Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Daniel E L, Promislow"'
Autor:
Yunbi Nam, Michelle White, Elinor K Karlsson, Kate E Creevy, Daniel E L Promislow, Robyn L McClelland, Dog Aging Project Consortium
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0295840 (2024)
Age in dogs is associated with the risk of many diseases, and canine size is a major factor in that risk. However, the size patterns are complex. While small size dogs tend to live longer, some diseases are more prevalent among small dogs. In this st
Externí odkaz:
https://doaj.org/article/8d57e813de994247b6543743e18e792d
Autor:
Kiersten K. Forsyth, Brianah M. McCoy, Sarah M. Schmid, Daniel E. L. Promislow, Noah Snyder-Mackler, the DAP Consortium, Joshua M. Akey, Brooke Benton, Elhanan Borenstein, Marta G. Castelhano, Amanda E. Coleman, Kate E. Creevy, Kyle Crowder, Matthew D. Dunbar, Virginia R. Fajt, Annette L. Fitzpatrick, Unity Jeffery, Erica C Jonlin, Matt Kaeberlein, Elinor K. Karlsson, Kathleen F. Kerr, Jonathan M. Levine, Jing Ma, Robyn L McClelland, Audrey Ruple, Stephen M. Schwartz, Sandi Shrager, M. Katherine Tolbert, Silvan R. Urfer, Benjamin S. Wilfond
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionLarge scale data on the prevalence of diverse medical conditions among dog breeds in the United States are sparse. This cross-sectional study sought to estimate the lifetime prevalence of medical conditions among US dogs and to determine
Externí odkaz:
https://doaj.org/article/364df0fc30b3463485ed60d13efb7929
Autor:
Brian G. Barnett, Sonya R. Wesselowski, Sonya G. Gordon, Ashley B. Saunders, Daniel E. L. Promislow, Stephen M. Schwartz, Lucy Chou, Jeremy B. Evans, Matt Kaeberlein, Kate E. Creevy
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Introduction:Geroscience studies of low-dose rapamycin in laboratory species have identified numerous benefits, including reversing age-related cardiac dysfunction. Cardiovascular benefits have been observed in dogs with 10 weeks of treatment, raisin
Externí odkaz:
https://doaj.org/article/ef31f02892114e298f3e2dcb672c9fd0
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Differential correlation networks are increasingly used to delineate changes in interactions among biomolecules. They characterize differences between omics networks under two different conditions, and can be used to delineate mec
Externí odkaz:
https://doaj.org/article/6666197ebf04486990d54e00f62d793a
Autor:
Jessica M. Hoffman, M. Katherine Tolbert, Daniel E. L. Promislow, The Dog Aging Project Consortium, Joshua M Akey, Brooke Benton, Elhanan Borenstein, Marta G Castelhano, Amanda E Coleman, Kate E Creevy, Kyle Crowder, Matthew D Dunbar, Virginia R Fajt, Annette L Fitzpatrick, Unity Jeffery, Erica C Jonlin, Matt Kaeberlein, Elinor K Karlsson, Kathleen F Kerr, Jonathan M Levine, Jing Ma, Robyn L McClelland, Audrey Ruple, Stephen M Schwartz, Sandi Shrager, Noah Snyder-Mackler, Silvan R Urfer, Benjamin S Wilfond
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Osteoarthritis (OA) is one of the most prevalent age-related chronic conditions that afflict companion dogs, and multiple joint supplements are available to prevent or treat OA, though the efficacy of these treatments is controversial. While the demo
Externí odkaz:
https://doaj.org/article/fa849b279a3a4e0784fe4481a3c81bdd
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Lyu et al analysed metabolic network integrity in Drosophila melanogaster to assess the systemic effects of nutrient choice. By knocking out the serotonin receptor, 5-HT2A, they demonstrated that the effects of different macronutrients on the stabili
Externí odkaz:
https://doaj.org/article/3b8e0c67b3c546be951870d33a33d1f7
Publikováno v:
Canine Medicine and Genetics, Vol 7, Iss 1, Pp 1-14 (2020)
Abstract Background The privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, receives comparable me
Externí odkaz:
https://doaj.org/article/5121cc8da7f041fdbc4e6ec150c75b70
Autor:
Benjamin R. Harrison, Lu Wang, Erika Gajda, Elise V. Hoffman, Brian Y. Chung, Scott D. Pletcher, Daniel Raftery, Daniel E. L. Promislow
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Genetic association studies that seek to explain the inheritance of complex traits typically fail to explain a majority of the heritability of the trait under study. Thus, we are left with a gap in the map from genotype to phenoty
Externí odkaz:
https://doaj.org/article/bab5ffc4b2a64bb1b132c9d44a16358e
Autor:
Gary N. Landis, Tyler A. U. Hilsabeck, Hans S. Bell, Tal Ronnen-Oron, Lu Wang, Devon V. Doherty, Felicia I. Tejawinata, Katherine Erickson, William Vu, Daniel E. L. Promislow, Pankaj Kapahi, John Tower
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Background: The synthetic steroid mifepristone is reported to have anti-obesity and anti-diabetic effects in mammals on normal and high-fat diets (HFD). We previously reported that mifepristone blocks the negative effect on life span caused by mating
Externí odkaz:
https://doaj.org/article/6981a9b46ef24d029fab08fed5687e81
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Background: Interventional clinical trials intended to maintain health in aging dogs are unusual and require particular attention to exclusion criteria.Objectives: To describe reasons for exclusion when a mature adult and senior canine population wit
Externí odkaz:
https://doaj.org/article/4b9c5092102d411ab66534b4b6f7f5e3