Zobrazeno 1 - 10
of 407
pro vyhledávání: '"Daniel E Otzen"'
Autor:
Juami Hermine Mariama van Gils, Erik van Dijk, Alessia Peduzzo, Alexander Hofmann, Nicola Vettore, Marie P Schützmann, Georg Groth, Halima Mouhib, Daniel E Otzen, Alexander K Buell, Sanne Abeln
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007767 (2020)
Many proteins have the potential to aggregate into amyloid fibrils, protein polymers associated with a wide range of human disorders such as Alzheimer's and Parkinson's disease. The thermodynamic stability of amyloid fibrils, in contrast to that of f
Externí odkaz:
https://doaj.org/article/5afd982d287348af94862bd4c9dee1a0
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Biosurfactants are of growing interest as sustainable alternatives to fossil-fuel-derived chemical surfactants, particularly for the detergent industry. To realize this potential, it is necessary to understand how they affect proteins which they may
Externí odkaz:
https://doaj.org/article/1130528adbbb40c7943ac1b741eda95e
Autor:
Janni Nielsen, Johanne Lauritsen, Jannik N. Pedersen, Jan S. Nowak, Malthe K. Bendtsen, Giulia Kleijwegt, Kaija Lusser, Laia C. Pitarch, Julián V. Moreno, Matthias M. Schneider, Georg Krainer, Louise Goksøyr, Paul Khalifé, Sanne Simone Kaalund, Susana Aznar, Magnus Kjærgaard, Vita Sereikaité, Kristian Strømgaard, Tuomas P. J. Knowles, Morten Agertoug Nielsen, Adam F. Sander, Marina Romero-Ramos, Daniel E. Otzen
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-26 (2024)
Abstract α-Synuclein (α-syn) accumulates as insoluble amyloid but also forms soluble α-syn oligomers (αSOs), thought to be even more cytotoxic than fibrils. To detect and block the unwanted activities of these αSOs, we have raised 30 monoclonal
Externí odkaz:
https://doaj.org/article/e6e9d9eb66fb4db88fab4f91ceef8060
Autor:
Guanghong eZeng, Brian S Vad, Morten S Dueholm, Gunna eChristiansen, Martin eNilsson, Tim eTolker-Nielsen, Per Halkjær Nielsen, Rikke Louise Meyer, Daniel E Otzen
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
The success of Pseudomonas species as opportunistic pathogens derives in great part from their ability to form stable biofilms that offer protection against chemical and mechanical attack. The extracellular matrix of biofilms contains numerous biomol
Externí odkaz:
https://doaj.org/article/a24b49f924aa4b228d62b1dca2797cbf
Autor:
Jens Kvist Madsen, Rasmus ePihl, Anders Hauer Møller, Anne Tranberg Madsen, Daniel E Otzen, Kell Kleiner Andersen
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Biosurfactants (BS) are surface-active molecules produced by microorganisms. Their combination of useful properties and sustainable production make them promising industrial alternatives to petrochemical and oleochemical surfactants. Here we compare
Externí odkaz:
https://doaj.org/article/175fd7914c324c5fb3f3e25f3c5e0399
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10262 (2010)
To obtain insight into the functions of proteins and their specific roles, it is important to establish efficient procedures for exploring the states that encapsulate their conformational space. Global Protein folding State mapping by multivariate NM
Externí odkaz:
https://doaj.org/article/808ac2ba660e45cb8bce49edc17021c7
Autor:
Jan Stanislaw Nowak, Daniel E. Otzen
Publikováno v:
BBA Advances, Vol 5, Iss , Pp 100104- (2024)
Enzymes from psychrophilic (cold-loving) organisms have attracted considerable interest over the past decades for their potential in various low-temperature industrial processes. However, we still lack large-scale commercialization of their activitie
Externí odkaz:
https://doaj.org/article/d1f149f9fd174f839d44a5217386627a
Autor:
Zahra Nayeri, Farhang Aliakbari, Farzaneh Afzali, Soha Parsafar, Ehsan Gharib, Daniel E. Otzen, Dina Morshedi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Despite extensive research, the molecular mechanisms underlying the toxicity of αSN in Parkinson’s disease (PD) pathology are still poorly understood. To address this, we used a microarray dataset to identify genes that are induced and differentia
Externí odkaz:
https://doaj.org/article/7f52cb14bb564d0e85ae8119564a3f87
Autor:
Arun Kumar Somavarapu, Giulia Kleijwegt, Madhu Nagaraj, Parvez Alam, Janni Nielsen, Daniel E. Otzen
Publikováno v:
Somavarapu, A K, Kleijwegt, G, Nagaraj, M, Alam, P, Nielsen, J & Otzen, D E 2023, ' Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions ', Chemical Science, vol. 14, no. 11, pp. 3030-3047 . https://doi.org/10.1039/d2sc05534a
Small soluble oligomers of the protein α-synuclein (αSO) have been linked to disruptions in neuronal homeostasis, contributing to the development of Parkinson's Disease (PD). While this makes αSO an obvious drug target, the development of effectiv
Autor:
Magnus Kjaergaard, Laura Skak Rasmussen, Johan Nygaard Vinther, Kasper Røjkjær Andersen, Ebbe Sloth Andersen, Esben Lorentzen, Søren S. Thirup, Daniel E. Otzen, Ditlev Egeskov Brodersen
Publikováno v:
Kjærgaard, M, Rasmussen, L S, Vinther, J N, Andersen, K R, Andersen, E S, Lorentzen, E, Thirup, S S, Otzen, D & Brodersen, D E 2022, ' A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL ', The Biophysicist, vol. 3, no. 2, pp. 106–114 . https://doi.org/10.35459/tbp.2022.000219
Structural biology describes biological processes at the molecular level and is an integral part of undergraduate study programs in molecular biosciences. Students are often fascinated by the visualizations created by molecular graphics software, whi