Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Daniel E. Larcombe"'
Autor:
Qinxi Ma, Arnab Pradhan, Ian Leaves, Emer Hickey, Elena Roselletti, Ivy Dambuza, Daniel E. Larcombe, Leandro Jose de Assis, Duncan Wilson, Lars P. Erwig, Mihai G. Netea, Delma S. Childers, Gordon D. Brown, Neil A.R. Gow, Alistair J.P. Brown
Publikováno v:
The Cell Surface, Vol 11, Iss , Pp 100128- (2024)
Host recognition of the pathogen-associated molecular pattern (PAMP), β-1,3-glucan, plays a major role in antifungal immunity. β-1,3-glucan is an essential component of the inner cell wall of the opportunistic pathogen Candida albicans. Most β-1,3
Externí odkaz:
https://doaj.org/article/246a9682c09641f7a0a0fda1cc487324
Autor:
Gabriela M. Avelar, Arnab Pradhan, Qinxi Ma, Emer Hickey, Ian Leaves, Corin Liddle, Alejandra V. Rodriguez Rondon, Ann-Kristin Kaune, Sophie Shaw, Corinne Maufrais, Natacha Sertour, Judith M. Bain, Daniel E. Larcombe, Leandro J. de Assis, Mihai G. Netea, Carol A. Munro, Delma S. Childers, Lars P. Erwig, Gordon D. Brown, Neil A. R. Gow, Marie-Elisabeth Bougnoux, Christophe d'Enfert, Alistair J. P. Brown
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Microbial species capable of co-existing with healthy individuals, such as the commensal fungus Candida albicans, exploit multifarious strategies to evade our immune defenses. These strategies include the masking of immunoinflammatory pathog
Externí odkaz:
https://doaj.org/article/a315d65d8db7474e9c59617b6af6132d
Autor:
Leandro José de Assis, Judith M. Bain, Corin Liddle, Ian Leaves, Christian Hacker, Roberta Peres da Silva, Raif Yuecel, Attila Bebes, David Stead, Delma S. Childers, Arnab Pradhan, Kevin Mackenzie, Katherine Lagree, Daniel E. Larcombe, Qinxi Ma, Gabriela Mol Avelar, Mihai G. Netea, Lars P. Erwig, Aaron P. Mitchell, Gordon D. Brown, Neil A. R. Gow, Alistair J. P. Brown
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract without causing pathology. However, this fungus is also a common cause of mucosal and systemic infections when antifungal immune defenses become compro
Externí odkaz:
https://doaj.org/article/7eee21d07077458d862a678b6efa049c
Autor:
Gabriela M. Avelar, Ivy M. Dambuza, Liviana Ricci, Raif Yuecel, Kevin Mackenzie, Delma S. Childers, Judith M. Bain, Arnab Pradhan, Daniel E. Larcombe, Mihai G. Netea, Lars P. Erwig, Gordon D. Brown, Sylvia H. Duncan, Neil A.R. Gow, Alan W. Walker, Alistair J.P. Brown
Publikováno v:
The Cell Surface, Vol 8, Iss , Pp 100084- (2022)
The immunogenicity of Candida albicans cells is influenced by changes in the exposure of microbe-associated molecular patterns (MAMPs) on the fungal cell surface. Previously, the degree of exposure on the C. albicans cell surface of the immunoinflamm
Externí odkaz:
https://doaj.org/article/369d68d889004bc9b1d341433c89942b
Autor:
Arnab Pradhan, Gabriela M. Avelar, Judith M. Bain, Delma Childers, Chloe Pelletier, Daniel E. Larcombe, Elena Shekhova, Mihai G. Netea, Gordon D. Brown, Lars Erwig, Neil A. R. Gow, Alistair J. P. Brown
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The authors show that the fungal pathogen Candida albicans exploits diverse host-associated signals, including specific nutrients and stresses, to promote immune evasion by masking cell wall β-glucan, a major pathogen-associated molecular pattern.
Externí odkaz:
https://doaj.org/article/bd3459245a7f49d29f8307da698409ae
Autor:
Delma S. Childers, Gabriela Mol Avelar, Judith M. Bain, Arnab Pradhan, Daniel E. Larcombe, Mihai G. Netea, Lars P. Erwig, Neil A. R. Gow, Alistair J. P. Brown
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The cell wall provides a major physical interface between fungal pathogens and their mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival. Fungus-specific cell wall moieties, such as β-1,3-glucan, ar
Externí odkaz:
https://doaj.org/article/4da9c9b4bb334467bcbb87a32cd2e4e6
Autor:
Arnab Pradhan, Gabriela M. Avelar, Judith M. Bain, Delma S. Childers, Daniel E. Larcombe, Mihai G. Netea, Elena Shekhova, Carol A. Munro, Gordon D. Brown, Lars P. Erwig, Neil A. R. Gow, Alistair J. P. Brown
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Organisms must adapt to changes in oxygen tension if they are to exploit the energetic benefits of reducing oxygen while minimizing the potentially damaging effects of oxidation. Consequently, organisms in all eukaryotic kingdoms display rob
Externí odkaz:
https://doaj.org/article/7246d978081d4c2eaaefcf2803e7a1d6
Publikováno v:
Fungal Biology
The model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, display Core Environmental Responses (CERs) that include the induction of a core set of stress genes in response to diverse environmental stresses. CERs underlie the phenomenon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f6794d9c711bce5d8488a7a1a7d52d
http://europepmc.org/articles/PMC7232023
http://europepmc.org/articles/PMC7232023
Autor:
Delma S. Childers, Arnab Pradhan, Kevin R. MacKenzie, Daniel E. Larcombe, M Fernanda Alonso, Johanna Louw, Catriona A Walls, Gordon D. Brown, Alistair J. P. Brown, Neil A. R. Gow, Gabriela Mol Avelar, Leanne E. Lewis, Mihai G. Netea, Lars Erwig, Judith M. Bain
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance Macrophages protect against microbial infection, in part by engulfing and killing invading microbes. Fungal pathogens such as Candida albicans are known to evade phagocytic killing by forming hyphae that are physically challenging to eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3037a1b3194ee0d012b6b32c2da8be0a
https://pubmed.ncbi.nlm.nih.gov/33876755
https://pubmed.ncbi.nlm.nih.gov/33876755
Autor:
Qinxi Ma, Daniel E. Larcombe, Olga A. Nev, Leandro José de Assis, Arnab Pradhan, Alejandra V. Rodriguez Rondon, Alistair J. P. Brown, Ian Leaves
In certain niches, microbes encounter environmental challenges that are temporally linked. In such cases, microbial fitness is enhanced by the evolution of anticipatory responses where the initial challenge simultaneously activates pre-emptive protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef98e6f7155542458b8dbf0004335f20
https://mural.maynoothuniversity.ie/17258/
https://mural.maynoothuniversity.ie/17258/
