Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Daniel E, Knutson"'
Autor:
Ming Tatt Lee, Akihiro Mouri, Hisayoshi Kubota, Hsin-Jung Lee, Man-Hsin Chang, Chen-Yi Wu, Daniel E. Knutson, Marko Mihovilovic, James Cook, Werner Sieghart, Toshitaka Nabeshima, Lih-Chu Chiou
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 113022- (2022)
GABAA receptors containing α6 subunits (α6GABAARs) in the cerebellum have -been implicated in schizophrenia. It was reported that the GABA synthesizing enzymes were downregulated whereas α6GABAARs were upregulated in postmortem cerebellar tissues
Externí odkaz:
https://doaj.org/article/3aa12603a30d404184b76fd8bb006648
Autor:
Ya-Hsien Huang, Ming Tatt Lee, Han-Yun Hsueh, Daniel E. Knutson, James Cook, Marko D. Mihovilovic, Werner Sieghart, Lih-Chu Chiou
Publikováno v:
Neurotherapeutics. 20:399-418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c87f5eaa897f4d22e9b15658059c6cf
https://doi.org/10.1007/s13311-023-01342-y
https://doi.org/10.1007/s13311-023-01342-y
Autor:
Jelena R. Mitrović, Branka Divović-Matović, Daniel E. Knutson, Jelena B. Đoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1188 (2021)
Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation t
Externí odkaz:
https://doaj.org/article/5e2a79202ef0415b9129763a243ec430
Autor:
Elena Neumann, Uwe Rudolph, Daniel E. Knutson, Guanguan Li, James M. Cook, Harald Hentschke, Bernd Antkowiak, Berthold Drexler
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Introduction: High frequency neuronal activity in the cerebral cortex can be induced by noxious stimulation during surgery, brain injury or poisoning. In this scenario, it is essential to block cortical hyperactivity to protect the brain against dama
Externí odkaz:
https://doaj.org/article/525d2cc5199f4e32ae8a8ec99135231c
Autor:
Roberto Cadeddu, Daniel E. Knutson, Laura J. Mosher, Stefanos Loizou, Karen Odeh, Janet L. Fisher, James M. Cook, Marco Bortolato
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 175 (2021)
Tourette syndrome (TS) is a disabling neurodevelopmental disorder characterized by multiple, recurrent tics. The pharmacological treatment of TS is currently based on dopaminergic antagonists; however, these drugs are associated with extrapyramidal s
Externí odkaz:
https://doaj.org/article/34dbbd480a944e6995052f2feea4205e
Autor:
Jelena R. Mitrović, Branka Divović-Matović, Daniel E. Knutson, Miloš Petković, Djordje Djorović, Danijela V. Randjelović, Vladimir D. Dobričić, Jelena B. Đoković, Dominique J. Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić
Publikováno v:
International Journal of Pharmaceutics
Preclinical development of deuterated pyrazoloquinolinone ligands, promising drug candidates for various neuropsychiatric disorders, was hindered by unusually low solubility in water and oils. DK-I-60-3 (7-methoxy-d3- 2-(4-methoxy-d3-phenyl)-2,5-dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba74a37ed0abc76dee1f1b7859528e6b
https://cer.ihtm.bg.ac.rs/handle/123456789/5665
https://cer.ihtm.bg.ac.rs/handle/123456789/5665
Autor:
Leggy A. Arnold, Nicolas M Zahn, James M. Cook, Daniel A. Webb, Brandon N Mikulsky, Yeunus Mian, Margaret L. Guthrie, M S Rashid Roni, Douglas C. Stafford, Daniel E. Knutson
Publikováno v:
Curr Drug Metab
Background: MIDD0301 is an oral asthma drug candidate that binds GABAA receptors on airway smooth muscle and immune cells. Objective: The objective of this study is to identify and quantify MIDD0301 metabolites in vitro and in vivo and determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c0d7903e68b430c287bff185b5798d
https://doi.org/10.2174/1389200222666211202093841
https://doi.org/10.2174/1389200222666211202093841
Autor:
Etienne Sibille, James Minton Cook, Mounira Banasr, Guanguan Li, Toshifumi Tomoda, Thomas Prevot, Daniel E Knutson, Sepideh Rezvanian, Dishary Sharmin, Kamal Prasad Pandey, Yeunus Mian, PRITHU MONDAL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cdc74833d82c488e6d4ca19ff9d3c7
https://doi.org/10.1021/scimeetings.2c00466
https://doi.org/10.1021/scimeetings.2c00466
Autor:
Corey Fee, Daniel E. Knutson, Keith A. Misquitta, James M. Cook, Guanguan Li, Mounira Banasr, Etienne Sibille, Prithu Mondal, Thomas D. Prevot
Publikováno v:
International Journal of Neuropsychopharmacology
Introduction Deficits in somatostatin-positive gamma-aminobutyric acid interneurons (SST+ GABA cells) are commonly reported in human studies of mood and anxiety disorder patients. A causal link between SST+ cell dysfunction and symptom-related behavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b39e914e4e66b48e6c06e8ec35da05f
http://europepmc.org/articles/PMC8278801
http://europepmc.org/articles/PMC8278801
Autor:
M S Rashid Roni, Daniel E. Knutson, Brandon N Mikulsky, Charles W. Emala, Gene T. Yocum, Douglas C. Stafford, James M. Cook, Leggy A. Arnold, Nicolas M Zahn, Yeunus Mian
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] We report the relaxation of methacholine-constricted airways with nebulized MIDD0301, a positive allosteric γ-aminobutyric acid type A receptor (GABA(A)R) modulator. The therapeutic efficacy of nebulized MIDD0301 in reducing airway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3744488b90b6e6373ef05e6b45c2e6
https://doi.org/10.1021/acsptsci.0c00180
https://doi.org/10.1021/acsptsci.0c00180