Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel E. Rothschild"'
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1517-1527 (2017)
Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus driven by T cell and eosinophil responses to dietary allergens, resulting in chronic mucosal inflammation. Few spontaneous animal models of esophageal eosinophilia exist, with mos
Externí odkaz:
https://doaj.org/article/464073cd57574979b6283e52ca21b688
Autor:
Daniel E. Rothschild, Yao Zhang, Na Diao, Christina K. Lee, Keqiang Chen, Clayton C. Caswell, Daniel J. Slade, Richard F. Helm, Tanya LeRoith, Liwu Li, Irving C. Allen
Publikováno v:
EBioMedicine, Vol 15, Iss C, Pp 36-47 (2017)
Aberrant inflammation is a hallmark of inflammatory bowel disease (IBD) and colorectal cancer. IRAK-M is a critical negative regulator of TLR signaling and overzealous inflammation. Here we utilize data from human studies and Irak-m−/− mice to el
Externí odkaz:
https://doaj.org/article/1d4998e8db6b4e1c84ee8dca4b4b51fc
Autor:
Renata L.S. Goncalves, Daniel E. Rothschild, Casey L. Quinlan, Gary K. Scott, Christopher C. Benz, Martin D. Brand
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 901-909 (2014)
p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis. However, there are
Externí odkaz:
https://doaj.org/article/19da9bd8d6454addab9675cf8d357e39
Autor:
Thomas Brickler, Kisha Gresham, Armand Meza, Sheryl Coutermarsh-Ott, Tere M. Williams, Daniel E. Rothschild, Irving C. Allen, Michelle H. Theus
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
Traumatic brain injury (TBI) elicits the immediate production of proinflammatory cytokines which participate in regulating the immune response. While the mechanisms of adaptive immunity in secondary injury are well characterized, the role of the inna
Externí odkaz:
https://doaj.org/article/a7203925f3fe4188aa370cf5de16cad7
Autor:
Alysha Simmons, Daniel E. Rothschild, Rachel A. Leeth, Dylan K. McDaniel, Tere M. Williams, Sheryl Coutermarsh-Ott, Thomas E. Cecere, Irving C. Allen, Bettina Heid
Publikováno v:
The Journal of Immunology. 194:3369-3380
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a diverse family of pattern recognition receptors that are essential mediators of inflammation and host defense in the gastrointestinal system. Recent studies have identified a subg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98116de698f899790ffeb5244cd52319
https://doi.org/10.4049/jimmunol.1402098
https://doi.org/10.4049/jimmunol.1402098
Autor:
Irving C. Allen, Daniel E. Rothschild, Sheryl Coutermarsh-Ott, Bettina Heid, Alysha Simmons, Kye H. Kable, Rachel A. Leeth, Dylan K. McDaniel, Tere M. Williams
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G139-G150
Nucleotide-binding domain and leucine-rich repeat containing protein inflammasome formation plays an essential role in modulating immune system homeostasis in the gut. Recently, a caspase-11 noncanonical inflammasome has been characterized and appear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7dd1331a0cd1481a389debcd2ec4e6
https://doi.org/10.1152/ajpgi.00234.2014
https://doi.org/10.1152/ajpgi.00234.2014
Autor:
Gary K. Scott, M Muthurajah, Katya Frazier, David Chu, Ravneet Kaur, Daniel E. Rothschild, Christopher C. Benz, Ben Ho Park
Publikováno v:
Cancer Research. 76:PD2-04
Background: Certain ERα phosphorylation (p) sites are essential for ERα transcriptional activity; and with development of ERα p-specific antibodies, some of these sites predict endocrine responsiveness. Unlike other ERα p-sites, pS294 has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee5430f5508e28ad713cc3b4c774ddd3
https://doi.org/10.1158/1538-7445.sabcs15-pd2-04
https://doi.org/10.1158/1538-7445.sabcs15-pd2-04
Publikováno v:
Journal of leukocyte biology.
Immune system activation is essential to thwart the invasion of pathogens and respond appropriately to tissue damage. However, uncontrolled inflammation can result in extensive collateral damage underlying a diverse range of auto-inflammatory, hyper-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fdf25b20fee6b87bef4637a3961177
https://pubmed.ncbi.nlm.nih.gov/29389019
https://pubmed.ncbi.nlm.nih.gov/29389019
Autor:
Casey L. Quinlan, Daniel E. Rothschild, Gary K. Scott, Martin D. Brand, Renata L.S. Goncalves, Christopher C. Benz
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 901-909 (2014)
Redox Biology
Redox Biology
p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis. However, there are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a214b3b283d79b5aceac2fcf5be8a4df
Autor:
Irving C. Allen, Ami Jo, Judy S. Riffle, Daniel E. Rothschild, Sheryl Coutermarsh-Ott, Michael D. Powell, Richey M. Davis, Rui Zhang, Timothy Edward Long, Dylan K. McDaniel, Veronica M. Ringel-Scaia, Kenneth J. Oestreich
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 13(3)
Nanoparticle based drug delivery platforms have the potential to transform disease treatment paradigms and therapeutic strategies, especially in the context of pulmonary medicine. Once administered, nanoparticles disperse throughout the lung and many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da0f2e81c98f5fdd89c1728756508af
https://pubmed.ncbi.nlm.nih.gov/28040495
https://pubmed.ncbi.nlm.nih.gov/28040495