Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniel E. Newburger"'
Autor:
Z Weng, Robert B. West, Daniel E. Newburger, X Guo, Megan L. Troxell, Dorna Kashef-Haghighi, Serafim Batzoglou, Shirley Zhu, Raheleh Salari, Arend Sidow, Sushama Varma, Alayne L. Brunner
Publikováno v:
Cancer Research. 72:PD05-09
Cancer evolution involves cycles of genomic damage, epigenetic deregulation, and increased cellular proliferation that eventually culminate in the carcinoma phenotype. Early breast neoplasias include usual ductal hyperplasia, columnar cell lesions, a
Autor:
Hanlee P. Ji, Susan M. Grimes, Serafim Batzoglou, Daniel E. Newburger, Ronald W. Davis, Georges Natsoulis, John Bell
Publikováno v:
Nucleic Acids Research
Recent exponential growth in the throughput of next-generation DNA sequencing platforms has dramatically spurred the use of accessible and scalable targeted resequencing approaches. This includes candidate region diagnostic resequencing and novel var
Autor:
Michael F. Berger, Marcin Pacek, Zachary A. Smith, Federico De Masi, Cong Zhu, Joshua LaBaer, Anthony A. Philippakis, Yanhui Hu, Rachel Patton McCord, T. V. S. Murthy, Daniel E. Newburger, Mathangi Radhakrishnan, Andreas Rolfs, Kelsey J. R. P. Byers, Zhenwei Shi, Katrina Saulrieta, Martha L. Bulyk, Mita V. Shah
Publikováno v:
Genome Research
Transcription factors (TFs) regulate the expression of genes through sequence-specific interactions with DNA-binding sites. However, despite recent progress in identifying in vivo TF binding sites by microarray readout of chromatin immunoprecipitatio
Autor:
Shaheynoor Talukder, Savina Jaeger, Lourdes Peña-Castillo, Quaid Morris, Gwenael Badis, Sanie Mnaimneh, Olga B. Botvinnik, Esther T. Chan, Anthony A. Philippakis, Andrew R. Gehrke, Trevis M. Alleyne, Martha L. Bulyk, Wen Zhang, Daniel E. Newburger, Timothy P. Hughes, Michael F. Berger, Faiqua Khalid
Publikováno v:
Cell
Cell, Elsevier, 2008, 133 (7), pp.1266-1276. ⟨10.1016/j.cell.2008.05.024⟩
Cell, Elsevier, 2008, 133 (7), pp.1266-1276. ⟨10.1016/j.cell.2008.05.024⟩
International audience; Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences of the
Autor:
Serafim Batzoglou, Arend Sidow, Shirley Zhu, Robert B. West, Daniel E. Newburger, Dorna Kashef-Haghighi, Noah Spies, Ziming Weng
Publikováno v:
Genome Medicine
Background All cells in an individual are related to one another by a bifurcating lineage tree, in which each node is an ancestral cell that divided into two, each branch connects two nodes, and the root is the zygote. When a somatic mutation occurs
Autor:
Alex Bishara, Dorna Kashef-Haghighi, Arend Sidow, Ziming Weng, Yuling Liu, Daniel E. Newburger, Robert B. West, Serafim Batzoglou
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783319167053
RECOMB
RECOMB
Although an increasing amount of human genetic variation is being identified and recorded, determining variants within repeated sequences of the human genome remains a challenge. Most population and genome-wide association studies have therefore been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd97df2f6e5fc6d3d03fbebd52cfa43a
https://doi.org/10.1007/978-3-319-16706-0_5
https://doi.org/10.1007/978-3-319-16706-0_5
Autor:
Charles Midgett, Kinga K. Tomczak, Ana Morales, Susan T. Iannaccone, Melisa A. Poulos, Pankaj B. Agrawal, Alan H. Beggs, Monique M. Ryan, Thomas O. Crawford, Nigel G. Laing, Daniel E. Newburger, Corinne D. Strickland
Publikováno v:
Annals of Neurology. 56:86-96
Nemaline myopathy (NM) is the most common of several congenital myopathies that present with skeletal muscle weakness and hypotonia. It is clinically heterogeneous and the diagnosis is confirmed by identification of nemaline bodies in affected muscle
Autor:
Dorna Kashef-Haghighi, Raheleh Salari, Alayne L. Brunner, Shirley Zhu, Xiangqian Guo, Daniel E. Newburger, Robert T. Sweeney, Arend Sidow, Sushama Varma, Megan L. Troxell, Robert B. West, Serafim Batzoglou, Ziming Weng
Cancer evolution involves cycles of genomic damage, epigenetic deregulation, and increased cellular proliferation that eventually culminate in the carcinoma phenotype. Early neoplasias, which are often found concurrently with carcinomas and are histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d01811f87c96c7756f639321d4fd5c8
https://europepmc.org/articles/PMC3698503/
https://europepmc.org/articles/PMC3698503/
Autor:
Arend Sidow, Syed Shayon Saleh, David A. Khavari, Serafim Batzoglou, Robert B. West, Daniel E. Newburger, Dorna Kashef-Haghighi, Raheleh Salari
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783642371943
RECOMB
RECOMB
Next-generation sequencing technologies provide a powerful tool for studying genome evolution during progression of advanced diseases such as cancer. Although many recent studies have employed new sequencing technologies to detect mutations across mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d4d7e97b520492e301209ac02c4193
https://doi.org/10.1007/978-3-642-37195-0_21
https://doi.org/10.1007/978-3-642-37195-0_21
Autor:
John Bell, Nan Zhang, Georges Natsoulis, Itai Kela, Omkar Muralidharan, Hua Xu, Daniel E. Newburger, Hanlee P. Ji
Publikováno v:
Nucleic Acids Research
Highly multiplex DNA sequencers have greatly expanded our ability to survey human genomes for previously unknown single nucleotide polymorphisms (SNPs). However, sequencing and mapping errors, though rare, contribute substantially to the number of fa