Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel D. Comer"'
Autor:
Jutta Glock, Peter D. J. Grootenhuis, Steven Bondy, Daniel D. Comer, Soan Cheng, Arthur Steiger, Martin Zeller, Grit Laue, Adrian Friedmann, Olivier Jacob, Mafalda Nina, Hans-Jürg Widmer, Klaus Kreuz, Julie E. Penzotti, Hans Brunner, James Allen, Thierry Niderman, Hans Ulrich Haas, Renold Chollet, Martin Eberle, Peter Renold, William Lutz, Jürg Ehrler, Marian Valentini, Markus Walti, Evelyne Sieger, Thomas Vettiger, G. Wayne Craig
Publikováno v:
CHIMIA, Vol 62, Iss 1-2 (2008)
The search for new active molecules with novel modes of action and desirable physical properties is an ongoing endeavour. This publication describes the follow-up chemistry of a biological hit discovered in the screening system of Novartis Crop Prote
Externí odkaz:
https://doaj.org/article/5c120d9f6ae7458abd6d1d641fce6442
Autor:
Imai Minoru, Peter Myers, Kenichiro Kataoka, Takaharu Tsutsumi, Michele M. Ramirez-Weinhouse, Noriaki Endo, Chung-Ming Sun, Masaki Sudo, Jonathan W. Greene, Wilna J. Moree, Doug Barnum, Tatsuki Shiota, Hada Takahiko, Hiroko Tanaka, Shinsuke Yamagami, Yoshinori Kato, Christine M. Tarby, John Saunders, Morita Takuya, Daniel D. Comer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5407-5411
N , N ′-Disubstituted homopiperazine derivatives have been discovered as CC-chemokine receptor 2b (CCR2b) inhibitors with submicromolar activity in the CCR2b binding assay. A 4-substituted benzyl group on one homopiperazine nitrogen was an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a49e3bbd69f9052acdf42678fab1ecc
https://doi.org/10.1016/j.bmcl.2004.08.008
https://doi.org/10.1016/j.bmcl.2004.08.008
Publikováno v:
Tetrahedron Letters. 40:8975-8978
Liquid phase parallel synthesis has been developed to synthesize a novel series of iminodiacetic acid derivatives targeting the integrin receptors. This library was synthesized using a four-step reaction sequence. In each step of the sequence, the PE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481cc3ec9b05f008266fa30d054965df
https://doi.org/10.1016/s0040-4039(99)01915-2
https://doi.org/10.1016/s0040-4039(99)01915-2
Publikováno v:
Journal of the American Chemical Society. 118:2567-2573
A simple, versatile, and general approach to the solution phase, parallel synthesis of chemical libraries conducted on a generalized or universal template, which allows the preparation of multi-mil...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9f8afafe2e4745c6682a872f85966b4
https://doi.org/10.1021/ja9530681
https://doi.org/10.1021/ja9530681
Autor:
Soan Cheng, Daniel D. Comer
Publikováno v:
Tetrahedron Letters. 43:1179-1181
A novel strategy for the synthesis of 3-sulfanylsubstituted 1-(arylamino)-pyrrolidine-2,5-dione derivatives via the alumina-catalyzed Michael addition of mercaptans to N-anilinomaleimides is described. The utilization of alumina in the synthesis offe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c35878b7111afdf6498571cda11717
https://doi.org/10.1016/s0040-4039(01)02401-7
https://doi.org/10.1016/s0040-4039(01)02401-7
Publikováno v:
ChemInform. 27
A simple, versatile, and general approach to the solution phase, parallel synthesis of chemical libraries conducted on a generalized or universal template, which allows the preparation of multi-mil...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19255d5483c3a2a6edf8dd2b2bde4261
https://doi.org/10.1002/chin.199630094
https://doi.org/10.1002/chin.199630094
Autor:
Daniel D. Comer, Soan Cheng
Publikováno v:
ChemInform. 33
A novel strategy for the synthesis of 3-sulfanylsubstituted 1-(arylamino)-pyrrolidine-2,5-dione derivatives via the alumina-catalyzed Michael addition of mercaptans to N-anilinomaleimides is described. The utilization of alumina in the synthesis offe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba160df4c06608a0859adaffa85db0e4
https://doi.org/10.1002/chin.200221082
https://doi.org/10.1002/chin.200221082
Autor:
Stacie A. Dalrymple, Rick Roberts, Kyung Song, Mcintosh Joel, Jennifer L. Miller, Julie Lim, Pete William Dunten, Florentino Sanpablo, Paul Weller, Phyllis E. Whiteley, Lu Zeng, Jose Freire-Moar, Armando G. Villaseñor, Humberto Bartolome Arzeno, David Michael Goldstein, JoAnn LaFargue, Deborah Carol Reuter, Stephen D. Warren, Brett Lovejoy, Sushmita Chanda, Saunders John, Alejandra Trejo, Daniel D. Comer, Michelle F. Browner, Mary Welch, Soan Cheng, Eva Papp
Publikováno v:
Journal of medicinal chemistry. 46(22)
Inhibition of the biosynthesis of proinflammatory cytokines such as tumor necrosis factor and interleukin-1 via p38 has been an approach toward the development of a disease modifying agent for the treatment of chronic inflammation and autoimmune dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d474cd0f78f5831f3f3fdd0cbfb5515f
https://pubmed.ncbi.nlm.nih.gov/14561090
https://pubmed.ncbi.nlm.nih.gov/14561090
Autor:
Dale L. Boger, Peter Myers, Soan Cheng, Daniel D. Comer, Lynn Helena Caporale, Christine M. Tarby, John P. Williams
Publikováno v:
Bioorganicmedicinal chemistry. 4(5)
A general approach to the solution phase, parallel synthesis of chemical libraries, which allows the preparation of multi-milligram quantities of each individual member, is exemplified with both a universal and dipeptide mimetic template. In each ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95c2dc7cae16fac457b14fa000c58af
https://pubmed.ncbi.nlm.nih.gov/8804539
https://pubmed.ncbi.nlm.nih.gov/8804539