Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Daniel E. Zak"'
Autor:
Olmo Sonzogni, Daniel E. Zak, Maria Stella Sasso, Rochelle Lear, Alice Muntzer, Manuela Zonca, Katy West, Brian R. Champion, James B. Rottman
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Although chimeric antigen receptor (CAR) T cells have emerged as highly effective treatments for patients with hematologic malignancies, similar efficacy has not been achieved in the context of solid tumors. There are several reasons for this dispari
Externí odkaz:
https://doaj.org/article/fc074a31364141db8230cf60b8ebcac2
Autor:
Stuart Meier, James A. Seddon, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Stephanus T. Malherbe, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Stefan H. E. Kaufmann, Tom H. M. Ottenhoff, Thomas J. Scriba, Sara Suliman, Jayne S. Sutherland, Jill Winter, Helena Kuivaniemi, Gerhard Walzl, Gerard Tromp
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB) and remains one of the leading causes of mortality due to an infectious pathogen. Host immune responses have been implicated in driving the progression from infection to severe lung disease.
Externí odkaz:
https://doaj.org/article/53dc7621c5e8448eb9b94fc1116eace8
Autor:
January Weiner, Jeroen Maertzdorf, Jayne S. Sutherland, Fergal J. Duffy, Ethan Thompson, Sara Suliman, Gayle McEwen, Bonnie Thiel, Shreemanta K. Parida, Joanna Zyla, Willem A. Hanekom, Robert P. Mohney, W. Henry Boom, Harriet Mayanja-Kizza, Rawleigh Howe, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Daniel E. Zak, Gerhard Walzl, Stefan H. E. Kaufmann, The GC6-74 consortium
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The tuberculosis pandemic requires new methods for diagnosing and containing infections prior to active disease. Here, the authors performed a multi-site observational study within sub-Saharan Africa and present serum and plasma metabolic signatures
Externí odkaz:
https://doaj.org/article/05ed44b4c9294316afa2b3d18f1beb1a
Autor:
Trust Odia, Stephanus T. Malherbe, Stuart Meier, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Helena Kuivaniemi, Katharina Ronacher, Jill Winter, Gerhard Walzl, Gerard Tromp, the Catalysis TB-Biomarker Consortium, André G. Loxton, Annare Ellman, Bronwyn Smith, Caroline G. G. Beltran, Clifton E. Barry, David Alland, Friedrich Thienemann, James M. Warwick, Kim Stanley, Ilse Kant, Lani Thiart, Lance A. Lucas, Laura E. Via, Lori E. Dodd, Magdalena Kriel, Nelita Plessis Du, Patrick Dupont, Ray Y. Chen, Robert J. Wilkinson, Shubhada Shenai, Stephanie Griffith-Richards
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue destruction. Here we used within-subject peripheral blood gene expression over time to correlate with the within-subject lung metabolic activity, as measured by
Externí odkaz:
https://doaj.org/article/70919f9b260c42568cd12c831dc3bbde
Autor:
Ying Du, Ethan G. Thompson, Julius Muller, Joseph Valvo, Jackie Braun, Smitha Shankar, Robert A. van den Berg, Erik Jongert, Drew Dover, Jerald Sadoff, Jenny Hendriks, Malcolm J. Gardner, W. Ripley Ballou, Jason A. Regules, Robbert van der Most, Alan Aderem, Christian F. Ockenhouse, Adrian V. Hill, Ulrike Wille-Reece, Daniel E. Zak
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The RTS,S/AS01 vaccine provides partial protection against Plasmodium falciparum infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associ
Externí odkaz:
https://doaj.org/article/7307d7b8880a4c2faaa0b56834a30238
Autor:
Fatoumatta Darboe, Stanley Kimbung Mbandi, Kogieleum Naidoo, Nonhlanhla Yende-Zuma, Lara Lewis, Ethan G. Thompson, Fergal J. Duffy, Michelle Fisher, Elizabeth Filander, Michele van Rooyen, Nicole Bilek, Simbarashe Mabwe, Lyle R. McKinnon, Novel Chegou, Andre Loxton, Gerhard Walzl, Gerard Tromp, Nesri Padayatchi, Dhineshree Govender, Mark Hatherill, Salim Abdool Karim, Daniel E. Zak, Adam Penn-Nicholson, Thomas J. Scriba, The SATVI Clinical Immunology Team
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
HIV-infected individuals are at high risk of tuberculosis disease and those with prior tuberculosis episodes are at even higher risk of disease recurrence. A non-sputum biomarker that identifies individuals at highest tuberculosis risk would allow ta
Externí odkaz:
https://doaj.org/article/5b5f1e53559f4c2fb7b43257840ff756
Autor:
Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Stefan H. E. Kaufmann, Daniel E. Zak, The GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. F. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. G. Loxton, N. N. Chegou, S. Suliman, T. Scriba, M. Fisher, H. Mahomed, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong, C. W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. M. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
There remains a pressing need for biomarkers that can predict who will progress to active tuberculosis (TB) after exposure to Mycobacterium tuberculosis (MTB) bacterium. By analyzing cohorts of household contacts of TB index cases (HHCs) and a string
Externí odkaz:
https://doaj.org/article/1eba36dc045c44aa95b786e37918a63e
Autor:
Daniel F. Hoft, Azra Blazevic, Asmir Selimovic, Aldin Turan, Jan Tennant, Getahun Abate, John Fulkerson, Daniel E. Zak, Robert Walker, Bruce McClain, Jerry Sadoff, Judy Scott, Barbara Shepherd, Jasur Ishmukhamedov, David A. Hokey, Veerabadran Dheenadhayalan, Smitha Shankar, Lynn Amon, Garnet Navarro, Rebecca Podyminogin, Alan Aderem, Lew Barker, Michael Brennan, Robert S. Wallis, Anne A. Gershon, Michael D. Gershon, Sharon Steinberg
Publikováno v:
EBioMedicine, Vol 7, Iss C, Pp 278-286 (2016)
Background: We report a first-in-human trial evaluating safety and immunogenicity of a recombinant BCG, AERAS-422, over-expressing TB antigens Ag85A, Ag85B, and Rv3407 and expressing mutant perfringolysin. Methods: This was a randomized, double-blind
Externí odkaz:
https://doaj.org/article/247fad6c17484ca8917acc90c57cd726
Autor:
Fergal J. Duffy, Ethan Thompson, Katrina Downing, Sara Suliman, Harriet Mayanja-Kizza, W. Henry Boom, Bonnie Thiel, January Weiner III, Stefan H. E. Kaufmann, Drew Dover, David L. Tabb, Hazel M. Dockrell, Tom H. M. Ottenhoff, Gerard Tromp, Thomas J. Scriba, Daniel E. Zak, Gerhard Walzl, the GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. Loxton, N. N. Chegou, S. Suliman, T. Scriba, H. Mahomed, M. Erasmus, O. Xasa, A. Veldsman, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong C, W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Biomarkers that predict who among recently Mycobacterium tuberculosis (MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and circulating miRNAs (c-miR
Externí odkaz:
https://doaj.org/article/a450c97d56b9481c89cbc4507d35a4ef
Autor:
Stephen A. Ramsey, Sandy L. Klemm, Daniel E. Zak, Kathleen A. Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S. Gold, Carrie D. Johnson, Vladimir Litvak, Garnet Navarro, Jared C. Roach, Carrie M. Rosenberger, Alistair G. Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 4 (2008)
Externí odkaz:
https://doaj.org/article/5a1cd33085a04451a6d86bb5efaa2360