Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease

Autor: Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar

Publikováno v: Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)

Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem

Externí odkaz: https://doaj.org/article/85ceab688bb44f7d8336a4d35cb11973

Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting

Autor: Kevin C. Allan, Tyler E. Miller, Andrew R. Morton, Marissa A. Scavuzzo, Matthew S. Elitt, Benjamin L.L. Clayton, Lucille R. Hu, Jost K. Vrabic, Hannah E. Olsen, Daniel C. Factor, Jonathan E. Henninger, Richard A. Young, Charles Y. Lin, Peter C. Scacheri, Paul J. Tesar

SUMMARYPluripotent stem cells (PSCs) provide an unlimited source for generating somatic cell types. However, generating fully mature cells constitutes a bottleneck for realizing their full potential in research and medicine. Here, we report a transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ee17af1d86d3aea0ee785bea3821dc2
https://doi.org/10.1101/2022.11.17.516981

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

Autor: William K. Wilson, Matthew S. Elitt, Dharmaraja Allimuthu, Paul J. Tesar, Ilya Bederman, Mayur Madhavan, Franz Bracher, H. Elizabeth Shick, Martin Giera, Joel L. Sax, Jing Jin, Yuriy Fedorov, Eric Garrison, Zita Hubler, Drew J. Adams, Kevin C. Allan, Robert H. Miller, Daniel C. Factor, Matthew A. Thompson, Molly Karl, Zachary S. Nevin

Publikováno v: Nature, 560(7718), 372
Nature

Regeneration of myelin is mediated by oligodendrocyte progenitor cells (OPCs), an abundant stem cell population in the CNS and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the central nervous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bd92c8bbc40fd074b077d070760713
https://doi.org/10.1038/s41586-018-0360-3

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Autor: Anne Song, Alexander J. Federation, Leo J.Y. Kim, David T.W. Jones, Ana Fernandez Miñan, Laura McDonald, Mathieu Lupien, Susan Q. Ke, Lukas Chavez, Briana C. Prager, Sheila K. Singh, Peter B. Dirks, Borja L. Holgado, Kristian W. Pajtler, Yan Li, Till Milde, Marc Zapatka, Angel M. Carcaboso, Livia Garzia, Xiuxing Wang, Chao Jun Li, Kenneth Aldape, Christine Lee, Ian C. Scott, Xin Wang, Laura K. Donovan, Xiu-Wu Bian, Sylvia Doan, Stephen M. Dombrowski, Betty Luu, Michael D. Taylor, Adam Tropper, Vaidehi Mahadev, James E. Bradner, Ryan C. Gimple, Tyler E. Miller, Serap Erkek, Christopher G. Hubert, Daniel C. Factor, Kulandaimanuvel Antony Michaelraj, Stefan M. Pfister, Kelsey C. Bertrand, Jennifer Zuccaro, Zhiqin Huang, Yuan Yao Thompson, Hendrik Witt, Nada Jabado, Konstantin Okonechnikov, Paul A. Northcott, James J. Morrow, Senthuran Vijayarajah, Jeremy N. Rich, Susanne Gröbner, Andrey Korshunov, Vijay Ramaswamy, Sisi Lai, Stephen C. Mack, Alina Saiakhova, Annie Huang, Claudia L.L. Valentim, James T. Rutka, Eric Bouffet, Xiaochong Wu, Matthias Lienhard, Qiulian Wu, Jüri Reimand, Peter J. Houghton, Andrew R. Morton, Peter C. Scacheri, John J.Y. Lee, Marina Ryzhova, Patrick Sin-Chan, Peter Lichter, Stephen T. Keir, Marcel Kool

Publikováno v: Nature
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many malignancies remain unknown or non-targetable, so alternative approaches to the identification of therapeutic leads are necessary. Ependymomas are ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14b43b01c6fec382bc89e653995fb58
https://doi.org/10.1038/nature25169

RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation

Autor: Xiuxing Wang, Tyler E. Miller, Brian B. Liau, Qiulian Wu, Daniel C. Factor, Leo J.Y. Kim, Shideng Bao, Wenchao Zhou, Kailin Yang, Bradley E. Bernstein, Jeremy N. Rich, Kareem Alazem, Xiaoguang Fang, Zhi Huang, Stephen C. Mack, Qi Xie

Publikováno v: Journal of Clinical Investigation. 126:2757-2772

Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumor-initiating cells (BTICs), also known as cancer stem cells. NOTCH signaling has been a molecular target in BTICs, but NOTCH antagonists have demonstrated limited efficacy in cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a14b0ade9ce38676f7dcd91a411abe8
https://doi.org/10.1172/jci86114