Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Daniel E. Patterson"'
Publikováno v:
Administrative Theory & Praxis. 41:186-188
Reviewed by Daniel E. Patterson and Sharon MastracciUniversity of Utah“You don’t have to choose between being scientific and being compassionate.” (Sapolsky, 2017, p. 675)In Descartes’ Error: Emoti...
Autor:
B. Liu, Vassil I. Elitzin, J. Powers, Daniel E. Patterson, Roman Davis, Elie Amine Tabet, Chong Pek Yoke, Matthew Salmons, M. Toczko, Mark A. Hatcher, Kae M. Bullock, M. Jackson
Publikováno v:
Topics in Catalysis. 55:446-452
Transition metal catalysis by Cu (CF3Cu), Ir (C–H activation), and Ru (ring-closing metathesis) were applied to prepare a complicated tetra substituted pyrazolopyridine drug candidate at GlaxoSmithKline. CuI/FSO2CF2CO2Me was utilized to install a C
Autor:
Alan Millar, Claire Crawford, Sandeep B. Kedia, Bobby N. Glover, Jeremiah D. Powers, Christopher J. Nichols, Malcolm B. Berry, Mark B. Mitchell, Michael S. McClure, Brian C. Crump, Daniel E. Patterson, Darren Caine
Publikováno v:
European Journal of Organic Chemistry. 2012:3561-3565
A highly selective method for the alkoxycarboxylation and acylation of primary alcohols of pyranose derivatives is described. The reaction is high yielding and proceeds under mild conditions with 0.15–1 mol-% Sc(OTf)3 used in combination with anhyd
Autor:
Michael P LeBlanc, Jeremiah D. Powers, Erwin Irdam, Martin H. Osterhout, Tyler Sharkey, Daniel E. Patterson, Emily Boehler
Publikováno v:
Organic Process Research & Development. 13:900-906
A large-scale synthesis of denagliptin tosylate has been developed. The efficiency of the synthesis has been improved from the initially scaled route by changing the order of steps (performing a dehydration at a late stage). The key step of the synth
Autor:
Roman Davis, Andrew D. Brown, Matthew J. Sharp, Bing Liu, Bobby N. Glover, Russ N. Fitzgerald, Lynda A. Jones, Kim A. Harvey, Daniel E. Patterson
Publikováno v:
Organic Process Research & Development. 13:297-302
Three efficient syntheses of sodelglitazar (1) have been developed. In particular, the third synthesis avoids the use of zinc and eliminates the resulting heavy metal waste stream as well as the potential genotoxic methanesulfonate in the two earlier
Autor:
Kristjan S. Gudmundsson, Mark D. Trone, Boggs Sharon Davis, Richard T. Matsuoka, Shiping Xie,‡ and, Xiaoming Zhou, Vicente Samano, Daniel E. Patterson, Lynda A. Jones, Alan Millar, Jeremy D. Cobb
Publikováno v:
Organic Process Research & Development. 11:539-545
An efficient asymmetric synthesis of N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide 1, a potential treatment for human papillomavirus infections, is described. The key step in the synthesis of this molecule is an asymmetr
Autor:
Martin H. Osterhout, and Christopher G. Henry, Shiping Xie, Thomas D. Roper, Lynda A. Jones, Daniel E. Patterson
Publikováno v:
Organic Process Research & Development. 11:624-627
4-Fluoro-β-(4-fluorophenyl)-l-phenylalanine 1 was synthesized by the asymmetric phase-transfer catalyzed alkylation of tert-butyl glycinate-benzophenone Schiff base using the cinchona alkaloid derived catalyst 6. Upon scaling, it was observed that t
Publikováno v:
Chemistry - A European Journal. 7:3768-3775
Kinetic resolutions and kinetic asymmetric transformations (KAT) as well as dynamic kinetic resolutions and dynamic kinetic asymmetric transformations (DYKAT) are important synthetic protocols. The feasibility of KAT and DYKAT processes for asymmetri
Autor:
Barry M. Trost, Daniel E. Patterson
Publikováno v:
Chemistry - A European Journal. 5:3279-3284
The four contiguous stereocenters of (−)-swainsonine were efficiently set in a 15-step synthesis with a 15 % overall yield and >99% ee. In order to differeniate the double bond in the key building block oxazolidin-2-one 2, a synthetic equivalent of
Autor:
Darren Caine, Sandeep B. Kedia, Mark B. Mitchell, Bobby N. Glover, Christopher J. Nichols, Jeremiah D. Powers, Brian C. Crump, Daniel E. Patterson, Malcolm B. Berry, Michael S. McClure, Alan Millar, Claire Crawford
Publikováno v:
European Journal of Organic Chemistry. 2012