Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel E O'Brien"'
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12897 (2010)
Mutations in the PLA2G6 gene have been identified in autosomal recessive neurodegenerative diseases classified as infantile neuroaxonal dystrophy (INAD), neurodegeneration with brain iron accumulation (NBIA), and dystonia-parkinsonism. These clinical
Externí odkaz:
https://doaj.org/article/db7420b899604e6da3ff7bc4000feadf
Autor:
Zixiu, Xiang, Xiaohui, Lv, Xin, Lin, Daniel E, O'Brien, Molly K, Altman, Craig W, Lindsley, Jonathan A, Javitch, Colleen M, Niswender, P Jeffrey, Conn
Publikováno v:
Sci Signal
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. They are thought to function as disulfide-linked homodimers, but studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac13b2be884796b1312bc0e9c0555dda
https://pubmed.ncbi.nlm.nih.gov/33824180
https://pubmed.ncbi.nlm.nih.gov/33824180
Autor:
Colleen M. Niswender, Daniel E. O’Brien, Xiaohui Lv, Molly K. Altman, Zixiu Xiang, Craig W. Lindsley, Xin Lin, Jonathan A. Javitch, P. Jeffrey Conn
Publikováno v:
Science Signaling. 14
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. They are thought to function as disulfide-linked homodimers, but studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0654c27203e610965cf23a871d5699d9
https://doi.org/10.1126/scisignal.abd2319
https://doi.org/10.1126/scisignal.abd2319
Autor:
Colleen M. Niswender, Douglas Shaw, Jonas Bergare, Alan J. Cross, Daniel E. O’Brien, Andrew S. Felts, P. Jeffrey Conn, Steven Wesolowski, Charles S. Elmore, Craig W. Lindsley, Hyekyung P. Cho
Publikováno v:
Molecular Pharmacology. 93:526-540
Allosteric modulation of metabotropic glutamate receptor 2 (mGlu2) has demonstrated efficacy in preclinical rodent models of several brain disorders, leading to industry and academic drug discovery efforts. Although the pharmacology and binding sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64ce8088e13d86301745995d6a424d9c
https://doi.org/10.1124/mol.117.110114
https://doi.org/10.1124/mol.117.110114
Autor:
Samantha E. Yohn, Daniel J. Foster, P. Jeffrey Conn, Daniel E. O’Brien, Muhammad Mahmood, Madigan Lavery, Weimin Peng
Publikováno v:
Journal of Clinical and Translational Science
OBJECTIVES/SPECIFIC AIMS: The objective of this study was to determine if dopamine signaling is altered in a mouse model displaying excessive self-grooming and further elucidate the potential utility of compounds targeting the striatal DA system in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b705d14339a0738284f3341879a5cc
https://doi.org/10.1017/cts.2019.48
https://doi.org/10.1017/cts.2019.48
Autor:
Daniel E, O'Brien, Douglas M, Shaw, Hyekyung P, Cho, Alan J, Cross, Steven S, Wesolowski, Andrew S, Felts, Jonas, Bergare, Charles S, Elmore, Craig W, Lindsley, Colleen M, Niswender, P Jeffrey, Conn
Publikováno v:
Molecular pharmacology. 93(5)
Allosteric modulation of metabotropic glutamate receptor 2 (mGlu(2)) has demonstrated efficacy in preclinical rodent models of several brain disorders, leading to industry and academic drug discovery efforts. Although the pharmacology and binding sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2ddb7f1376ac48e2a1a13cd137d84c6
https://pubmed.ncbi.nlm.nih.gov/29545267
https://pubmed.ncbi.nlm.nih.gov/29545267
Autor:
Sarah L. Trigg, Vijay K. Samineni, Jose G. Grajales-Reyes, Daniel E. O’Brien, Michael R. Bruchas, Bryan A. Copits, Robert W. Gereau, Adrian M. Gomez
Publikováno v:
eNeuro
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa56e0020e1c08f0ace373a124275e55
https://pubmed.ncbi.nlm.nih.gov/28374016
https://pubmed.ncbi.nlm.nih.gov/28374016
Autor:
Jose G. Grajales-Reyes, Robert W. Gereau, Vijay K. Samineni, Daniel E. O’Brien, Bryan A. Copits, Michael R. Bruchas, Adrian M. Gomez, Saranya S. Sundaram
Publikováno v:
The Journal of Pain. 19:S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dca36c03a05ca48b669cb53132125b7
https://doi.org/10.1016/j.jpain.2017.12.030
https://doi.org/10.1016/j.jpain.2017.12.030
Publikováno v:
The Journal of Physiology. 586:835-845
The exercise pressor reflex (EPR) is an important neural mechanism that controls blood pressure and heart rate during static muscle contraction. It has been previously demonstrated that the EPR is exaggerated in cardiomyopathy. Both mechanically (gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ad3d9ec99518d3f1dbd28477526e59
https://doi.org/10.1113/jphysiol.2007.140392
https://doi.org/10.1113/jphysiol.2007.140392
Autor:
Daniel E. O’Brien, P. Jeffrey Conn
Publikováno v:
International Journal of Neuropsychopharmacology
Allosteric modulation of metabotropic glutamate (mGlu) receptors offers a promising pharmacological approach to normalize neural circuit dysfunction associated with various psychiatric and neurological disorders. As mGlu receptor allosteric modulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088ed85f094ff195a8072351119082e5
http://europepmc.org/articles/PMC4886670
http://europepmc.org/articles/PMC4886670