Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daniel E. Petrillo"'
Autor:
Christie Michael, James J. Reif, Dale R. Mowrey, Karen L. Milkiewicz, Roger P. Bakale, Mark A. Olsen, Vikram C. Purohit, Shawn P. Allwein, Christopher J. Neville, Gregory J. Gilmartin, Daniel E. Petrillo
Publikováno v:
Organic Process Research & Development. 21:740-747
The development of a scalable route to TEV-37440, a dual inhibitor of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK), is presented. The medicinal chemistry route used to support this target through nomination is reviewed, along with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec21e0c7f9669dcf7d81e1a7566b1156
https://doi.org/10.1021/acs.oprd.7b00070
https://doi.org/10.1021/acs.oprd.7b00070
Publikováno v:
Organic Process Research & Development. 16:1861-1865
A cost-effective one-pot synthesis of Fmoc-O-benzylphospho-l-serine, an amino acid commonly used in the synthesis of phosphorylated peptides, has been developed. Two methods for executing this synthesis are described, and both have been scaled to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::177273f36058c730df872197d022d1ac
https://doi.org/10.1021/op300233g
https://doi.org/10.1021/op300233g
Publikováno v:
Organic Letters. 14:1206-1209
Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00935fd5414acce5bb9fd2a65eaeabea
https://doi.org/10.1021/ol203332j
https://doi.org/10.1021/ol203332j
Autor:
Shawn P. Allwein, Dale R. Mowrey, Renee C. Roemmele, Diane E. Gingrich, Roger P. Bakale, Daniel E. Petrillo, James J. Haley, James J. Reif
Publikováno v:
Organic Process Research & Development. 16:148-155
Evolution of the process strategies to prepare CEP-28122, an anaplastic lymphoma kinase (ALK) inhibitor, is presented. The initial medicinal chemistry route, used for the preparation of key supplie...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87652bb6c8d2133a00f6705e1d407d35
https://doi.org/10.1021/op200313v
https://doi.org/10.1021/op200313v
Autor:
Daniel E. Petrillo, Gary A. Molander
Publikováno v:
Organic Letters. 10:1795-1798
Ketone-, ester-, and amide-containing potassium trifluoroboratohomoenolates were prepared in good to excellent yields from the corresponding unsaturated carbonyl compounds. They were shown to be effective coupling partners in the Suzuki-Miyaura react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613515a2d400c07bc592a5af0b858631
https://doi.org/10.1021/ol800357c
https://doi.org/10.1021/ol800357c
Publikováno v:
Synlett. :1763-1766
The Suzuki-Miyaura cross-coupling of potassium aryl-and heteroaryltrifluoroborates with aryl- and heteroaryl triflates is reported. The catalyst system provides good to excellent yields using sterically hindered and electronically diverse coupling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6be3884cd1f746f0d7481aa9bc996a
https://doi.org/10.1055/s-2005-871544
https://doi.org/10.1055/s-2005-871544
Publikováno v:
ChemInform. 43
A simple and inexpensive one-pot procedure for the preparation of various protected phosphoamino acids is developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf80b18d7e5a63c3cd27dc668c091f4
https://doi.org/10.1002/chin.201226206
https://doi.org/10.1002/chin.201226206
Autor:
Daniel E. Petrillo, Gary A. Molander
Publikováno v:
Organic Syntheses
Trimethyl borate Phenethylmagnesium chloride Potassium hydrogen fluoride Potassium 2-phenetrifluoroborate 4-Bromoacetophenone Triphenylphosphine Palladium acetate Keywords: acetylphenyl phenylethane; bromoacetophenone; potassium organotrifluoroborate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cba39bddac6a404a0f75d644f549bb0
https://doi.org/10.1002/0471264229.os084.31
https://doi.org/10.1002/0471264229.os084.31
Autor:
Daniel E. Petrillo, Gary A. Molander
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
[153766-81-5] C6H5BF3K [MW 184.00] InChI = 1S/C6H5BF3.K/c8-7(9,10)6-4-2-1-3-5-6;/h1-5H;/q-1;+1 InChIKey = DVAFPKUGAUFBTJ-UHFFFAOYSA-N (air stable, nucleophilic coupling partner in palladium-catalyzed cross-coupling;3-7 rhodium-catalyzed 1,2- and 1,4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c798962ff66789f21f78aaecb9193dd
https://doi.org/10.1002/047084289x.rn00630
https://doi.org/10.1002/047084289x.rn00630