Zobrazeno 1 - 10
of 462
pro vyhledávání: '"Daniel D Billadeau"'
Autor:
Xingxing Zhu, Yue Wu, Yanfeng Li, Xian Zhou, Jens O. Watzlawik, Yin Maggie Chen, Ariel L. Raybuck, Daniel D. Billadeau, Virginia Smith Shapiro, Wolfdieter Springer, Jie Sun, Mark R. Boothby, Hu Zeng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Germinal center (GC) formation, which is an integrant part of humoral immunity, involves energy-consuming metabolic reprogramming. Rag-GTPases are known to signal amino acid availability to cellular pathways that regulate nutrient distributi
Externí odkaz:
https://doaj.org/article/b9a0aef0153c41448af1034c22be9cab
Autor:
Zehua Shang, Sitao Zhang, Jinrui Wang, Lili Zhou, Xinyue Zhang, Daniel D. Billadeau, Peiguo Yang, Lingqiang Zhang, Fangfang Zhou, Peng Bai, Da Jia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Stress granules (SGs) are induced by various environmental stressors, resulting in their compositional and functional heterogeneity. SGs play a crucial role in the antiviral process, owing to their potent translational repressive effects and
Externí odkaz:
https://doaj.org/article/2a58307d4cc34ed0be0b78ff8fafa5ff
Autor:
Daheui Choi, Alan M. Gonzalez‐Suarez, Mihai G. Dumbrava, Michael Medlyn, Jose M. deHoyos‐Vega, Frank Cichocki, Jeffrey S. Miller, Li Ding, Mojun Zhu, Gulnaz Stybayeva, Alexandre Gaspar‐Maia, Daniel D. Billadeau, Wen Wee Ma, Alexander Revzin
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Patient‐derived cancer organoids (PDOs) hold considerable promise for personalizing therapy selection and improving patient outcomes. However, it is challenging to generate PDOs in sufficient numbers to test therapies in standard culture p
Externí odkaz:
https://doaj.org/article/8bace5ec4db746318ee3c8614e155c51
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/d74245a793254efda9f775fe59b1befc
Autor:
Matthew J. Wiest, Laurie Baert, Chao Gu, Kevin M. Gayler, Hyoungjun Ham, Laurent Gorvel, Mira T. Keddis, Leroy W. Griffing, HyeMee Joo, Jean-Pierre Gorvel, Daniel D. Billadeau, Robert R. Kane, SangKon Oh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Plasmacytoid dendritic cells (pDC) are the major producer of type 1 IFN in response to TLR7 agonists. Aberrant TLR7 activation and type 1 IFN expression by pDCs are linked to the pathogenesis of certain types of autoimmune diseases, including systemi
Externí odkaz:
https://doaj.org/article/84b0569564b24006ad6f0204bb420e8c
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Spontaneous dimerization of EGF receptors (EGFR) and dysregulation of EGFR signaling has been associated with the development of different cancers. Under normal physiological conditions and to maintain homeostatic cell growth, once EGFR signaling occ
Externí odkaz:
https://doaj.org/article/841b3f670036419ba8b9fcc73345e212
Autor:
Jennifer L. Johnson, Elsa Meneses-Salas, Mahalakshmi Ramadass, Jlenia Monfregola, Farhana Rahman, Raquel Carvalho Gontijo, William B. Kiosses, Kersi Pestonjamasp, Dale Allen, Jinzhong Zhang, Douglas G. Osborne, Yanfang Peipei Zhu, Nathan Wineinger, Kasra Askari, Danni Chen, Juan Yu, Scott C. Henderson, Catherine C. Hedrick, Matilde Valeria Ursini, Sergio Grinstein, Daniel D. Billadeau, Sergio D. Catz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Responsive exocytosis in neutrophil leukocytes involves actin depolymerisation-dependent sequential release of gelatinase granules, then strongly pro-inflammatory azurophilic granules. Here authors show that the actin nucleator protein WASH facilitat
Externí odkaz:
https://doaj.org/article/9638c498eebb49f28ed25260528bc5a9
Publikováno v:
MedComm – Oncology, Vol 2, Iss 2, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/9ccd140c72824a1eb23fcfa4fe029579
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/d25291c81e4045e1b54911b44b58f851
Autor:
Matthew J. Wiest, Chao Gu, Hyoungjun Ham, Laurent Gorvel, Mira T. Keddis, Leroy W. Griffing, HyeMee Joo, Jean-Pierre Gorvel, Daniel D. Billadeau, SangKon Oh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Plasmacytoid dendritic cells (pDCs) exhibit bifurcated cytokine responses to TLR9 agonists, an IRF7-mediated type 1 IFN response or a pro-inflammatory cytokine response via the activation of NF-κB. This bifurcated response has been hypothesized to r
Externí odkaz:
https://doaj.org/article/a8e2ddcb10aa4441a12222ee3ddd8f0b