Výsledky vyhledávání - "Daniel D. Wiant"

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Publikováno v: Journal of Medicinal Chemistry. 51:5893-5896

Selective delta opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening. Subsequent lead optimization iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619e8cbfdd85472b2463e048206eebc5
https://doi.org/10.1021/jm8008986

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Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles

Autor: Roland E. Dolle, Diane L. DeHaven-Hudkins, Daniel D. Wiant, Joel A. Cassel, William M. Barker, Patrick J. Little, Bertrand Le Bourdonnec, Robert N. DeHaven, Serge Belanger, Nathalie Conway-James, Timothy J. O’Neill

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:2006-2012

A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, mu opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective mu opioid recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26c41c2d45b977ff06a701c18afedae
https://doi.org/10.1016/j.bmcl.2008.01.106

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Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747)

Publikováno v: Journal of medicinal chemistry. 52(18)

Selective, nonpeptidic delta opioid receptor agonists have been the subject of great interest as potential novel analgesic agents. The discoveries of BW373U86 (1) and SNC80 (2) contributed to the rapid expansion of research in this field. However, po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc53d00daff04ac1abedc34cfddc85c
https://pubmed.ncbi.nlm.nih.gov/19694468

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Akademický článek

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747).

Publikováno v: Journal of Medicinal Chemistry; Sep2009, Vol. 52 Issue 18, p5685-5702, 18p

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