In vitro activity of some flavonoid derivatives on human leukemic myeloid cells: evidence for aminopeptidase-N (CD13) inhibition, antiproliferative and cell death properties

Autor: Brigitte Bauvois, Daniel Dauzonne, Marion Piedfer, Santos Susin, Sandrine Bouchet

Publikováno v: AIMS Molecular Science, Vol 3, Iss 3, Pp 368-385 (2016)

Leukemia cells from patients with acute myeloid leukemia (AML) display high proliferative capacity and are resistant to death. Membrane-anchored aminopeptidase-N/CD13 is a potential drug target in AML. Clinical research efforts are currently focusing

Externí odkaz: https://doaj.org/article/a3cbedf537344e4a959ff5dbe895b997

Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells

Autor: Dany Pechalrieu, Paola B. Arimondo, Marie Lopez, Daniel Dauzonne

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, pp.111829. ⟨10.1016/j.ejmech.2019.111829⟩
European Journal of Medicinal Chemistry, 2020, pp.111829. ⟨10.1016/j.ejmech.2019.111829⟩

International audience; The implication of DNA methylation in cancer is today clearly established. Despite that nucleoside analogues are currently used for leukaemia treatment, their low stability in physiological conditions and their lack of selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0b7fb59aab4b6307a927ff74bd087d
https://pubmed.ncbi.nlm.nih.gov/31757526

Enantioselective Organocatalyzed Consecutive Synthesis of Alkyl 4,5-Dihydrofuran-2-carboxylates from α-Keto Esters and (Z)-β-Chloro-β-nitrostyrenes

Autor: Daniel Dauzonne, Damien Bonne, Diana Becerra, Jean Rodriguez, Thierry Constantieux, Wilfried Raimondi

Publikováno v: SYNTHESIS
SYNTHESIS, Georg Thieme Verlag, 2016, 49 (01), pp.195-201. ⟨10.1055/s-0035-1562446⟩
SYNTHESIS, Georg Thieme Verlag, 2016, 49 (01), pp.195-201. 〈10.1055/s-0035-1562446〉
Synthesis: Journal of Synthetic Organic Chemistry
Synthesis: Journal of Synthetic Organic Chemistry, 2016, 49 (01), pp.195-201. ⟨10.1055/s-0035-1562446⟩
Illustration. France. 2016

International audience; Alkyl 4,5-dihydrofuran-2-carboxylates can be efficiently ob- tained via an enantioselective organocatalyzed consecutive reaction between _-keto esters and (Z)-(2-chloro-2-nitroethenyl)benzenes. The overall sequence combines a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27287203722206a53c76bc7606aff81c
https://doi.org/10.1055/s-0035-1562446

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

Autor: Marianne Lucas-Hourani, Philippe V. Afonso, Julien Dairou, Frédéric Tangy, Olivier Helynck, Sébastien Nisole, Daniel Dauzonne, Hélène Munier-Lehmann, Samira Khiar, Pierre-Olivier Vidalain

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (10), pp.e00383-17. ⟨10.1128/AAC.00383-17⟩
Antimicrobial Agents and Chemotherapy, 2017, 61 (10), pp.e00383-17. ⟨10.1128/AAC.00383-17⟩

De novo pyrimidine biosynthesis is a key metabolic pathway involved in multiple biosynthetic processes. Here, we identified an original series of 3-(1 H -indol-3-yl)-2,3-dihydro-4 H -furo[3,2- c ]chromen-4-one derivatives as a new class of pyrimidine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9e7075e9cb9e986caf5f8a8f5c8eeb
https://pubmed.ncbi.nlm.nih.gov/28807907

Physicochemical properties of exogenous molecules correlated with their biological efficacy as protectors against carcinogenesis and inflammation

Autor: René V. Bensasson, Chérif F. Matta, Daniel Dauzonne, Shahin Sowlati-Hashjin, Vincent Zoete

Publikováno v: International Reviews in Physical Chemistry. 32:393-434

A large number of molecules referred to here as M, several of which are extracted from plants, belong to different chemical classes and exhibit chemoprotective activity against carcinogenesis and inflammation in rodents and in vitro cell culture. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4668b17452366e498322f6bb6102b3c3
https://doi.org/10.1080/0144235x.2013.767669