The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells.

Autor: Edmond F O'Donnell, Prasad Rao Kopparapu, Daniel C Koch, Hyo Sang Jang, Jessica Lynne Phillips, Robert L Tanguay, Nancy I Kerkvliet, Siva Kumar Kolluri

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40926 (2012)

A novel role of the dihydroorotatedehydrogenase (DHODH) inhibitor leflunomide as a potential anti-melanoma therapy was recently reported (Nature 471:518-22, 2011). We previously reported that leflunomide strongly activates the transcriptional activit

Externí odkaz: https://doaj.org/article/ca4c067be86c4cbb82572b155e28740e

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Autor: Dustin G. Brown, Tove Hultman, Judith Weisz, H. Kim Lyerly, Paola A. Marignani, Ann-Karin Olsen, Rabindra Roy, Kim Moorwood, Masoud H. Manjili, Monica Vaccari, Jesse Roman, Hasiah Ab Hamid, Kalan R. Prudhomme, Periyadan K. Krishnakumar, Chenfang Dong, Tiziana Guarnieri, Leandro S. D'Abronzo, Gloria M. Calaf, Amelia K Charles, Emanuela Corsini, Yunus A. Luqmani, Graeme Williams, Louis Vermeulen, Pankaj Vadgama, Sarah N Bay, Véronique Maguer-Satta, Sabine A. S. Langie, Christian C. Naus, Le Jian, Gladys N. Nangami, Lorenzo Memeo, Stephanie C. Casey, Thomas Sanderson, Takemi Otsuki, Nichola Cruickshanks, William H. Bisson, Sudjit Luanpitpong, Jonathan Whitfield, Ahmed Lasfar, Yon Rojanasakul, A. Ivana Scovassi, Shelley A. Harris, Ferdinando Chiaradonna, Richard Ponce-Cusi, Gregory T. Wolf, Valérian Dormoy, Roslida Abd Hamid, Hyun Ho Park, Matilde E. Lleonart, William K. Decker, Maria Romano, Leroy Lowe, Fabio Marongiu, Jan Vondráček, Chiara Mondello, Luc Leyns, Josiah Ochieng, Pratima Nangia-Makker, Edward A. Ratovitski, Zhiwei Hu, Jayadev Raju, Hemad Yasaei, Rafaela Andrade-Vieira, Jordan Woodrick, Hideko Sone, Harini Krishnan, W. Kimryn Rathmell, Andrew Collins, Luoping Zhang, Barry J. Barclay, Amaya Azqueta, Laura Soucek, Marc A. Williams, David O. Carpenter, Roberta Palorini, Rita Nahta, Juan Fernando Martinez-Leal, Firouz Darroudi, Rita Dornetshuber-Fleiss, James E. Klaunig, Elizabeth P. Ryan, Qiang Shawn Cheng, Arthur Berg, Andrew Ward, Gudrun Koppen, Tao Chen, Petr Heneberg, Michael Gilbertson, Amedeo Amedei, Sakina E. Eltom, Ezio Laconi, Joseph Christopher, Hiroshi Kondoh, Neetu Singh, Danielle J Carlin, Marion Chapellier, Michalis V. Karamouzis, Rekha Mehta, Tae-Jin Lee, Annamaria Colacci, Venkata S. Sabbisetti, Mark Wade, Micheline Kirsch-Volders, Patricia Ostrosky-Wegman, Isabelle R. Miousse, Patricia A. Thompson, Philippa D. Darbre, Frederik J. van Schooten, Sofia Pavanello, Igor Koturbash, Binhua P. Zhou, Ranjeet Kumar Sinha, Anna C. Salzberg, Mahara Valverde, Fahd Al-Mulla, Julia Kravchenko, Nicole Kleinstreuer, Carolyn J. Baglole, Menghang Xia, Samira A. Brooks, Amancio Carnero, Gunnar Brunborg, Sandra S. Wise, Daniel C. Koch, John Pierce Wise, Rabeah Al-Temaimi, Laetitia Gonzalez, Lisa J. McCawley, R. Brooks Robey, Gary S. Goldberg, Thierry Massfelder, Linda S M Gulliver, Olugbemiga Ogunkua, Emilio Rojas, Eun-Yi Moon, Lin Li, Silvana Papagerakis, Nik van Larebeke, Adela Lopez de Cerain Salsamendi, Staffan Eriksson, Simona Romano, Dean W. Felsher, Paramita M. Ghosh, Karine A. Cohen-Solal, Paul Dent, Jun Sun, Carmen Blanco-Aparicio, Riccardo Di Fiore, Chia-Wen Hsu, Mahin Khatami, Kannan Badri Narayanan, Francis Martin, Colleen S. Curran, Dale W. Laird, William H. Goodson, Abdul Manaf Ali, Valerie Odero-Marah, Michael J. Gonzalez, Renza Vento, Liang Tzung Lin, Clement G. Yedjou, Hosni Salem, Hsue-Yin Hsu, Zhenbang Chen, Nuzhat Ahmed, Gerard Wagemaker, Sandra Ryeom, Stefano Forte, Debasish Roy, Nancy B. Kuemmerle, Robert C. Castellino, Po Sing Leung, Wilhelm Engström

Publikováno v: Carcinogenesis, 36 Suppl 1, S254-S296. Oxford University Press
Carcinogenesis
Carcinogenesis, Oxford University Press (OUP), 2015, 36 (Suppl 1), pp.S254-96. ⟨10.1093/carcin/bgv039⟩
Carcinogenesis, 2015, 36 (Suppl 1), pp.S254-96. ⟨10.1093/carcin/bgv039⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname

Goodson, William H. et al.
© The Author 2015. Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5823ab67c1d978d35e01104f2396538
https://doi.org/10.1093/carcin/bgv039

The effect of environmental chemicals on the tumor microenvironment

Autor: Fahd Al-Mulla, Laura Soucek, Dustin G. Brown, Lorenzo Memeo, A. Ivana Scovassi, Louis Vermeulen, Stefano Forte, Periyadan K. Krishnakumar, William H. Bisson, Jayadev Raju, Jordan Woodrick, Dean W. Felsher, Fabio Marongiu, Rabeah Al-Temaimi, Monica Vaccari, Sandra Ryeom, Jesse Roman, Jonathan Whitfield, Roslida Abd Hamid, Annamaria Colacci, Amedeo Amedei, Petr Heneberg, Hosni Salem, Colleen S. Curran, Daniel C. Koch, Rabindra Roy, Véronique Maguer-Satta, Stephanie C. Casey, Neetu Singh, Chiara Mondello, Mary Helen Barcellos-Hoff, Elizabeth P. Ryan, Joseph Christopher, Marion Chapellier, Ezio Laconi

Publikováno v: Carcinogenesis, vol 36 Suppl 1, iss Suppl 1

Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e870d4b1a3a81dd09618f49fa92d23
https://escholarship.org/uc/item/5hb135r8

The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells

Autor: Nancy I. Kerkvliet, Edmond F. O’Donnell, Prasad Rao Kopparapu, Hyo Sang Jang, Robert L. Tanguay, Siva Kumar Kolluri, Daniel C. Koch, Jessica Lynne Phillips

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e40926 (2012)

A novel role of the dihydroorotatedehydrogenase (DHODH) inhibitor leflunomide as a potential anti-melanoma therapy was recently reported (Nature 471:518-22, 2011). We previously reported that leflunomide strongly activates the transcriptional activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f4a91d6b071819a514dcdc74e73dba
https://pubmed.ncbi.nlm.nih.gov/22815870

The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor

Autor: Lijoy K. Mathew, Katerine S. Saili, Robert L. Tanguay, Prasad Rao Kopparapu, Daniel C. Koch, David G. Farrer, Siva Kumar Kolluri, Edmond F. O’Donnell, William H. Bisson, Sumitra Sengupta, Nancy I. Kerkvliet

Publikováno v: PLoS ONE, Vol 5, Iss 10 (2010)
PLoS ONE

Background The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related chemicals. The AhR influences a variety of processes involved in cellular growth and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a7a71eb65e84a0b9097f8c34856eee
https://doi.org/10.1371/journal.pone.0013128