Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel E. Beck"'
Autor:
Ramya Visvanathan, Tadanobu Utsuki, Daniel E. Beck, Emma Lendy, Kuai-lin Sun, Yinghui Liu, Kirk W. Hering, Andrew Mesecar, Zhong-Yin Zhang, Karson S. Putt
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 170-179 (2023)
A rare coding variant in PLCγ2 (P522R) expressed in microglia induces a mild activation of enzymatic activity when compared to wild-type. This mutation is reported to be protective against the cognitive decline associated with late-onset Alzheimer's
Externí odkaz:
https://doaj.org/article/2d760758ae3a4d61921580a59ddd5056
Autor:
Cynthia D. Jesudason, Emily R. Mason, Shaoyou Chu, Adrian L. Oblak, June Javens‐Wolfe, Mustapha Moussaif, Greg Durst, Philip Hipskind, Daniel E. Beck, Jiajun Dong, Ovini Amarasinghe, Zhong‐Yin Zhang, Adam K. Hamdani, Kratika Singhal, Andrew D. Mesecar, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Disha M. Soni, Murugesh Kandasamy, Andrea R. Masters, Sara K Quinney, Suzanne Doolen, Hasi Huhe, Stacey J. Sukoff Rizzo, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate‐5‐phosphatase (INPP5D), which encodes Src homology 2 (SH2) domain–containing inositol polyphosphat
Externí odkaz:
https://doaj.org/article/4d6f6a10135b4cdbb5e5fc4dd51947a7
Autor:
Timothy I Richardson, Cynthia D Jesudason, Karen L Lobb, Gregory L Durst, Brent Clayton, Steven M Massey, Daniel E Beck, Zhong‐Yin Zhang, Jiajun Dong, Jianping Lin, Jinmin Miao, Karson S Putt, Andrew D Mesecar, Adam K Hamdani, Emma K Lendy, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Shaoyou Chu, Emily R Mason, Adrian L Oblak, Disha Soni, Sara K Quinney, Larissa L Silva, Murugesh Kandasamy, Andrea R Masters, Stacey J Sukoff Rizzo, Suzanne Doolen, Kun Huang, Jie Zhang, Bruce T Lamb, Alan D Palkowitz
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Mark Cushman, Monica Abdelmalak, Gabrielle S. Tender, Christophe Marchand, P. V. Narasimha Reddy, Yves Pommier, Keli Agama, Daniel E. Beck, Sophia Lopez, Wei Lv
Publikováno v:
Journal of Medicinal Chemistry. 59:3840-3853
Several indenoisoquinolines have shown promise as anticancer agents in clinical trials. Incorporation of a nitrogen atom into the indenoisoquinoline scaffold offers the possibility of favorably modulating ligand-binding site interactions, physicochem
Autor:
William D. Figg, Keli Agama, Mohamed S. A. Elsayed, Junko Murai, Daniel E. Beck, Amy James, Mark Cushman, Cody J. Peer, Yves Pommier, Laetitia Marzi, Simone Difilippantonio
Contrary to other anticancer targets, topoisomerase I (TOP1) is targeted by only one chemical class of FDA-approved drugs: topotecan and irinotecan, the derivatives of the plant alkaloid, camptothecin. The indenoisoquinolines LMP400, LMP744, and LMP7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3336b6564d16a1b95e0e6f26ac56dcb
https://europepmc.org/articles/PMC6072611/
https://europepmc.org/articles/PMC6072611/
Autor:
Christophe Marchand, Yves Pommier, P. V. Narasimha Reddy, Gabrielle S. Tender, Monica Abdelmalak, Keli Agama, Mark Cushman, Elizaveta O’Neill, Wei Lv, Daniel E. Beck
Publikováno v:
J Med Chem
3-Nitroindenoisoquinoline human topoisomerase IB (Top1) poisons have potent antiproliferative effects on cancer cells. The undesirable nitro toxicophore could hypothetically be replaced by other functional groups that would retain the desired biologi
Publikováno v:
Journal of Medicinal Chemistry
Carbohydrate moieties were strategically transported from the indolocarbazole topoisomerase I (Top1) inhibitor class to the indenoisoquinoline system in search of structurally novel and potent Top1 inhibitors. The syntheses and biological evaluation
Autor:
Christophe Marchand, Yves Pommier, Wei Lv, Keli Agama, Mark Cushman, Daniel E. Beck, Caroline B. Plescia, Monica Abdelmalak
Publikováno v:
Bioorganicmedicinal chemistry. 24(7)
Fluorine and chlorine are metabolically stable, but generally less active replacements for a nitro group at the 3-position of indenoisoquinoline topoisomerase IB (Top1) poisons. A number of strategies were employed in the present investigation to enh
Autor:
Bingjie Hu, Martin Conda-Sheridan, Jerry J. White, Trung Xuan Nguyen, P. V. Narasimha Reddy, Eun-Jung Park, Daniel E. Beck, John M. Pezzuto, Richard B. van Breemen, Lian Chen, Mark Cushman
Publikováno v:
Journal of medicinal chemistry. 56(6)
Nuclear receptors, such as the retinoid X receptor (RXR), are proteins that regulate a myriad of cellular processes. Molecules that function as RXR agonists are of special interest for the prevention and control of carcinogenesis. The majority of the
Autor:
Ramya Visvanathan, Tadanobu Utsuki, Daniel E Beck, W Brent Clayton, Emma Lendy, Kuai-Lin Sun, Yinghui Liu, Kirk W Hering, Andrew Mesecar, Zhong-Yin Zhang, Karson S Putt
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299541 (2024)
The activities of the phospholipase C gamma (PLCγ) 1 and 2 enzymes are essential for numerous cellular processes. Unsurprisingly, dysregulation of PLCγ1 or PLCγ2 activity is associated with multiple maladies including immune disorders, cancers, an
Externí odkaz:
https://doaj.org/article/07330adcb09c40d7bd2c75877bb72103