Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Daniel E, Heinz"'
Autor:
Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A. Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T. Trussell, Katelyn X. Li, Max L. Pöhlmann, Sarah Mackert, Thomas M. Geiger, Daniel E. Heinz, Roy Lardenoije, Nina Dedic, Kenneth M. McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C. Robinson, Valentin Stein, Eicke Latz, William A. Carlezon, Felix Hausch, Mathias V. Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J. Ressler, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic moda
Externí odkaz:
https://doaj.org/article/83209dbad20940cdab3e3f6f4104353f
Autor:
Georgia Balsevich, Gavin N Petrie, Daniel E Heinz, Arashdeep Singh, Robert J Aukema, Avery C Hunker, Haley A Vecchiarelli, Hiulan Yau, Martin Sticht, Roger J Thompson, Francis S Lee, Larry S Zweifel, Prasanth K Chelikani, Nils C Gassen, Matthew N Hill
Publikováno v:
eLife, Vol 12 (2023)
Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in FAAH (FAAH C385A) reduces FAAH expression, increases anandamide levels, and increases the risk of obesity. Nevertheless, some studies have found no associati
Externí odkaz:
https://doaj.org/article/b90e4541469047cc97b6d050f23252f5
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Autor:
Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor pro
Externí odkaz:
https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057
Autor:
Nils C. Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Robert Lorenz Chua, Jakob Trimpert, Nicolas Heinemann, Christine Niemeyer, Friderike Weege, Katja Hönzke, Tom Aschman, Daniel E. Heinz, Katja Weckmann, Tim Ebert, Andreas Zellner, Martina Lennarz, Emanuel Wyler, Simon Schroeder, Anja Richter, Daniela Niemeyer, Karen Hoffmann, Thomas F. Meyer, Frank L. Heppner, Victor M. Corman, Markus Landthaler, Andreas C. Hocke, Markus Morkel, Nikolaus Osterrieder, Christian Conrad, Roland Eils, Helena Radbruch, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Externí odkaz:
https://doaj.org/article/a210cbf8766241fd8d824076b3b287b5
Autor:
Daniel E. Heinz, Vivian A. Schöttle, Paulina Nemcova, Florian P. Binder, Tim Ebert, Katharina Domschke, Carsten T. Wotjak
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice. With the help of behavioral assays, including the
Externí odkaz:
https://doaj.org/article/871cc969e65448db89a3e617199aa7f6
Autor:
Julia Ruat, Andreas J. Genewsky, Daniel E. Heinz, Sebastian F. Kaltwasser, Newton S. Canteras, Michael Czisch, Alon Chen, Carsten T. Wotjak
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104657- (2022)
Summary: Although mice mostly communicate in the ultrasonic range, they also emit audible calls. We demonstrate that mice selectively bred for high anxiety-related behavior (HAB) have a high disposition for emitting sonic calls when caught by the tai
Externí odkaz:
https://doaj.org/article/2160a04e76f14a72a457308c46145386
Autor:
Tim Ebert, Daniel E. Heinz, Suellen Almeida-Corrêa, Renata Cruz, Frederik Dethloff, Tibor Stark, Thomas Bajaj, Oriana M. Maurel, Fabiola M. Ribeiro, Silvio Calcagnini, Kathrin Hafner, Nils C. Gassen, Christoph W. Turck, Benoit Boulat, Michael Czisch, Carsten T. Wotjak
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Dementia is a devastating age-related disorder. Its therapy would largely benefit from the identification of susceptible subjects at early, prodromal stages of the disease. To search for such prognostic markers of cognitive impairment, we studied spa
Externí odkaz:
https://doaj.org/article/1c3f47f1e2ad4e5ab5d21e8c3ed79cbb
Publikováno v:
Journal of Biological Engineering, Vol 11, Iss 1, Pp 1-12 (2017)
Abstract Background Locomotor activity of rodents is an important readout to assess well-being and physical health, and is pivotal for behavioral phenotyping. Measuring homecage-activity with standard and cost-effective optical methods in mice has be
Externí odkaz:
https://doaj.org/article/22042c37bd104d738de5b15ad0bdc311
Autor:
Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Katelyn Li, Max L Pöhlmann, Daniel E Heinz, Roy Lardenoije, Nina Dedic, Kenneth M McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C. Robinson, Valentin Stein, Eicke Latz, William A Carlezon, Mathias V Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J Ressler, Nils C Gassen
Publikováno v:
bioRxiv
SummaryHigh levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. We demonstrate that secretory autophagy (SA), a non-lytic moda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ecd45553917cdd990d78b46f7a9099
https://europepmc.org/articles/PMC10103985/
https://europepmc.org/articles/PMC10103985/
Autor:
Georgia Balsevich, Gavin N Petrie, Daniel E Heinz, Arashdeep Singh, Robert J Aukema, Avery C Hunker, Haley A Vecchiarelli, Hiulan Yau, Martin Sticht, Roger J Thompson, Francis S Lee, Larry S Zweifel, Prasanth K Chelikani, Nils C Gassen, Matthew N Hill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f06a72652acb9e38b2a8d751a45ac8
https://doi.org/10.7554/elife.81919.sa2
https://doi.org/10.7554/elife.81919.sa2