Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Daniel D. Long"'
Autor:
David Beattie, Jacobsen John R, Glenmar P. Obedencio, Scott R. Armstrong, Timothy J. Church, Daniel D. Long, Ross G. Vickery, Pamela R. Tsuruda, Pierre-Jean Colson, Christina B. Campbell, Stergiades Ioanna, Miroslav Rapta, Dalziel Sean M, Daisuke Saito, Priscilla Van Dyke, Lan Jiang
Publikováno v:
ACS Med Chem Lett
[Image: see text] The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed to a growing opioid epidemic in the United
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eb2998f1bc2f55f8f113199e7df461
https://europepmc.org/articles/PMC6912869/
https://europepmc.org/articles/PMC6912869/
Autor:
Daniel D. Long, Samuel Kintz, Lan Jiang, Ross G. Vickery, David Beattie, Daisuke Saito, Stergiades Ioanna, Jacobsen John R, Glenmar P. Obedencio
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(13)
Gastrointestinal dysfunction as a consequence of the use of opioid analgesics is of significant clinical concern. First generation drugs to treat these opioid-induced side-effects were limited by their negative impact on opioid receptor agonist-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f247f59fe80eece43e453df2431f10ec
https://pubmed.ncbi.nlm.nih.gov/28499731
https://pubmed.ncbi.nlm.nih.gov/28499731
Autor:
Jeng-Pyng Shaw, Daniel Marquess, R. Murray McKinnell, Paul R. Fatheree, David Beattie, Scott R. Armstrong, Daniel D. Long, Ross G. Vickery
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4210-4215
The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the benzimidazole ring led to a series of agonists with subnanomolar binding affinity and mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0643983a830ed44b26b2d665107333f
https://doi.org/10.1016/j.bmcl.2013.05.018
https://doi.org/10.1016/j.bmcl.2013.05.018
Autor:
Daniel D. Long, Scott R. Armstrong, David Beattie, Carrie Richardson, Sharath S. Hegde, Christina B. Campbell, Ross G. Vickery, Pamela R. Tsuruda
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 386:471-478
The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development for the treatment of opioid-induced constipation, was compared to that of the clinically studied opioid antagonists, naltre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67dda43c21d81ff8abfbc1c7827bc1e
https://doi.org/10.1007/s00210-013-0844-5
https://doi.org/10.1007/s00210-013-0844-5
Autor:
Samuel Kintz, Sharath S. Hegde, Daniel D. Long, Daniel Marquess, Lan Jiang, Hans E. Purkey, Craig M. Hill, Michael S. Wilson, Jeng-Pyng Shaw, Kevin Wrench, Bryan A. Frieman, Tod Steinfeld
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:939-943
Lowering of intra-ocular pressure is the primary pharmacologic approach for the treatment of glaucoma and a number of distinct mechanisms of action have been clinically validated. Targeting of multiple mechanisms in combination therapies has proven e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bee4304aedc7006847daaccce1feab8
https://doi.org/10.1016/j.bmcl.2012.12.058
https://doi.org/10.1016/j.bmcl.2012.12.058
Autor:
George W. J. Fleet, David R. Brown, Helen Ardron, Thomas Martin Krulle, Benjamin L. Davis, Neil A. Hindle, Daniel G. Marquess, Daniel D. Long, Alexandra L. Lane, Colin Smith, David J. Watkin
Displacement of α-triflates of 2,3,4-all cis-substituted γ-lactones by sodium azide in DMF gives kinetically an azide with inversion of configuration at the C-2 of the lactone; under the reaction conditions, the initially formed azide epimerises to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7bc39733cd0fa1b2dcadbfade593f7
https://doi.org/10.1039/cc9960001271
https://doi.org/10.1039/cc9960001271
Autor:
Martin D. Smith, George W. J. Fleet, Timothy D. W. Claridge, Daniel G. Marquess, Daniel D. Long, Angeles Martín
Whereas trimers and tetramers of β- C - d -arabinofuranosyl carbohydrate amino acids adopt well defined conformations based around a repeating β-turn like structure, stabilised by (i, i-2) inter-residue hydrogen bonds, there is no indication of any
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c9de6aa1bf7f208f92776f9da85141
https://doi.org/10.1016/s0040-4039(99)00109-4
https://doi.org/10.1016/s0040-4039(99)00109-4
Autor:
John L. Pace, Kevin M. Krause, J. Kevin Judice, Burton G. Christensen, James B. Aggen, Daniel D. Long, Koné Kaniga, Martin S. Linsell, Sharath S. Hegde, Edmund J. Moran
Publikováno v:
The Journal of Antibiotics. 61:595-602
The design, synthesis and antibacterial activity of novel glycopeptide/beta-lactam heterodimers is reported. Employing a multivalent approach to drug discovery, vancomycin and cephalosporin synthons, A and B respectively, were chemically linked to yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2f187fdf5024f80b2cf483e377057f
https://doi.org/10.1038/ja.2008.79
https://doi.org/10.1038/ja.2008.79
Autor:
Long Mao, Daniel D. Long, Corey Anderson, Catherine Jolivet, Michele Ramirez-Weinhouse, Christine M. Crane, Andreas P. Termin, Dean M. Wilson, Valentina Molteni, Dewey Fanning
Publikováno v:
Synlett. 24:2140-2142
A two-step reaction sequence yielding 2-aminooxazolines under mild conditions was developed. Both electron-rich and electron-deficient styrenes as well as functionalized primary and secondary amides could be used in the reaction to afford 2-aminooxaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb163e88edee948c7bed583670d51a49
https://doi.org/10.1055/s-0033-1339652
https://doi.org/10.1055/s-0033-1339652
Autor:
Andreas P. Termin, Daniel D. Long
Publikováno v:
Tetrahedron Letters. 41:6743-6747
The efficient synthesis of a novel endocyclic sulfonamide template via a ring-closing metathesis methodology is reported. A solid-supported variant of the Grubbs catalyst is shown to be effective and the suitability of the template for both combinato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0df800c5f240596061b62f775b6aaec6
https://doi.org/10.1016/s0040-4039(00)01167-9
https://doi.org/10.1016/s0040-4039(00)01167-9