Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel Eng Thiam Teo"'
Autor:
Qin Gong, Kim Robinson, Chenrui Xu, Phuong Thao Huynh, Kelvin Han Chung Chong, Eddie Yong Jun Tan, Jiawen Zhang, Zhao Zhi Boo, Daniel Eng Thiam Teo, Kenneth Lay, Yaming Zhang, John Soon Yew Lim, Wah Ing Goh, Graham Wright, Franklin L. Zhong, Bruno Reversade, Bin Wu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
NLRP1 and CARD8 are two recently described sensor proteins for the human inflammasome complex. Here, the authors present the cryo-EM CARD filament structures of the NLRP1 and CARD8 activating domains, which reveal how NLRP1 and CARD8 discriminate bet
Externí odkaz:
https://doaj.org/article/fb33e8feb690411b8e3bbd80f9119b57
Autor:
Joanne Wei Kay Ku, Supatra Tharinee Marsh, Mui Hoon Nai, Kim Samirah Robinson, Daniel Eng Thiam Teo, Franklin Lei Zhong, Katherine A. Brown, Thiam Chye Lim, Chwee Teck Lim, Yunn-Hwen Gan
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 2326-2339 (2021)
Melioidosis is a serious infectious disease endemic in Southeast Asia, Northern Australia and has been increasingly reported in other tropical and subtropical regions in the world. Percutaneous inoculation through cuts and wounds on the skin is one o
Externí odkaz:
https://doaj.org/article/1da7be4843c342dfb7c50daaa36cb5e0
Autor:
Qin Gong, Ziqi Long, Franklin L. Zhong, Daniel Eng Thiam Teo, Yibo Jin, Zhan Yin, Zhao Zhi Boo, Yaming Zhang, Jiawen Zhang, Renliang Yang, Shashi Bhushan, Bruno Reversade, Zongli Li, Bin Wu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The pathogen recognition receptors NOD1/2 recognize bacterial cell wall components and signal through their downstream adapter kinase RIP2 via a CARD (Caspase activation and recruitment domain) mediated oligomerization process. Here the authors prese
Externí odkaz:
https://doaj.org/article/c29ed6dc071e4abb9215cc7c527e42b9
Autor:
Yaming Zhang, Franklin L. Zhong, Chenrui Xu, Zhao Zhi Boo, Kim S. Robinson, Bruno Reversade, Daniel Eng Thiam Teo, Kenneth Lay, Jiawen Zhang, Graham D. Wright, John Soon Yew Lim, Eddie Yong Jun Tan, Kelvin Han Chung Chong, Wah Ing Goh, Qin Gong, Phuong Thao Huynh, Bin Wu
Publikováno v:
Nature communications, 12(1):188. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nod-like receptor (NLR) proteins activate pyroptotic cell death and IL-1 driven inflammation by assembling and activating the inflammasome complex. Closely related sensor proteins NLRP1 and CARD8 undergo unique auto-proteolysis-dependent activation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971fea044a57af53224281deaea2a5a9
https://pure.amc.nl/en/publications/structural-basis-for-distinct-inflammasome-complex-assembly-by-human-nlrp1-and-card8(f93492eb-c2e0-49e8-a33d-9316ae5981a5).html
https://pure.amc.nl/en/publications/structural-basis-for-distinct-inflammasome-complex-assembly-by-human-nlrp1-and-card8(f93492eb-c2e0-49e8-a33d-9316ae5981a5).html
Autor:
Franklin L. Zhong, Bruno Reversade, Daniel Eng Thiam Teo, Yibo Jin, Qin Gong, Jiawen Zhang, Zhan Yin, Bin Wu, Zongli Li, Yaming Zhang, Zhao Zhi Boo, Renliang Yang, Long Ziqi, Shashi Bhushan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature communications, 9(1):4993. Nature Publishing Group
Nature Communications
Nature communications, 9(1):4993. Nature Publishing Group
Nature Communications
Signals arising from bacterial infections are detected by pathogen recognition receptors (PRRs) and are transduced by specialized adapter proteins in mammalian cells. The Receptor-interacting-serine/threonine-protein kinase 2 (RIPK2 or RIP2) is such
Autor:
Vincent T. K. Chow, Gee Ann Toh, De Yun Wang, Bijin Veonice Au, Justin Jang Hann Chu, Chrissie Lim, Bruno Reversade, Tian Sheng Lew, Daniel Eng Thiam Teo, Hsiao Hui Ong, Kim S. Robinson, Kenneth Lay, Kai Sen Tan, Franklin L. Zhong
Publikováno v:
Science, 370(6521):eaay2002. American Association for the Advancement of Science
A ligand is located, at long last! Members of the Nod-like receptor (NLR) family act as intracellular sensors of infection. Once they recognize pathogen-associated molecular patterns, they assemble into signaling complexes called inflammasomes, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f5b80bbf5b1f17f30313173eb81257
https://pure.amc.nl/en/publications/enteroviral-3c-protease-activates-the-human-nlrp1-inflammasome-in-airway-epithelia(1746fd11-3a9c-4dd4-9eb2-adaf33736a0d).html
https://pure.amc.nl/en/publications/enteroviral-3c-protease-activates-the-human-nlrp1-inflammasome-in-airway-epithelia(1746fd11-3a9c-4dd4-9eb2-adaf33736a0d).html
Autor:
Kim S. Robinson, John Soon Yew Lim, Franklin L. Zhong, Chenrui Xu, Bin Wu, Bruno Reversade, Daniel Eng Thiam Teo, Jiawen Zhang, Qin Gong, Graham D. Wright, Wah Ing Goh, Yaming Zhang, Zhao Zhi Boo
Nod-like receptor (NLR) proteins activate pyroptotic cell death and IL-1 driven inflammation by assembling and activating the inflammasome complex. Closely related NLR proteins, NLRP1 and CARD8 undergo unique auto-proteolysis-dependent activation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4fe4bb4cd9fbbcea40bf985e8835d4e
https://doi.org/10.1101/2020.06.17.156307
https://doi.org/10.1101/2020.06.17.156307
Autor:
Andrea D'Osualdo, Cassandra R. Harapas, John E. Connolly, Veonice Bijin Au, Bruno Reversade, Daniel Eng Thiam Teo, Chrissie Lim, Kim S. Robinson, Franklin L. Zhong, Richard Hopkins, Kiat-Yi Tan, William Haowei Xie, Chien-Hsiung Yu, Seth L. Masters, Radoslaw M. Sobota, John C. Reed
Publikováno v:
Journal of biological chemistry, 293(49), 18864-18878. American Society for Biochemistry and Molecular Biology Inc.
The inflammasome is a critical molecular complex that activates interleukin-1 driven inflammation in response to pathogen- and danger-associated signals. Germline mutations in the inflammasome sensor NLRP1 cause Mendelian systemic autoimmunity and sk
Autor:
Zhong, Franklin L.1,2,3,4 franklin.zhong@reversade.com, Robinson, Kim2,3, Daniel Eng Thiam Teo1,2,3, Kiat-Yi Tan1, Chrissie Lim1, Harapas, Cassandra R.5, Chien-Hsiung Yu5, Xie, William H.2, Sobota, Radoslaw M.1, Veonice Bijin Au1, Hopkins, Richard1, D'Osualdo, Andrea6, Reed, John C.7, Connolly, John E.1,8,9, Masters, Seth L.5,10, Reversadea, Bruno1,2,11,12,13
Publikováno v:
Journal of Biological Chemistry. 12/7/2018, Vol. 293 Issue 49, p18864-18878. 15p.