Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Daniel F A R Dourado"'
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Akademický článek
Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.
Autor: Thomas R Caulfield, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Daniel F A R Dourado, Samuel C Flores, Wolfdieter Springer
Publikováno v: PLoS Computational Biology, Vol 10, Iss 11, p e1003935 (2014)
Loss-of-function mutations in PINK1 or PARKIN are the most common causes of autosomal recessive Parkinson's disease. Both gene products, the Ser/Thr kinase PINK1 and the E3 Ubiquitin ligase Parkin, functionally cooperate in a mitochondrial quality co
Externí odkaz: https://doaj.org/article/f7354ae969fb4bd9aa4f52cf1971f172
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4
Rational Engineering of a Carboxylesterase for the Synthesis of Polyesters for Biomedical Applications
Autor: Armando J. D. Silvestre, Stephanie Paul, Derek J. Quinn, Daniel F. A. R. Dourado, Alexandra T. P. Carvalho, Beatriz C. Almeida, Pedro Figueiredo, Andreia F. Sousa, Thomas S. Moody
Reengineered variants of a hyperthermophilic carboxylesterase with improved product yield in the synthesis of poly(ε-caprolactone) and triblock poly(ε-caprolactone)-co-poly(ethylene glycol)Methods: Quantum Mechanics/Molecular Mechanics Molecular Dy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1959d0c8c26828f5b3f470acfce074dc
https://doi.org/10.26434/chemrxiv.14045915
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5
Why the Flavin Adenine Dinucleotide (FAD) Cofactor Needs To Be Covalently Linked to Complex II of the Electron‐Transport Chain for the Conversion of FADH2 into FAD
Autor: Daniel F. A. R. Dourado, Alexandra T. P. Carvalho, Marcel Swart
Publikováno v: Chemistry-A European Journal, 2018, vol. 24, núm. 20, p. 5246-5252
Articles publicats (D-Q)
DUGiDocs – Universitat de Girona
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A covalently bound flavin cofactor is predominant in the succinate-ubiquinone oxidoreductase (SQR; Complex II), an essential component of aerobic electron transport, and in the menaquinol-fumarate oxidoreductase (QFR), the anaerobic counterpart, alth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0193d98eb864263c70f8dc770d56cb7
https://hdl.handle.net/2072/373074
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6
Enzymatic Synthesis of Polyesters: A QM/MM Study
Autor: Pedro Figueiredo, Daniel F. A. R. Dourado, Beatriz C. Almeida, Andreia F. Sousa, Armando J. D. Silvestre, Alexandra T. P. Carvalho
Plastic pollution is causing an immeasurable damage to marine and land eco-systems. Better alternatives are actively being sought-after, such as biodegradable polyesters obtained by enzymatic synthesis. However, wild type enzymes still pose fundament
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1d3e4bcc4baac059bb6b6141dbf794
https://doi.org/10.26434/chemrxiv.9638270
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7
Insights from engineering the Affibody-Fc interaction with a computational-experimental method
Autor: Anders Virtanen, U. Helena Danielson, Mohammad Reza Housaindokht, Olle Nordesjö, Sara Marie Øie Solbak, Daniel F. A. R. Dourado, Ken G. Andersson, Mikael Nissbeck, John Löfblom, Samuel C. Flores, Masoumeh Nosrati
Publikováno v: Protein Engineering, Design and Selection. 30:593-601
The interaction between the Staphylococcal Protein A (SpA) domain B (the basis of the Affibody) molecule and the Fc of IgG is key to the use of Affibodies in affinity chromatography and in potential therapies against certain inflammatory diseases. De
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c5aca5ad42c498a4412956f0022a50
https://doi.org/10.1093/protein/gzx023
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8
Mechanism of Phosphatidylglycerol Activation Catalyzed by Prolipoprotein Diacylglyceryl Transferase
Autor: Iain C. Sutcliffe, Meilan Huang, Daniel F. A. R. Dourado, Munir Bilal, Derek J. Quinn, Warispreet Singh, Thomas S. Moody, James McClory
Publikováno v: Singh, W, Bilal, M, McClory, J, Dourado, D, Quinn, D, Moody, T S, Stucliffe, I & Huang, M 2019, ' Mechanism of Phosphatidylglycerol Activation Catalyzed by Prolipoprotein Diacylglyceryl Transferase ', J. Phys. Chem. B, vol. 123, no. 33, pp. 7092-7102 . https://doi.org/10.1021/acs.jpcb.9b04227
Lipoproteins are essential for bacterial survival. Bacterial lipoprotein biosynthesis is accomplished by sequential modification by three enzymes in the inner membrane, all of which are emerging antimicrobial targets. The X-ray crystal structure of p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53f8afd5b8309cf5c0e2550d59320ab
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9
SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations
Autor: Carla Cristina Marques de Oliveira, Joana Soares, Maria João Romão, Sara Gomes, Filipa Marcelo, Margarida Bastos, Valentina Barcherini, Lucília Domingues, Helena Ramos, Daniel F. A. R. Dourado, Gilberto Fronza, A. Gomes, Maria M. M. Santos, Benedita A. Pinheiro, Ana Luísa Carvalho, Paola Monti, Lucília Saraiva, Alexandra T. P. Carvalho, Joana B. Loureiro
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Background Half of human cancers harbour TP53 mutations that render p53 inactive as a tumor suppressor. As such, reactivation of mutant (mut)p53 through restoration of wild-type (wt)-like function represents one of the most promising therapeutic stra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799b34ae7a024c01f6da659bfba50226
https://pubmed.ncbi.nlm.nih.gov/31536751
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10
Spatial requirement for PAMO for transformation of non-native linear substrates
Autor: Timofey Skvortsov, Miguel de Abreu, Daniel F. A. R. Dourado, Meilan Huang, Alexandra T. P. Carvalho, Lyndsey J. Ferguson, Thomas S. Moody, Derek J. Quinn
Publikováno v: Physical chemistry chemical physics : PCCP. 20(4)
Phenylacetone monooxygenase is the most stable and thermo-tolerant member of the Baeyer–Villiger monooxygenases family, and therefore it is an ideal candidate for the synthesis of industrially relevant ester or lactone compounds. However, its limit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fa52a6c15f327cab46bc480e2f6cb2
https://pubmed.ncbi.nlm.nih.gov/29318252
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