Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Daniel De Sloover"'
Autor:
Kara N. Maxwell, Bradley Wubbenhorst, Brandon M. Wenz, Daniel De Sloover, John Pluta, Lyndsey Emery, Amanda Barrett, Adam A. Kraya, Ioannis N. Anastopoulos, Shun Yu, Yuchao Jiang, Hao Chen, Nancy R. Zhang, Nicole Hackman, Kurt D’Andrea, Robert Daber, Jennifer J. D. Morrissette, Nandita Mitra, Michael Feldman, Susan M. Domchek, Katherine L. Nathanson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Most tumours associated with germline BRCA1/BRCA2 loss of function mutations respond to DNA damaging agents, however, some do not. Herein, the authors identify that a subset of breast/ovarian tumors retain a normal allele, which is associated with de
Externí odkaz:
https://doaj.org/article/0f6f94b247c0462089e5fb392de747ba
Autor:
Hao Chen, Nicole M. Hackman, Michael Feldman, Yuchao Jiang, Kurt D'Andrea, Katherine L. Nathanson, Lyndsey Emery, Nandita Mitra, Kara N. Maxwell, Daniel De Sloover, John Pluta, Brandon Wenz, Susan M. Domchek, Jennifer J.D. Morrissette, Adam A. Kraya, Ioannis N. Anastopoulos, Nan Zhang, Shun Yu, Amanda Barrett, Bradley Wubbenhorst, Robert Daber
Publikováno v:
Nature Communications
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all BRCA1 and BRCA2 germline mutation-associated tumors respond. Herein we report analyses of 160 BRCA1 and BRCA2 germline mutation-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d339124e26455744fe297735bbe5ac1
https://pubmed.ncbi.nlm.nih.gov/28831036
https://pubmed.ncbi.nlm.nih.gov/28831036
Autor:
Adam A. Kraya, Michael Feldman, Bradley Wubbenhorst, Amanda Barrett, Katherine L. Nathanson, Jennifer J.D. Morrissette, Brandon Wenz, Susan Domcheck, Nicole Lunceford, Kara N. Maxwell, Daniel De Sloover, Robert H. Vonderheide
Publikováno v:
Cancer Immunology Research. 5:A12-A12
Germline mutations in BRCA1 or BRCA 2 can lead to increased genomic instability and mutational burden in mutation-associated breast and ovarian cancer. Given the association of tumor neoepitope load and clinical response to immune checkpoint therapy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273cfd0f6df0ae78279a01519671e8b7
https://doi.org/10.1158/2326-6074.tumimm16-a12
https://doi.org/10.1158/2326-6074.tumimm16-a12