Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Daniel C. Marcus"'
Autor:
Kyunghee X Kim, Joel D Sanneman, Hyoung-Mi Kim, Donald G Harbidge, Jie Xu, Manoocher Soleimani, Philine Wangemann, Daniel C Marcus
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97191 (2014)
Several members of the SLC26 gene family have highly-restricted expression patterns in the auditory and vestibular periphery and mutations in mice of at least two of these (SLC26A4 and SLC26A5) lead to deficits in hearing and/or balance. A previous r
Externí odkaz:
https://doaj.org/article/a4af9d3081b24515b3e3cae7919f4d65
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65977 (2013)
Slc26a4 (Δ/Δ) mice are deaf, develop an enlarged membranous labyrinth, and thereby largely resemble the human phenotype where mutations of SLC26A4 cause an enlarged vestibular aqueduct and sensorineural hearing loss. The enlargement is likely cause
Externí odkaz:
https://doaj.org/article/af1fbac376ce454f9821a1348def763e
Autor:
Xiangming Li, Joel D Sanneman, Donald G Harbidge, Fei Zhou, Taku Ito, Raoul Nelson, Nicolas Picard, Régine Chambrey, Dominique Eladari, Tracy Miesner, Andrew J Griffith, Daniel C Marcus, Philine Wangemann
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003641 (2013)
Mutations of SLC26A4 are a common cause of human hearing loss associated with enlargement of the vestibular aqueduct. SLC26A4 encodes pendrin, an anion exchanger expressed in a variety of epithelial cells in the cochlea, the vestibular labyrinth and
Externí odkaz:
https://doaj.org/article/a86719aa2c854770b010a3f7775fd156
Autor:
Daniel C. Marcus
Publikováno v:
Ion Transport Across Epithelial Tissues and Disease ISBN: 9783030553098
The sensory functions of the auditory and vestibular peripheral organs (inner ear) depend on vigorous transepithelial ion transport processes under the control of hormones and other signal pathways. The most salient of these are secretion of K+ and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f11b94cf9fd7d2decde750c4bc73fed7
https://doi.org/10.1007/978-3-030-55310-4_8
https://doi.org/10.1007/978-3-030-55310-4_8
Autor:
Yoko Nakano, Sung H Kim, Hyoung-Mi Kim, Joel D Sanneman, Yuzhou Zhang, Richard J H Smith, Daniel C Marcus, Philine Wangemann, Randy A Nessler, Botond Bánfi
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000610 (2009)
Hereditary hearing loss is one of the most common birth defects, yet the majority of genes required for audition is thought to remain unidentified. Ethylnitrosourea (ENU)-mutagenesis has been a valuable approach for generating new animal models of de
Externí odkaz:
https://doaj.org/article/1b9a3b3baad949b3899ccb9bee4212da
Autor:
Daniel C. Marcus, Donald G. Harbidge, Tabita Kreko-Pierce, Nina Boiko, James D. Stockand, Jason R. Pugh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Unipolar brush cells (UBCs) are excitatory granular layer interneurons in the vestibulocerebellum. Here we assessed motor coordination and balance to investigate if deletion of acid-sensing ion channel 5 (Asic5), which is richly expressed in type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25bcdaf3e5910a574b6780256b45a19
https://pubmed.ncbi.nlm.nih.gov/32034189
https://pubmed.ncbi.nlm.nih.gov/32034189
Autor:
Daniel C. Marcus, Jae Young Choi, Jinsei Jung, Jin Young Kim, Junhui Jeong, Sung Huhn Kim, Philine Wangemann, Hansol Hong
Publikováno v:
Hearing Research. 386:107860
Purinergic receptors protect the cochlea during high-intensity stimulation by providing a parallel shunt pathway through non-sensory neighboring epithelial cells for cation absorption. So far, there is no direct functional evidence for the presence a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0624b3c589cb30822f4ccb29cfaa0fd
https://doi.org/10.1016/j.heares.2019.107860
https://doi.org/10.1016/j.heares.2019.107860
Publikováno v:
BMC Physiology
BMC Physiology, Vol 18, Iss 1, Pp 1-8 (2018)
BMC Physiology, Vol 18, Iss 1, Pp 1-8 (2018)
Background Claudins are major components of tight junctions, which form the paracellular barrier between the cochlear luminal and abluminal fluid compartments that supports the large transepithelial voltage difference and the large concentration diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1901b212225b0d6c51405b9bd844ef
https://doi.org/10.1186/s12899-018-0035-1
https://doi.org/10.1186/s12899-018-0035-1
Autor:
Philine Wangemann, Daniel C. Marcus
Publikováno v:
Understanding the Cochlea ISBN: 9783319520711
The transduction of sound into nerve impulses requires an ionic environment that depends on a variety of ion transport processes in epithelial and endothelial cells of the cochlea. Specific ion transport functions occur in specific cell types that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a931d471b42351d224711ae7eb2c1f
https://doi.org/10.1007/978-3-319-52073-5_9
https://doi.org/10.1007/978-3-319-52073-5_9
Autor:
Douglas Forrest, Xiangming Li, David S. Sharlin, Philine Wangemann, Hyoung-Mi Kim, Daniel C. Marcus, Ruchira Singh, Sara E. Billings, Peying Fong, Kazuhiro Nakaya
Publikováno v:
American Journal of Physiology-Renal Physiology
Mutations of SLC26A4 cause an enlarged vestibular aqueduct, nonsyndromic deafness, and deafness as part of Pendred syndrome. SLC26A4 encodes pendrin, an anion exchanger located in the cochlea, thyroid, and kidney. The goal of the present study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53acfdaf6d29410843b46fcde9c08f17