Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Daniel Duche"'
Publikováno v:
Annual Review of Biomedical Engineering
The liver is the central hub of xenobiotic metabolism and consequently the organ most prone to cosmetic- and drug-induced toxicity. Failure to detect liver toxicity or to assess compound clearance during product development is a major cause of postma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76915d2450abad46f21b921a045f4f5
https://doi.org/10.1146/annurev-bioeng-060418-052305
https://doi.org/10.1146/annurev-bioeng-060418-052305
Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines
Autor:
Julie A. Skare, Shengde Wu, Carol Eisenmann, Thomas Re, Viny Srinivasan, Stephanie Ringeissen, Karen Blackburn, Daniel Duche, Donald L. Bjerke
Publikováno v:
Regulatory Toxicology and Pharmacology. 71:515-528
In the European Union animal testing has been eliminated for cosmetic ingredients while the US Cosmetic Ingredient Review Expert Panel may request data from animal studies. The use of read-across and predictive toxicology provides a path for filling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729697b4251756c08080267ad80fac52
https://doi.org/10.1016/j.yrtph.2015.01.013
https://doi.org/10.1016/j.yrtph.2015.01.013
Publikováno v:
Experimental Dermatology. 24:547-549
Skin metabolism is becoming a major consideration in the development of new cosmetic ingredients, skin being the first organ exposed to them. In order to replace limited samples of Excised human skin (EHS), in vitro engineered human skins have been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff149fed87afbc6c3eb3f425886cae26
https://doi.org/10.1111/exd.12694
https://doi.org/10.1111/exd.12694
Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations
Autor:
Ellen Fritsche, Joan Eilstein, Alain Latil, Carsten Goebel, João Barroso, Gladys Ouedraogo, Claire Moore, Daniel Duche, Kerstin Reisinger, Stefan Pfuhler, Pierre Aeby, Julia Kenny, Jochen Kuehnl, Robert Edwards, Nicola J. Hewitt, Julia Scheel, Rolf Fautz
Publikováno v:
Toxicological Sciences. 133:209-217
Several human skin models employing primary cells and immortalized cell lines used as monocultures or combined to produce reconstituted 3D skin constructs have been developed. Furthermore, these models have been included in European genotoxicity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250b3ad72d349770bec44d5d49b367b1
https://doi.org/10.1093/toxsci/kft080
https://doi.org/10.1093/toxsci/kft080
Autor:
Georges Hussler, Françoise Rousset, Jean-Pierre Lepoittevin, Joan Eilstein, Elena Giménez-Arnau, Daniel Duche, Nükhet Cavusoglu
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:5482-5489
To understand the hapten–protein complex formation in the context of skin contact allergy to p -amino aromatic derivatives, 2,5-dimethyl- p -benzoquinonediimine was used as a model compound to study the reactivity of p -benzoquinonediimines, first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92366c22466af85387377423bf5aa20
https://doi.org/10.1016/j.bmc.2008.04.014
https://doi.org/10.1016/j.bmc.2008.04.014
Autor:
Corinne Ferraris, Van Luu-The, Fernand Labrie, Daniel Duche, Patrick Bélanger, Jacques Leclaire
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 107:30-36
The skin is a well-recognized site of steroid formation and metabolism. Episkin is a cultured human epidermis. In this report, we investigate whether Episkin possesses a steroidogenic machinery able to metabolize adrenal steroid precursors into activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d655f4cfee00cc04ffba21a11722ae27
https://doi.org/10.1016/j.jsbmb.2007.03.036
https://doi.org/10.1016/j.jsbmb.2007.03.036
Autor:
Gerhard J. Nohynek, Alexia Garrigues, Jacques Leclaire, Hervé Toutain, Pierre-Alain Meunier, Daniel Duche
Publikováno v:
Toxicology Letters. 158:196-212
We investigated the biotransformation of the oxidative arylamine (AA) hair dye ingredients [14C]-para-aminophenol (PAP) and [14C]-para-phenylenediamine (PPD) in reconstructed human epidermis and human hepatocytes. Human epidermis quantitatively trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b19d4eb0173b280a7902743189f706
https://doi.org/10.1016/j.toxlet.2005.03.014
https://doi.org/10.1016/j.toxlet.2005.03.014
Autor:
Gary D. Minsavage, Colleen Toole, Mark I. Avigan, Kalyanasundaram Subramanian, Brigitte Landesmann, Imran Shah, Marilyn Matevia, John R. Senior, Paul B. Watkins, Mathieu Vinken, Andre Kleensang, Melvin E. Andersen, Katy O. Goyak, Carl Westmoreland, Jennifer Seed, Daniel Duche, Andrew N. Rowan, Terry W Schultz, Catherine Willett, Thomas Hartung, Hartmut Jaeschke, Georgina Harris, Jessica Caverly Rae, Suzanne N. Martos
Publikováno v:
ALTEX. 31(4)
A workshop sponsored by the Human Toxicology Project Consortium (HTPC), "Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action" brought together experts from a wide range of perspective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff63553f0d0addddacd1b51a6b341dd
https://pubmed.ncbi.nlm.nih.gov/24535319
https://pubmed.ncbi.nlm.nih.gov/24535319
Autor:
Natali Budimir, Daniel Duche, Georges Hussler, Simon Wilkinson, Guillaume Lereaux, Joan Eilstein
Publikováno v:
Archives of toxicology. 88(9)
Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been developed to replace limited ex vivo normal human skin sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c93353a3e9906cd59711651ded53c7
https://pubmed.ncbi.nlm.nih.gov/24658324
https://pubmed.ncbi.nlm.nih.gov/24658324
Autor:
Jacques Leclaire, Jean-Roch Meunier, Fernand Labrie, Daniel Duche, Corinne Ferraris, Van Luu-The
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 116(3-5)
Background Episkin™ and full thickness model from Episkin™ (FTM) are human skin models obtained from in vitro growth of keratinocytes into the five typical layers of the epidermis. FTM is a full thickness reconstructed skin model that also contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02bc7e29604d84658f38ef77422e0a1
https://pubmed.ncbi.nlm.nih.gov/19482084
https://pubmed.ncbi.nlm.nih.gov/19482084