Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniel E Eyler"'
Autor:
Jeremy Monroe, Daniel E. Eyler, Lili Mitchell, Indrajit Deb, Abigail Bojanowski, Pooja Srinivas, Christine M. Dunham, Bijoyita Roy, Aaron T. Frank, Kristin S. Koutmou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The ribosome utilizes hydrogen bonding between mRNA codons and aminoacyl-tRNAs to ensure rapid and accurate protein production. Chemical modification of mRNA nucleobases can adjust the strength and pattern of this hydrogen bonding to alter p
Externí odkaz:
https://doaj.org/article/50975c01401849b98fd36770145e907c
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174041 (2017)
Human alkyladenine DNA glycosylase (AAG) initiates base excision repair (BER) to guard against mutations by excising alkylated and deaminated purines. Counterintuitively, increased expression of AAG has been implicated in increased rates of spontaneo
Externí odkaz:
https://doaj.org/article/f2a0a7a56bae4f4bb9f2813fe3e5be79
Publikováno v:
Nature biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::324dd3dec6f76aaa68dc8c7dd5019d6a
https://pubmed.ncbi.nlm.nih.gov/36302991
https://pubmed.ncbi.nlm.nih.gov/36302991
Autor:
Meredith K. Purchal, Daniel E. Eyler, Mehmet Tardu, Monika K. Franco, Megan M. Korn, Taslima Khan, Ryan McNassor, Rachel Giles, Katherine Lev, Hari Sharma, Jeremy Monroe, Leena Mallik, Markos Koutmos, Kristin S. Koutmou
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Pseudouridine is among the most-abundant RNA modifications. We present a framework for conceptualizing how eukaryotic pseudouridine synthases select their substrates. This work reveals the structure of yeast pseudouridine synthase 7 (Pus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34614605bfb2e03ea175ec01f7d5a541
https://doi.org/10.1073/pnas.2109708119
https://doi.org/10.1073/pnas.2109708119
Autor:
Kristin S. Koutmou, Yury S. Polikanov, Daniel E. Eyler, Malgorzata Dobosz-Bartoszek, Bijoyita Roy, Monika K Franco, Joshua D. Jones, Zahra Batool, Monica Z. Wu, Michelle L. Dubuke
Publikováno v:
Proc Natl Acad Sci U S A
Chemical modifications of RNAs have long been established as key modulators of nonprotein-coding RNA structure and function in cells. There is a growing appreciation that messenger RNA (mRNA) sequences responsible for directing protein synthesis can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d9f11d9e478d8c9f5d3f9c3e4a40f2
https://doi.org/10.1073/pnas.1821754116
https://doi.org/10.1073/pnas.1821754116
Publikováno v:
The Journal of Biological Chemistry
Background: eRF3 is an essential, conserved gene, whose essential function has remained obscure. Results: eRF3 increases multiple turnover peptide release rates beyond the level expected from its stimulation of single turnover krel. Conclusion: eRF3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696e6ee4ff774d3a106114bc9cb71797
https://doi.org/10.1074/jbc.m113.487090
https://doi.org/10.1074/jbc.m113.487090
Autor:
Daniel E. Eyler, Jianhua Ju, Jun O. Liu, Ben Shen, Shridhar Bhat, Tilman Schneider-Poetsch, William C. Merrick, Yongjun Dang, Rachel Green
Publikováno v:
Nature chemical biology
Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains incompletely understood. The glutarimide portion of CHX is seen in a family of structurally related natural products incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6470e1a5b2b43124dd79d40b0cfd3d
https://doi.org/10.1038/nchembio.304
https://doi.org/10.1038/nchembio.304
Publikováno v:
Nature
Various factors associate with the ribosome to assist in initiation, elongation and termination. Textbook accounts of protein synthesis describe just two universally conserved translation elongation factors — EF-Tu/eEF1A and EF-G/eEF2. Now a study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7addb9d112c34a1ad9cab960d0e0f81b
https://doi.org/10.1038/nature08034
https://doi.org/10.1038/nature08034
Autor:
Daniel E. Eyler, Tilman Schneider-Poetsch, John C. Jewett, Viresh H. Rawal, Rachel Green, Yongjun Dang, Shridhar Bhat, Jun O. Liu
Mycalamide B (MycB) is a marine sponge-derived natural product with potent antitumor activity. Although it has been shown to inhibit protein synthesis, the molecular mechanism of action by MycB remains incompletely understood. We verified the inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa30791abd62b97b21d57890d6f690b
https://europepmc.org/articles/PMC3153980/
https://europepmc.org/articles/PMC3153980/
Autor:
Rachel Green, Daniel E. Eyler
Numerous mechanisms have evolved to control the accuracy of translation, including a recently discovered retrospective quality control mechanism in bacteria. This quality control mechanism is sensitive to perturbations in the codon:anticodon interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d62321e37b73d30b7130d3a12270a00
https://europepmc.org/articles/PMC3078741/
https://europepmc.org/articles/PMC3078741/