Lall, Gavin Perkins, Timothy Walsh, Manu Shankar-Hari, David McDonald, Daniel F McAuley, Andrew Conway Morris, Andrew Filby, Ronan McMullan, Thomas P Hellyer, Jonathan Scott, Loredana Trevi, Hannah McNeil, Tom Ewen, Phil Mawson, Gert Boschman, Vesna Melkebeek, Iain J McCullagh, Anthony Rostron
Publikováno v:
BMJ Open, Vol 12, Iss 12 (2022)
Introduction Sepsis is characterised by a dysregulated immune response to infection, with exaggerated pro-inflammatory and anti-inflammatory responses. A predominant immunosuppressive profile affecting both innate and adaptive immune responses is ass
Externí odkaz:
https://doaj.org/article/7992f90891fd486988008a8969434d07
Autor:
Valerie J Page, Leiv Otto Watne, Amanda Heslegrave, Allan Clark, Daniel F McAuley, Robert D Sanders, Henrik Zetterberg
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104043- (2022)
Summary: Background: Delirium predicts poor outcomes, however identifying patients with the worst outcomes is challenging. Plasma neurofilament light protein (NfL) is a sensitive indicator of neuronal damage. We undertook an exploratory observational
Externí odkaz:
https://doaj.org/article/2ee5c0f0b0e04e82a271cb354c0b2fcc
Autor:
Bronagh Blackwood, Kevin P Morris, Joanne Jordan, Lisa McIlmurray, Ashley Agus, Roisin Boyle, Mike Clarke, Christina Easter, Richard G Feltbower, Karla Hemming, Duncan Macrae, Clíona McDowell, Margaret Murray, Roger Parslow, Mark J Peters, Glenn Phair, Lyvonne N Tume, Timothy S Walsh, Daniel F McAuley
Publikováno v:
Health Technology Assessment, Vol 26, Iss 18 (2022)
Background: Daily assessment of patient readiness for liberation from invasive mechanical ventilation can reduce the duration of ventilation. However, there is uncertainty about the effectiveness of this in a paediatric population. Objectives: To det
Externí odkaz:
https://doaj.org/article/7eebbd3065c04edd9304d6d46a5a0e22
Autor:
Pratik Sinha, Alexandra Spicer, Kevin L Delucchi, Daniel F McAuley, Carolyn S Calfee, Matthew M Churpek
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103697- (2021)
Background: Heterogeneity in Acute Respiratory Distress Syndrome (ARDS), as a consequence of its non-specific definition, has led to a multitude of negative randomised controlled trials (RCTs). Investigators have sought to identify heterogeneity of t
Externí odkaz:
https://doaj.org/article/dcd0c2641c8d430e8bbc69ed3dea44b9
Autor:
Manu Shankar-Hari, Shalini Santhakumaran, A Toby Prevost, Josie K Ward, Timothy Marshall, Claire Bradley, Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Michael A Matthay, Jonathan Hackett, Cliona McDowell, John G Laffey, Anthony Gordon, Cecilia M O’Kane, Daniel F McAuley
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 8, Iss 10 (2021)
Background: Sepsis and acute respiratory distress syndrome are two heterogeneous acute illnesses with high risk of death and for which there are many ‘statistically negative’ randomised controlled trials. We hypothesised that negative randomised
Externí odkaz:
https://doaj.org/article/30767f2443254ea8bf2af9cd856187e3
Autor:
Yu Luo, Daniel F McAuley, Catherine R Fulton, Joana Sá Pessoa, Ronan McMullan, Fionnuala T Lundy
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249547 (2021)
Polymicrobial biofilms consisting of fungi and bacteria are frequently formed on endotracheal tubes and may contribute to development of ventilator associated pneumonia (VAP) in critically ill patients. This study aimed to determine the role of early
Externí odkaz:
https://doaj.org/article/2ccb43d6b96a4e03abc268c4a6c7b1ec
Autor:
Anthony C Gordon, Shalini Santhakumaran, Farah Al-Beidh, Robert ML Orme, Gavin D Perkins, Mervyn Singer, Daniel F McAuley, Alexina J Mason, Josie K Ward, Kieran P O’Dea, Timothy Felton, Mary Cross, Janis Best-Lane, Jonas Lexow, Ashley Campbell, Deborah Ashby
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 5, Iss 6 (2018)
Background: In septic shock, cardiovascular resuscitation using catecholamine vasopressors and inotropes is standard therapy, but catecholamines have important side effects. Levosimendan (Simdax®; Orion Pharma, Newbury, UK) is a calcium-sensitising
Externí odkaz:
https://doaj.org/article/0fdb3781dce7473aa22a1e9ace439a37
Autor:
Daniel F McAuley, John G Laffey, Cecilia M O’Kane, Gavin D Perkins, Brian Mullan, Thomas J Trinder, Paul Johnston, Phillip A Hopkins, Andrew J Johnston, Lynn Murphy, Christine McNally, Ashley M Agus, Clíona McDowell, Colette Jackson
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 5, Iss 1 (2018)
Background: Acute lung injury is a common devastating clinical syndrome characterised by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure, and is a major cause of morbidity and mortality. Objective: Thi
Externí odkaz:
https://doaj.org/article/ba69a028a5274f31a5d16133b09c4232
Autor:
Ziming Chen, MSc, Michael O. Harhay, PhD, Eddy Fan, MD, PhD, Anders Granholm, MD, Daniel F. McAuley, MD, Martin Urner, MD, Christopher J. Yarnell, MD, Ewan C. Goligher, MD, PhD, Anna Heath, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 10, p e1152 (2024)
BACKGROUND:. Patients with acute hypoxemic respiratory failure are at high risk of death and prolonged time on the ventilator. Interventions often aim to reduce both mortality and time on the ventilator. Many methods have been proposed for analyzing
Externí odkaz:
https://doaj.org/article/28444fc2973e46d1818dab9cd8cf50bc
Autor:
Orla M. Dunne, S. Lorraine Martin, Gerard P. Sergeant, Daniel F. McAuley, Cecilia M. O’Kane, Brian Button, Lorcan P. McGarvey, Fionnuala T. Lundy
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) which may be modulated by the activity of ion channels pres
Externí odkaz:
https://doaj.org/article/682382957f16462fa3945029172ed352