Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Daniel D. Waller"'
Autor:
Natasha Kekre, Kevin A. Hay, John R. Webb, Ranjeeta Mallick, Miruna Balasundaram, Mhairi K. Sigrist, Anne-Marie Clement, Julie S. Nielsen, Jennifer Quizi, Eric Yung, Scott D. Brown, Lisa Dreolini, Daniel D. Waller, Julian Smazynski, Nicole S. Gierc, Bianca C. Loveless, Kayla Clark, Tyler Dyer, Richard Hogg, Leah McCormick, Michael Gignac, Shanti Bell, D. Maria Chapman, David Bond, Siao Yong, Rachel Fung, Heather M. Lockyer, Victoria Hodgson, Catherine Murphy, Ana Subramanian, Evelyn Wiebe, Piriya Yoganathan, Liana Medynski, Dominique C. Vaillan, Alice Black, Sheryl McDiarmid, Michael Kennah, Linda Hamelin, Kevin Song, Sujaatha Narayanan, Judith A. Rodrigo, Stefany Dupont, Terry Hawrysh, Justin Presseau, Kednapa Thavorn, Manoj M. Lalu, Dean A. Fergusson, John C. Bell, Harold Atkins, Brad H. Nelson, Robert A. Holt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Access to commercial CD19 CAR-T cells remains limited even in wealthy countries like Canada due to clinical, logistical, and financial barriers related to centrally manufactured products. We created a non-commercial academic platform for end-to-end m
Externí odkaz:
https://doaj.org/article/ba9bb5ccb69a4646aee78f29aa8e0137
Autor:
Wee-Joo Chng, Michael Sebag, Daniel D. Waller, Qi Zeng, Zea Tuan Tan, Tae-Hoon Chung, Jing-Yuan Chooi, Yan Ting Hee, Julia S.L. Lim, Jianbiao Zhou, Phyllis S.Y. Chong
Table S1: RT-PCR primers Figure S1: mRNA and protein expression of PRL-3 in HMCLs. Figure S2. IL-6 treatment of MM cell lines. Figure S3. Cellular effects of PRL-3 knockdown in HMCLs. Figure S4. Treatment of BTZ-resistant cells with PRL-3 inhibitor I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e934dc13d07109ecfabbd698dd1cd4
https://doi.org/10.1158/0008-5472.22421531
https://doi.org/10.1158/0008-5472.22421531
Autor:
Wee-Joo Chng, Michael Sebag, Daniel D. Waller, Qi Zeng, Zea Tuan Tan, Tae-Hoon Chung, Jing-Yuan Chooi, Yan Ting Hee, Julia S.L. Lim, Jianbiao Zhou, Phyllis S.Y. Chong
Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic activities of PRL-3 in multiple myeloma warrant further investigation. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31066edb2b06953929b10ec839abaea9
https://doi.org/10.1158/0008-5472.c.6510956
https://doi.org/10.1158/0008-5472.c.6510956
Autor:
Hiu-Fung Lee, Cyrus M. Lacbay, Rebecca Boutin, Alexios N. Matralis, Jaeok Park, Daniel D. Waller, Tian Lai Guan, Michael Sebag, Youla S. Tsantrizos
Publikováno v:
Journal of Medicinal Chemistry. 65:2471-2496
Novel analogues of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective ap
Autor:
Marta Chesi, Laura M. Richards, Daniel D Waller, Serges P Tsofack, Ellen Nong Wei, P. Leif Bergsagel, Suzanne Trudel, Danielle C Croucher, Xian Fang Huang, Michael Sebag, Trevor J. Pugh, Zhihua Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Molecular programs that underlie precursor progression in multiple myeloma are incompletely understood. Here, we report a disease spectrum-spanning, single-cell analysis of the Vκ*MYC myeloma mouse model. Using samples obtained from mice with serolo
Publikováno v:
Leukemia & Lymphoma. 61:1724-1727
Lenalidomide maintenance following autologous stem cell transplantation (ASCT) has emerged as the preferred treatment option for newly diagnosed patients with multiple myeloma (MM). Two large rando...
Autor:
P. Leif Bergsagel, Zhihua Li, Danielle C Croucher, Daniel D Waller, Michael Sebag, Trevor J. Pugh, Xian Fang Huang, Laura M. Richards, Marta Chesi, Suzanne Trudel
Multiple myeloma is universally preceded by a premalignant disease state. However, efforts to develop preventative therapeutic strategies are hindered by an incomplete understanding of the immune mechanisms associated with progression. Using single-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f4f0bde998c2cc68a178052c421bf5
https://doi.org/10.1101/2021.10.22.464971
https://doi.org/10.1101/2021.10.22.464971
Autor:
Jennifer Chu, Rayelle Itoua Maïga, Daniel D Waller, Lauren E. Brown, William G. Devine, Jerry Pelletier, John A. Porco, Wenhan Zhang, Michael Sebag, Regina Cencic
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Translation is a highly regulated process that is perturbed in human cancers, often through activation of the PI3K/mTOR pathway which impacts directly on the ribosome recruitment phase of translation initiation. While significant research has focused
Autor:
Félix Vincent, Mònica Gómez Palou, Jaeok Park, Michael Sebag, Albert M. Berghuis, Youla S. Tsantrizos, Viviane Ta, Cyrus M. Lacbay, Daniel D Waller, Xian Fang Huang
Publikováno v:
Journal of Medicinal Chemistry. 61:6904-6917
Post-translational prenylation of the small GTP-binding proteins (GTPases) is vital to a plethora of biological processes, including cellular proliferation. We have identified a new class of thienopyrimidine-based bisphosphonate (ThP-BP) inhibitors o
Publikováno v:
Critical reviews in biochemistry and molecular biology. 54(1)
Dysregulation of isoprenoid biosynthesis is implicated in numerous biochemical disorders that play a role in the onset and/or progression of age-related diseases, such as hypercholesterolemia, osteoporosis, various cancers, and neurodegeneration. The