Zobrazeno 1 - 10
of 429
pro vyhledávání: '"Daniel F, McAuley"'
Autor:
Ziming Chen, MSc, Michael O. Harhay, PhD, Eddy Fan, MD, PhD, Anders Granholm, MD, Daniel F. McAuley, MD, Martin Urner, MD, Christopher J. Yarnell, MD, Ewan C. Goligher, MD, PhD, Anna Heath, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 10, p e1152 (2024)
BACKGROUND:. Patients with acute hypoxemic respiratory failure are at high risk of death and prolonged time on the ventilator. Interventions often aim to reduce both mortality and time on the ventilator. Many methods have been proposed for analyzing
Externí odkaz:
https://doaj.org/article/28444fc2973e46d1818dab9cd8cf50bc
Autor:
Orla M. Dunne, S. Lorraine Martin, Gerard P. Sergeant, Daniel F. McAuley, Cecilia M. O’Kane, Brian Button, Lorcan P. McGarvey, Fionnuala T. Lundy
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) which may be modulated by the activity of ion channels pres
Externí odkaz:
https://doaj.org/article/682382957f16462fa3945029172ed352
Autor:
Neil Cody, MB, ChB, Ian Bradbury, PhD, Ross R. McMullan, MB, ChB, Gerard Quinn, RN, Aisling O’Neill, RN, Kathryn Ward, RN, Justine McCann, RN, Daniel F. McAuley, MD, Jonathan A. Silversides, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 5, p e1094 (2024)
OBJECTIVES:. Near-infrared spectroscopy (NIRS) is a potentially valuable modality to monitor the adequacy of oxygen delivery to the brain and other tissues in critically ill patients, but little is known about the physiologic determinants of NIRS-der
Externí odkaz:
https://doaj.org/article/c9190e9d9223405b8e3a1ad1565ee2e5
Autor:
Brian W. Johnston, MD, Andrew A. Udy, MD, PhD, Daniel F. McAuley, MD, Martin Mogk, Dipl.-Math, Ingeborg D. Welters, MD, PhD, Stephanie Sibley, MD, SM
Publikováno v:
Critical Care Explorations, Vol 6, Iss 4, p e1069 (2024)
OBJECTIVES:. To evaluate the current management of new-onset atrial fibrillation and compare differences in practice regionally. DESIGN:. Cross-sectional survey. SETTING:. United States, Canada, United Kingdom, Europe, Australia, and New Zealand. SUB
Externí odkaz:
https://doaj.org/article/8b6fccf7e5fc44e3832648150e1f1b67
Autor:
Peter J. McGuigan, MB, BCh, BAO, MRCA, FFICM, Emma M. Bowcock, MBBS (Hons), FCICM, Nicholas A. Barrett, FCICM, Bronagh Blackwood, PhD, Andrew J. Boyle, PhD, MRCP, Andrew J. Cadamy, MBChB, FRCA, FFICM, Luigi Camporota, MD, PhD, FRCP, FFICM, FERS, John Conlon, BSc, Matthew E. Cove, MB ChB, Michael A Gillies, MD, FRCA, FRCP, FFICM, Clíona McDowell, MSc, CSTAT, James J. McNamee, MB ChB, Cecilia M. O’Kane, PhD, Alex Puxty, MB ChB, FRCA, MRCP, DICM, FFICM, Malcolm Sim, MD, Rebecca Parsons-Simmonds, BSE, MSc, BSc, Tamas Szakmany, PhD, EDIC, DESA, FRCA, FFICM, FCCM, Neil Young, MBChB, MRCP, FRCA, FFICM, Sam Orde, MBBS, PhD, FCICM, Daniel F. McAuley, MD, FMedSci
Publikováno v:
Critical Care Explorations, Vol 6, Iss 1, p e1028 (2024)
OBJECTIVES:. Lower tidal volume ventilation (targeting 3 mL/kg predicted body weight, PBW) facilitated by extracorporeal carbon dioxide removal (ECCO2R) has been investigated as a potential therapy for acute hypoxemic respiratory failure (AHRF) in th
Externí odkaz:
https://doaj.org/article/5bedbd7c4d664c03bfd82002486052e4
Autor:
Shaun M. Pienkos, Andrew R. Moore, Jiazhen Guan, Joseph E. Levitt, Michael A. Matthay, Rebecca M. Baron, John Conlon, Daniel F. McAuley, Cecilia M. O’Kane, Angela J. Rogers
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-9 (2023)
Abstract Background Two acute respiratory distress syndrome (ARDS) trials showed no benefit for statin therapy, though secondary analyses suggest inflammatory subphenotypes may have a differential response to simvastatin. Statin medications decrease
Externí odkaz:
https://doaj.org/article/65d6714ebc4c4cc289e1fce88f12a77f
Autor:
Rejina Mariam Verghis, Cliona McDowell, Bronagh Blackwood, Bohee Lee, Daniel F. McAuley, Mike Clarke
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background Over recent decades, improvements in healthcare have reduced mortality and morbidity rates in many conditions. This has resulted, in part, from the identification of effective interventions in randomised trials, and in conducting
Externí odkaz:
https://doaj.org/article/6c49388e7c73418d860c1053f2c43a0e
Autor:
Andrew James Boyle, Peter Ferris, Ian Bradbury, John Conlon, Manu Shankar-Hari, Angela J. Rogers, Cecilia M. O’Kane, Daniel F. McAuley
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-8 (2022)
Abstract Background Interleukin (IL)-18 is a marker of inflammasome activation, and high baseline plasma IL-18 is associated with increased mortality in patients with sepsis-induced ARDS. The aim of this analysis was to determine if simvastatin was a
Externí odkaz:
https://doaj.org/article/ace2c777a9024f91bfe027b49ebdca6b
Autor:
Ellen Gorman, Manu Shankar-Hari, Phil Hopkins, William S. Tunnicliffe, Gavin D. Perkins, Jonathan Silversides, Peter McGuigan, Colette Jackson, Roisin Boyle, Jamie McFerran, Cliona McDowell, Christina Campbell, Margaret McFarland, Jon Smythe, Jacqui Thompson, Barry Williams, Gerard Curley, John G. Laffey, Mike Clarke, Daniel F. McAuley, Cecilia O’Kane
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Mesenchymal stromal cells (MSCs) may be of benefit in ARDS due to immunomodulatory and reparative properties. This trial investigates a novel CD362 enriched umbilical cord derived MSC product (REALIST ORBCEL-C), produced to Good M
Externí odkaz:
https://doaj.org/article/b39f86b9bd8d43d5a0df92ee016b7c98
Autor:
Lieuwe D. J. Bos, John G. Laffey, Lorraine B. Ware, Nanon F. L. Heijnen, Pratik Sinha, Brijesh Patel, Matthieu Jabaudon, Julie A. Bastarache, Daniel F. McAuley, Charlotte Summers, Carolyn S. Calfee, Manu Shankar-Hari
Publikováno v:
Intensive Care Medicine Experimental, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract The pathophysiology of acute respiratory distress syndrome (ARDS) includes the accumulation of protein-rich pulmonary edema in the air spaces and interstitial areas of the lung, variable degrees of epithelial injury, variable degrees of endo
Externí odkaz:
https://doaj.org/article/fad620f2f499480ea3fef0fa2c2f26b5