Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daniel C. Lowes"'
Autor:
Daniel C. Lowes, Linda A. Chamberlin, Lisa N. Kretsge, Emma S. Holt, Atheir I. Abbas, Alan J. Park, Lyubov Yusufova, Zachary H. Bretton, Ayesha Firdous, Armen G. Enikolopov, Joshua A. Gordon, Alexander Z. Harris
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts re
Externí odkaz:
https://doaj.org/article/00c4ef5a5a704504b5b5820961797043
Autor:
Kelly M Martyniuk, Arturo Torres-Herraez, Daniel C Lowes, Marcelo Rubinstein, Marie A Labouesse, Christoph Kellendonk
Publikováno v:
eLife, Vol 11 (2022)
In the striatum, acetylcholine (ACh) neuron activity is modulated co-incident with dopamine (DA) release in response to unpredicted rewards and reward-predicting cues and both neuromodulators are thought to regulate each other. While this co-regulati
Externí odkaz:
https://doaj.org/article/c1da0dccdc9e4a8580337b1bf977c1fc
Autor:
Lyubov Yusufova, Ayesha Firdous, Daniel C. Lowes, Lisa N. Kretsge, Emma S Holt, Alexander Z. Harris, Alan J. Park, Linda A. Chamberlin, Joshua A. Gordon, Armen G. Enikolopov, Zachary H. Bretton, Atheir I. Abbas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Decreased pleasure-seeking (anhedonia) forms a core symptom of depression. Stressful experiences precipitate depression and disrupt reward-seeking, but it remains unclear how stress causes anhedonia. We recorded simultaneous neural activity across li
Autor:
Chia-Yuan Chang, Daniel C. Lowes, Alan J. Park, Joshua A. Gordon, Atheir I. Abbas, Christoph Kellendonk, Alexander Z. Harris, Kelly M. Martyniuk, Joseph A. Gogos
Publikováno v:
Nature. 591:615-619
The ability to rapidly adapt to novel situations is essential for survival, and this flexibility is impaired in many neuropsychiatric disorders1. Thus, understanding whether and how novelty prepares, or primes, brain circuitry to facilitate cognitive
Autor:
Richard Warren, Daniel C. Lowes, Arjun V. Masurkar, David H. Brann, Isabel Reyes, Steven A. Siegelbaum, Chengju Tian
Publikováno v:
J Neurophysiol
The population activity of CA1 pyramidal neurons (PNs) segregates along anatomical axes with different behaviors, suggesting that CA1 PNs are functionally subspecialized based on somatic location. In dorsal CA1, spatial encoding is biased toward CA2
Autor:
Daniel C. Lowes, Alexander Z. Harris
Publikováno v:
Neuron. 109:1250-1252
Summary In this issue of Neuron, Bitzenhofer et al. show that transiently stimulating the prefrontal cortex during a brief critical window early in development causes precocious maturation and lasting deleterious consequences on circuit activity and
Autor:
Daniel C. Lowes, Alexander Z. Harris
Publikováno v:
Curr Opin Endocr Metab Res
Stress affects many brain regions, including the ventral tegmental area (VTA), which is critically involved in reward processing. Excessive stress can reduce reward-seeking behaviors but also exacerbate substance use disorders, two seemingly contradi
Autor:
Kretsge Ln, Daniel C. Lowes, Alan J. Park, Zachary H. Bretton, Chamberlin La, Yusufova L, Emma S Holt, Alexander Z. Harris, Firdous A, Atheir I. Abbas, Joshua A. Gordon
Stressful experiences frequently precede depressive episodes1. Depression results in anhedonia, or disrupted reward-seeking, in most patients2. In humans3,4 and rodents5,6, stress can disrupt reward-seeking, providing a potential mechanism by which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8f6516cea0837112482ad01450796a9
https://doi.org/10.1101/2020.05.28.121905
https://doi.org/10.1101/2020.05.28.121905
Autor:
David H. Brann, Arjun V. Masurkar, Steven A. Siegelbaum, Richard Warren, Daniel C. Lowes, Kalyan V. Srinivas
Publikováno v:
Cell Reports. 18:148-160
Although hippocampal CA1 pyramidal neurons (PNs) were thought to comprise a uniform population, recent evidence supports two distinct sublayers along the radial axis, with deep neurons more likely to form place cells than superficial neurons. CA1 PNs