Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel Eikel"'
Autor:
Lucy M. Elphick, Nadine Pawolleck, Irina A. Guschina, Leila Chaieb, Daniel Eikel, Heinz Nau, John L. Harwood, Nick J. Plant, Robin S. B. Williams
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 2, Pp 231-240 (2012)
SUMMARY Lipid droplet formation and subsequent steatosis (the abnormal retention of lipids within a cell) has been reported to contribute to hepatotoxicity and is an adverse effect of many pharmacological agents including the antiepileptic drug valpr
Externí odkaz:
https://doaj.org/article/3a73657e951546bea5f1f050cd4bde46
Autor:
Jack Henion, Daniel Eikel, Carol Bason, Marissa Vavrek, Walter A. Korfmacher, Suzie Yeh, Sheri Smith
Publikováno v:
Rapid Communications in Mass Spectrometry. 25:3587-3596
Liquid extraction surface analysis mass spectrometry (LESA-MS) is a novel surface profiling technique that combines micro-liquid extraction from a solid surface with nano-electrospray mass spectrometry. One potential application is the examination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb6991413b5cc843d1acb0ddc35f34e2
https://doi.org/10.1002/rcm.5274
https://doi.org/10.1002/rcm.5274
Autor:
Daniel Eikel, Jack Henion
Publikováno v:
Rapid Communications in Mass Spectrometry. 25:2345-2354
An automated surface-sampling technique called liquid extraction surface analysis (LESA), coupled with infusion nano-electrospray high-resolution mass spectrometry and tandem mass spectrometry (MS/MS), is described and applied to the qualitative dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02270287352a0bd0da81d2f65c80a975
https://doi.org/10.1002/rcm.5107
https://doi.org/10.1002/rcm.5107
Publikováno v:
Drug Metabolism and Disposition. 34:612-620
Structure-activity relationship studies of valproic acid (VPA) derivatives have revealed a quantitative correlation between histone deacetylase (HDAC) inhibition and induction of neural tube defects (NTDs) in the NMRI-exencephaly-mouse model, but thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be071b25556352c94f6a045b2a55039b
https://doi.org/10.1124/dmd.105.008078
https://doi.org/10.1124/dmd.105.008078
Autor:
Hans Wilhelm Doerr, Daniel Eikel, Heinz Nau, Nezira Köhler, Martin Michaelis, Ute Gravemann, Jindrich Cinatl, Alexander Reinisch
Publikováno v:
Biochemical Pharmacology. 68:531-538
Valproic acid (2-propylpentanoic acid, VPA), an effective inhibitor of histone deacetylases (HDAC) is used for the treatment of epilepsia. In this study, structure-activity relationships for the action of structurally modified VPA derivatives on huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8deca210ad629c1a9d4bf3dc604010
https://doi.org/10.1016/j.bcp.2004.04.013
https://doi.org/10.1016/j.bcp.2004.04.013
Autor:
Arnulf Pekrun, Olaf Witt, Sven Mönkemeyer, Sandra Schulze, Daniel Eikel, Gabi Rönndahl, H. Nau
Publikováno v:
American Journal of Hematology. 81:374-376
Pharmacological induction of hemoglobin F expression may be a promising approach for the treatment of beta-thalassemia and sickle cell disease. Valproic acid, a drug frequently used for the treatment of seizure disorders, has been shown to enhance fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16250b644f6cf7c4866709f0cdb92c6
https://doi.org/10.1002/ajh.20575
https://doi.org/10.1002/ajh.20575
Autor:
Jack Henion, Daniel Eikel
Publikováno v:
Mass Spectrometry for Drug Discovery and Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969afb9f334195be07b932871c490719
https://doi.org/10.1002/9781118516157.ch8
https://doi.org/10.1002/9781118516157.ch8
Autor:
Daniel, Eikel, Marissa, Vavrek, Sheri, Smith, Carol, Bason, Suzie, Yeh, Walter A, Korfmacher, Jack D, Henion
Publikováno v:
Rapid communications in mass spectrometry : RCM. 25(23)
Liquid extraction surface analysis mass spectrometry (LESA-MS) is a novel surface profiling technique that combines micro-liquid extraction from a solid surface with nano-electrospray mass spectrometry. One potential application is the examination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::325687401608920baf4b18ed02780651
https://pubmed.ncbi.nlm.nih.gov/22095508
https://pubmed.ncbi.nlm.nih.gov/22095508
Autor:
John L. Harwood, Nadine Pawolleck, Irina A. Guschina, Robin S.B. Williams, Heinz Nau, Nick Plant, Daniel Eikel, Leila Chaieb, Lucy M. Elphick
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 5, Iss 2, Pp 231-240 (2012)
Disease Models & Mechanisms, Vol 5, Iss 2, Pp 231-240 (2012)
SUMMARY Lipid droplet formation and subsequent steatosis (the abnormal retention of lipids within a cell) has been reported to contribute to hepatotoxicity and is an adverse effect of many pharmacological agents including the antiepileptic drug valpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76acfe06a01dd39a01b8a67753e4a18
https://surrey.eprints-hosting.org/239122/
https://surrey.eprints-hosting.org/239122/
Autor:
Johanna Kaltenhäuser, Daniel Eikel, Heinz Nau, Frauke Meyer, Anke Visan, Andrea Seiler, Ralph Pirow, Christian Riebeling, Andreas Luch, Klaus Becker, Birgitta Slawik, Roland Buesen, Horst Spielmann, Jutta Volland
Publikováno v:
Toxicological Sciences
Teratogenicity can be predicted in vitro using the embryonic stem cell test (EST). The EST, which is based on the morphometric measurement of cardiomyocyte differentiation and cytotoxicity parameters, represents a scientifically validated method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a59e2c4f9a950aed8ff7766cc96c62
https://pubmed.ncbi.nlm.nih.gov/21227905
https://pubmed.ncbi.nlm.nih.gov/21227905