A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine

Autor: Amparo Sanz-Marco, Daniel Esperilla, Marc Montesinos-Magraner, Carlos Vila, M. Carmen Muñoz, José R. Pedro, Gonzalo Blay

Publikováno v: Sanz Marco, Amparo Esperilla, Daniel Montesinos Magraner, Marc Vila Descals, Carlos Muñoz, M. Carmen Pedro, José Ramón Blay Llinares, Gonzalo 2023 A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides Organic & Biomolecular Chemistry 21 2 345 350

A Cu(II)/BOX complex catalyses the enantioselective addition of difluorinated silyl enol ethers to acylpyridine N-oxides. The reaction provides difluorinated chiral tertiary alcohols of great interest in medicinal chemistry. These compounds are obtai

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https://pubmed.ncbi.nlm.nih.gov/36484719