Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Daniel Deredge"'
Autor:
Beatriz Trastoy, Jonathan J. Du, Javier O. Cifuente, Lorena Rudolph, Mikel García-Alija, Erik H. Klontz, Daniel Deredge, Nazneen Sultana, Chau G. Huynh, Maria W. Flowers, Chao Li, Diego E. Sastre, Lai-Xi Wang, Francisco Corzana, Alvaro Mallagaray, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Here, the authors establish the mechanisms of recognition and specific deglycosylation of IgG antibodies by
Externí odkaz:
https://doaj.org/article/7aed46f3a16540f68a93f7c72eef2df7
Autor:
Caroline N Smith, Kyle Kihn, Zachary A Williamson, K Martin Chow, Louis B Hersh, Konstantin V Korotkov, Daniel Deredge, Jessica S Blackburn
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285964 (2023)
Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and metastasis. The mechanisms that drive PRL-3's oncogenic functions are not well understood, partly due to a lack of research tools available to study this protein. W
Externí odkaz:
https://doaj.org/article/f688ec8b8a0a4c2b94b6ee1357dbd491
Autor:
Erik H. Klontz, Chao Li, Kyle Kihn, James K. Fields, Dorothy Beckett, Greg A. Snyder, Patrick L. Wintrode, Daniel Deredge, Lai-Xi Wang, Eric J. Sundberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
AlfC transfucosidase is used to modulate fucosylation of glycans decorating monoclonal antibodies. Herein, structural and biophysical characterization reveals the enzymatic mechanism of AlfC and a blueprint for the design of AlfC mutants with novel s
Externí odkaz:
https://doaj.org/article/9a30450512214f37b47bbcf6f541a3c3
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor
Autor:
James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz, Kjell Sjöström, Sebastian Günther, Robert Beadenkopf, Göran Forsberg, David Liberg, Greg A. Snyder, Daniel Deredge, Eric J. Sundberg
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflamma
Externí odkaz:
https://doaj.org/article/d1aa83cba4b9429da818f4c99e7a5c77
Autor:
Asaminew H Aytenfisu, Daniel Deredge, Erik H Klontz, Jonathan Du, Eric J Sundberg, Alexander D MacKerell
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009103 (2021)
Antibodies bind foreign antigens with high affinity and specificity leading to their neutralization and/or clearance by the immune system. The conserved N-glycan on IgG has significant impact on antibody effector function, with the endoglycosidases o
Externí odkaz:
https://doaj.org/article/1c5a1fb3a1a0497cac4852104caef0b6
Autor:
Erik H. Klontz, Beatriz Trastoy, Daniel Deredge, James K. Fields, Chao Li, Jared Orwenyo, Alberto Marina, Robert Beadenkopf, Sebastian Günther, Jair Flores, Patrick L. Wintrode, Lai-Xi Wang, Marcelo E. Guerin, Eric J. Sundberg
Publikováno v:
ACS Central Science, Vol 5, Iss 3, Pp 524-538 (2019)
Externí odkaz:
https://doaj.org/article/004711398bcc42978684ed40020eff2d
Autor:
Sandra Postel, Daniel Deredge, Daniel A Bonsor, Xiong Yu, Kay Diederichs, Saskia Helmsing, Aviv Vromen, Assaf Friedler, Michael Hust, Edward H Egelman, Dorothy Beckett, Patrick L Wintrode, Eric J Sundberg
Publikováno v:
eLife, Vol 5 (2016)
Flagella are crucial for bacterial motility and pathogenesis. The flagellar capping protein (FliD) regulates filament assembly by chaperoning and sorting flagellin (FliC) proteins after they traverse the hollow filament and exit the growing flagellum
Externí odkaz:
https://doaj.org/article/bee7c0a8aa6d4f5a84b1d0eee2a39ce4
Autor:
Haarin Chun, James H. Kurasawa, Philip Olivares, Ekaterina S. Marakasova, Svetlana A. Shestopal, Gabriela U. Hassink, Elena Karnaukhova, Mary Migliorini, Juliet O. Obi, Ally K. Smith, Patrick L. Wintrode, Prasannavenkatesh Durai, Keunwan Park, Daniel Deredge, Dudley K. Strickland, Andrey G. Sarafanov
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2255-2269
Deficiency in blood coagulation factor VIII (FVIII) results in life-threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve disease treatment, FVIII has been modified to increase its plasma half-life, which requires u
Autor:
Erik Klontz, Juliet O. Obi, Yajing Wang, Gabrielle Glendening, Jahid Carr, Constantine Tsibouris, Sahthi Buddula, Shreeram Nallar, Alexei S. Soares, Dorothy Beckett, Jasmina S. Redzic, Elan Eisenmesser, Cheyenne Palm, Katrina Schmidt, Alexis H. Scudder, Trinity Obiorah, Kow Essuman, Jeffrey Milbrandt, Aaron Diantonio, Krishanu Ray, Daniel Deredge, M LD. Snyder, Greg A. Snyder
Toll-like and Interleukin-1/18 receptor resistance (TIR) domain-containing proteins function as important signaling and immune regulatory molecules. TIR domain-containing proteins identified in eukaryotic and prokaryotic species also exhibit NAD+ hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95374451370e60151b3cff10b9ddcf36
https://doi.org/10.1101/2023.05.19.541320
https://doi.org/10.1101/2023.05.19.541320
Autor:
Upneet Kaur, Kyle C. Kihn, Haiping Ke, Weiwei Kuo, Lila M. Gierasch, Daniel N. Hebert, Patrick L. Wintrode, Daniel Deredge, Anne Gershenson
Many multi-domain proteins including the serpin family of serine protease inhibitors contain non-sequential domains composed of regions that are far apart in sequence. Because proteins are translated vectorially from N-to C-terminus, such domains pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2de98a94a1a2dfc8cfa68e0d48ae20c
https://doi.org/10.1101/2023.04.24.537978
https://doi.org/10.1101/2023.04.24.537978