Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Daniel Ditzel Santos"'
Autor:
Arlene H. Sharpe, Giulia Notarangelo, Steven P. Gygi, Jonathan M. Ghergurovich, F. Kyle Satterstrom, Marcia C. Haigis, Peter T. Sage, Noga Ron-Harel, Joao A. Paulo, Daniel Ditzel Santos, Joshua D. Rabinowitz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance T cell-mediated immune responses are compromised in aged individuals, leading to increased morbidity and reduced response to vaccination. Finding new ways to boost T cell immunity in the elderly is key for enhancing their immune competen
Autor:
David T. Scadden, Haejin Yoon, Wilhelm Haas, Daniel Ditzel Santos, Rushdia Z. Yusuf, F. Kyle Satterstrom, Marcia C. Haigis, Lydia W.S. Finley, Natalie J. German, Andrew H. Beck, J. Patrick Murphy, William G. Kaelin, Jlenia Guarnerio, Elma Zaganjor, Steven P. Gygi, Pier Paolo Pandolfi, Gaëlle Laurent
Publikováno v:
Molecular Cell. 63:1006-1020
While much research has examined the use of glucose and glutamine by tumor cells, many cancers instead prefer to metabolize fats. Despite the pervasiveness of this phenotype, knowledge of pathways that drive fatty acid oxidation (FAO) in cancer is li
Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
Autor:
Arlene H. Sharpe, Noga Ron-Harel, Steven P. Gygi, Peter T. Sage, Joshua D. Rabinowitz, Anita Reddy, Scott B. Lovitch, Noah Dephoure, Jessica B. Spinelli, Jonathan M. Ghergurovich, F. Kyle Satterstrom, Marcia C. Haigis, Michal Sheffer, Daniel Ditzel Santos
Publikováno v:
Cell Metabolism. 24:104-117
Naive T cell stimulation activates anabolic metabolism to fuel the transition from quiescence to growth and proliferation. Here we show that naive CD4(+) T cell activation induces a unique program of mitochondrial biogenesis and remodeling. Using mas
Advancing age is the major risk factor for the development of chronic diseases and is accompanied by changes in metabolic processes and mitochondrial dysfunction. Mitochondrial sirtuins (SIRT3–5) are part of the sirtuin family of NAD + -dependent d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd9ed2a4d09caa923751e7ef8623e78
https://europepmc.org/articles/PMC5713479/
https://europepmc.org/articles/PMC5713479/
Autor:
Daniel Ditzel Santos, Aaron Middlebrook, Friedrich Hahn, Mitchell Ferguson, Warren Porter, Caitlin Austin, Eileen Snowden, Rainer Blaesius, Smita Ghanekar
Publikováno v:
Cancer Research. 78:2113-2113
The heterogeneous nature of solid tumors, coupled with the relatively small sample size of available biopsies, has led to an emerging need to glean as much information as possible from these valuable specimens. Current approaches to solid tumor analy
Autor:
Christopher J. Patterson, Steven P. Treon, Xavier Leleu, Irene M. Ghobrial, Evdoxia Hatjiharissi, Jacob D. Soumerai, Vinod Bakthavachalam, Zachary R. Hunter, Allen W. Ho, Sigitas Verselis, Edward A. Fox, Ruben D. Carrasco, Aldo M. Roccaro, Robert Manning, Anne-Sophie Moreau, Susanna Hamilton, Sophia Adamia, Daniel Ditzel Santos, Lian Xu
Publikováno v:
British Journal of Haematology. 145:59-63
Waldenstrom Macroglobulinemia (WM) is a B-cell malignancy characterized by excess bone marrow (BM) lymphoplasmacytic cells (LPC). The accumulation of LPC in WM may represent a failure of B-cells to properly differentiate into plasma cells. The presen
Autor:
Edward A. Fox, Steven P. Treon, Alexandros Kortsaris, Mark Hansen, Daniel Ditzel Santos, Christopher J. Patterson, Sigitas Verselis, Zachary R. Hunter, Evdoxia Hatjiharissi, Xavier Leleu, Elizabeth W. Dimmock, Allen W. Ho, Andrew R. Branagan, Lian Xu
Publikováno v:
Clinical Cancer Updates. 1:74-78
Autor:
Christopher J. Patterson, Robert Manning, Evdoxia Hatjiharissi, Cao Yang, Jacob D. Soumerai, Zachary R. Hunter, Antonio Sacco, Lian Xu, Bryan Ciccarelli, Allen W. Ho, Andrew R. Branagan, Olivier Tournilhac, Irene M. Ghobrial, Hai T. Ngo, Kelly O’Connor, Xavier Leleu, Steven P. Treon, Aldo M. Roccaro, Sophia Adamia, Daniel Ditzel Santos, Xiaoying Jia, Marybeth Nelson, Renee Leduc, Anne-Sophie Moreau
Publikováno v:
Clinical Lymphoma and Myeloma. 7:S199-S206
Waldenström's macroglobulinemia is a B-cell disorder characterized by bone marrow infiltration with lymphoplasmacytic cells and demonstration of an immunoglobulin M monoclonal gammopathy. Despite advances in therapy, Waldenström's macroglobulinemia
Autor:
Jeffery L. Kutok, Olivier Tournilhac, Lian Xu, Steven P. Treon, Zachary R. Hunter, Elizabeth A. Dimmock, Daniel Ditzel Santos, Allen W. Ho, Mariana Castells, Evdoxia Hatjiharissi, Xavier Leleu, Andrew R. Branagan, Robert Manning, Winthrop H. Churchill, Kenneth C. Anderson, Mariana Chemaly, Yu-Tzu Tai, Christopher J. Patterson
Publikováno v:
Clinical Lymphoma and Myeloma. 6:478-483
Background Alemtuzumab is a monoclonal antibody used in the treatment of CD52-expressing B-cell malignancies, including Waldenstrom's macroglobulinemia (WM). Recent studies demonstrate high levels of alemtuzumab activity in relapsed/refractory diseas
Autor:
Paola Neri, Kenneth C. Anderson, Daniel Ditzel Santos, Salvatore Venuta, Vidit Munshi, Evdoxia Hatjiharissi, Pierfrancesco Tassone, Nikhil C. Munshi, Olivier Tournilhac, Jeffery L. Kutok, Steven P. Treon
Publikováno v:
Blood. 106:1341-1345
The preclinical evaluation of investigational agents for Waldenström macroglobulinemia (WM) has been limited by the lack of in vivo models that enable the use of explanted patient cells. We describe here a novel in vivo model of human WM in severe