Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Daniel E Stange"'
Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer
Autor:
Therese Seidlitz, Tim Schmäche, Fernando Garcίa, Joon Ho Lee, Nan Qin, Susan Kochall, Juliane Fohgrub, David Pauck, Alexander Rothe, Bon‐Kyoung Koo, Jürgen Weitz, Marc Remke, Javier Muñoz, Daniel E Stange
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 10, Pp 1-16 (2022)
Abstract Gastric cancer ranks the fifth most common and third leading cause of cancer‐related deaths worldwide. Alterations in the RTK/MAPK, WNT, cell adhesion, TP53, TGFβ, NOTCH, and NFκB signaling pathways could be identified as main oncogenic
Externí odkaz:
https://doaj.org/article/f802034c439b4483bafd7d13f0124bf1
Autor:
Tim Schmäche, Juliane Fohgrub, Anna Klimova, Karin Laaber, Stephan Drukewitz, Felix Merboth, Alexander Hennig, Therese Seidlitz, Friederike Herbst, Franziska Baenke, Anne-Marlen Ada, Thomas Groß, Carina Wenzel, Claudia R. Ball, Christian Praetorius, Thomas Schmidt, Barbara Ringelband-Schilling, Ronald Koschny, Albrecht Stenzinger, Ingo Roeder, Dirk Jaeger, Sebastian Zeissig, Thilo Welsch, Daniela Aust, Hanno Glimm, Gunnar Folprecht, Jürgen Weitz, Georg M. Haag, Daniel E. Stange
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-8 (2024)
Abstract Background and aims This study sought to determine the value of patient-derived organoids (PDOs) from esophago-gastric adenocarcinoma (EGC) for response prediction to neoadjuvant chemotherapy (neoCTx). Methods Endoscopic biopsies of patients
Externí odkaz:
https://doaj.org/article/ef3c4b197b1249f6b014c0fc293e9167
Autor:
Alexander Hennig, Laura Wolf, Beatrix Jahnke, Heike Polster, Therese Seidlitz, Kristin Werner, Daniela E. Aust, Jochen Hampe, Marius Distler, Jürgen Weitz, Daniel E. Stange, Thilo Welsch
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Externí odkaz:
https://doaj.org/article/6f0f492668ce4835bf29466e406b3602
Autor:
Alexander Hennig, Laura Wolf, Beatrix Jahnke, Heike Polster, Therese Seidlitz, Kristin Werner, Daniela E. Aust, Jochen Hampe, Marius Distler, Jürgen Weitz, Daniel E. Stange, Thilo Welsch
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Background. Organoid cultures of human pancreatic ductal adenocarcinoma (PDAC) have become a promising tool for tumor subtyping and individualized chemosensitivity testing. PDACs have recently been grouped into different molecular subtypes with clini
Externí odkaz:
https://doaj.org/article/0564d3d4636847e09cc31b2fcf70f1d3
Autor:
Rimante Bandzeviciute, Gerald Steiner, Katja Liedel, Jonas Golde, Edmund Koch, Thilo Welsch, Christoph Kahlert, Daniel E. Stange, Marius Distler, Jürgen Weitz, Justinas Ceponkus, Valdas Sablinskas, Christian Teske
Publikováno v:
Journal of Biomedical Optics. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94bd81f8a5c9ef8a3be46e21ce8acb38
https://doi.org/10.1117/1.jbo.28.4.045004
https://doi.org/10.1117/1.jbo.28.4.045004
Autor:
Frank Buchholz, Jovan Mircetic, Daniel E. Stange, Duran Sürün, Lukas T. Schmitt, Moustafa Abohawya, Catherine P. Cortés Vesga, Martina Augsburg, Alexander Hennig, Olga A. Sidorova, Shady Sayed
KRAS is the most frequently mutated oncogene in human cancer, and its activating mutations represent long-sought therapeutic targets. Programmable nucleases, particularly the CRISPR-Cas9 system, provide an attractive tool for genetically targeting KR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86b344389f77626d4cb30b667924e9db
https://doi.org/10.1158/0008-5472.c.6514029.v1
https://doi.org/10.1158/0008-5472.c.6514029.v1
Autor:
Frank Buchholz, Jovan Mircetic, Daniel E. Stange, Duran Sürün, Lukas T. Schmitt, Moustafa Abohawya, Catherine P. Cortés Vesga, Martina Augsburg, Alexander Hennig, Olga A. Sidorova, Shady Sayed
Supplementary Data from Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184480b0b8b2a28a5b83b544c9b5caf8
https://doi.org/10.1158/0008-5472.22431909
https://doi.org/10.1158/0008-5472.22431909
Autor:
Jan-Hendrik, Egberts, Thilo, Welsch, Felix, Merboth, Sandra, Korn, Christian, Praetorius, Daniel E, Stange, Marius, Distler, Matthias, Biebl, Johann, Pratschke, Felix, Nickel, Beat, Müller-Stich, Daniel, Perez, Jakob R, Izbicki, Thomas, Becker, Jürgen, Weitz
Publikováno v:
Langenbeck's Archives of Surgery. 407:1-11
Abstract Purpose Robotic-assisted minimally invasive esophagectomy (RAMIE) has become one standard approach for the operative treatment of esophageal tumors at specialized centers. Here, we report the results of a prospective multicenter registry for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352b58031e1d99320e75dae08a534cbd
https://doi.org/10.1007/s00423-022-02520-w
https://doi.org/10.1007/s00423-022-02520-w
Autor:
Isaree Teriyapirom, Jihoon Kim, Heetak Lee, Sebastian R. Merker, Amanda Andersson-Rolf, Stephan R. Jahn, Anne-Marlen Ada, Sang-Min Kim, Joo Yeon Lim, Tim Schmäche, Nancy Wetterling, Saskia Stegert, Ji-Yeon Park, Jae-Ho Cheong, Hyunki Kim, Daniel E. Stange, Bon-Kyoung Koo
Recent studies have shed light on the signaling pathways required for gastric tissue maintenance and how aberrations in these key pathways lead to gastric cancer development. Although it has been shown that the WNT pathway is important for gastric ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c64dc1f38c4bc9f365155b3f407f2f5c
https://doi.org/10.1101/2023.02.24.529854
https://doi.org/10.1101/2023.02.24.529854
Autor:
Thilo Welsch, Sebastián García, Marius Distler, Felix Merboth, Jürgen Weitz, Daniel E. Stange, Janusz von Renesse
Publikováno v:
Oncology Research and Treatment. 45:45-53
Introduction: Patients with advanced gastric cancer (AGC) frequently show peritoneal carcinomatosis (PC). PC reduces life expectancy and quality of life. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has been show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1cf152cf7feb9843429e956d02ce60
https://doi.org/10.1159/000520330
https://doi.org/10.1159/000520330