Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Daniel Dube"'
Autor:
Andi Alijagic, Lisanna Sinisalu, Daniel Duberg, Oleksandr Kotlyar, Nikolai Scherbak, Magnus Engwall, Matej Orešič, Tuulia Hyötyläinen
Publikováno v:
Environment International, Vol 190, Iss , Pp 108820- (2024)
PFAS are ubiquitous industrial chemicals with known adverse health effects, particularly on the liver. The liver, being a vital metabolic organ, is susceptible to PFAS-induced metabolic dysregulation, leading to conditions such as hepatotoxicity and
Externí odkaz:
https://doaj.org/article/fea040b5f78746408b3a533e7e80932a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The hunger for a better, more effective, more economic, easier for construction, and overall more sustainable bridge design is enormous nowadays. One of the solutions for the problems described is a steel-concrete composite structure with em
Externí odkaz:
https://doaj.org/article/c4c35fa0ade74b119259fb340899af84
Autor:
Kelly Bleasby, Dwight Macdonald, Bruce Mackay, Richard Tschirret-Guth, Robert Houle, Sebastien Laliberte, Patrick Lacombe, Robert Papp, Erich L. Grimm, Amandine Chefson, Jean-François Lévesque, Michael J. Hafey, Pierre-André Fournier, Sébastien Gagné, Yongxin Han, Yves Ducharme, Michel Gallant, Austin Chen, Daniel Dube
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5547-5551
An oral bioavailability issue encountered during the course of lead optimization in the renin program is described herein. The low F(po) of pyridone analogs was shown to be caused by a combination of poor passive permeability and gut efflux transport
Autor:
Stephen M. Soisson, Tom Y.-H. Wu, Michel Gallant, Austin Chen, Dwight Macdonald, Daniel Dube, Robert Houle, Jean-Pierre Falgueyret, Renee Aspiotis, Dan McKay, Jean-François Lévesque, Patrick Roy, Helene Juteau, Sébastien Gagné, M. David Percival, Erich L. Grimm, Sebastien Laliberte, Patrick Lacombe, Elizabeth Cauchon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2430-2436
The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-de
Autor:
Christopher I. Bayly, Dan McKay, Tom Y.-H. Wu, Patrick Roy, Suzanna Liu, Michel Gallant, Austin Chen, Helene Juteau, Rejean Fortin, Daniel Dube, Renee Aspiotis, Patrick Lacombe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5822-5826
The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the cyclopropylamide spacer present in 1 can be replaced by a simple, substituted aromatic ring suc
Autor:
Ilias Thomas, Alex M. Dickens, Jussi P. Posti, Endre Czeiter, Daniel Duberg, Tim Sinioja, Matilda Kråkström, Isabel R. A. Retel Helmrich, Kevin K. W. Wang, Andrew I. R. Maas, Ewout W. Steyerberg, David K. Menon, Olli Tenovuo, Tuulia Hyötyläinen, András Büki, Matej Orešič, CENTER-TBI Participants and Investigators
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Traumatic brain injury is associated with changes to the metabolome. Here the authors show that acute traumatic brain injury has distinctive serum metabolic patterns which may suggest protective changes of systemic lipid metabolism aiming to maintain
Externí odkaz:
https://doaj.org/article/5647d4f3026c469abc78664e5c748a91
Autor:
F. Otu, Joseph A. Mancini, Dwight Macdonald, Rebecca Dias, Daniel Dube, L. Zhang, Patrick Lacombe, Pascal Jean Denis Goetghebeur, Angela Styhler, David Claveau, Suzanna Liu, Yves Girard, Zheng Huang, Mervyn J. Turner, Michel Gallant, William M. Abraham, K. Ng, Thomas R. Jones, F. Laliberte, Robert N. Young, Donald W. Nicholson
Publikováno v:
Biochemical Pharmacology. 73:1971-1981
Type 4 phosphodiesterases (PDE4) inhibitors are emerging therapeutics in the treatment of a number of chronic disorders including asthma, chronic obstructive pulmonary disease (COPD) and cognitive disorders. This study delineates the preclinical prof
Publikováno v:
Intelligent Autonomous Systems 13 ISBN: 9783319083377
3D sensors are used for many different applications, e.g., scene reconstruction, object detection, and mobile robots, etc. Several studies on usability and accuracy have been done for different sensors. However, all these studies have used different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb6a407a6059edb83f29cc235cace050
https://doi.org/10.1007/978-3-319-08338-4_3
https://doi.org/10.1007/978-3-319-08338-4_3
Autor:
Yves Girard, Dwight Macdonald, Deborah A. Nicoll-Griffith, Michel Gallant, Nathalie Chauret, Daniel Dube, Anthony Mastracchio, Laird A. Trimble, Kevin P. Bateman, José M. Silva, Stephen Day, Helene Perrier
Publikováno v:
Journal of Mass Spectrometry. 41:771-780
L-454,560 is a potent phospodiesterase 4 (PDE4) inhibitor which was identified as a development candidate for the treatment of asthma and chronic obstructive pulmonary disease (COPD). As part of the discovery of this compound, interspecies in vitro m
Autor:
Christine Brideau, Richard Friesen, Yves Girard, Chantal Savoie, Chi-Chung Chan, Daniel Dube, Rejean Fortin, Denis Riendeau, Robert Gordon, Denis Deschenes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1715-1720
A series of novel 2-alkoxy, 2-thioalkoxy and 2-amino-3-(4-methylsulfonyl)phenylpyridines has been synthesized and shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. Structure-activity relationship studies have demonstrated t