Výsledky vyhledávání - "Daniel C. Colvin"

Data from EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer

Autor: Jin Chen, Nathanael S. Gray, William Pao, Justin M. Cates, Daniel C. Colvin, Justin M. Balko, Pengcheng Lu, Fei Ye, Catherine B. Meador, Christine M. Lovly, Wenqiang Song, Andrew K. Hastings, Li Tan, Shan Wang, Katherine R. Amato

Despite the success of treating EGFR-mutant lung cancer patients with EGFR tyrosine kinase inhibitors (TKI), all patients eventually acquire resistance to these therapies. Although various resistance mechanisms have been described, there are currentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819fa9da92ef1aeb53f45437b717aa9e
https://doi.org/10.1158/0008-5472.c.6507648

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Supplemental Figures S1-S6 from EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer

Localization of EPHA2 in erlotinib resistant cells (S1); Validation of EPHA2 antibody specificity in patient tumor specimens (S2); EPHA2 kinase activity is required in maintaining cell viability of erlotinib resistant lung cancer (S3); Biochemical an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3520c0d40f30a9b0d77dbdda083d08
https://doi.org/10.1158/0008-5472.22408941.v1

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Spin‐lock relaxation rate dispersion reveals spatiotemporal changes associated with tubulointerstitial fibrosis in murine kidney

Autor: Suwan Wang, Hua Li, Feng Wang, Ming-Zhi Zhang, Daniel C. Colvin, Zhongliang Zu, Raymond C. Harris, John C. Gore

Publikováno v: Magn Reson Med

PURPOSE: To develop and evaluate a reliable non-invasive means for assessing the severity and progression of fibrosis in kidneys. We employed spin-lock MR imaging with different locking fields to detect and characterize progressive renal fibrosis in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a21840da11f60d206fb98daedc34e92
https://doi.org/10.1002/mrm.28230

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Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics

Autor: Jing Liu, Elaine L. Shelton, Rachelle Crescenzi, Daniel C. Colvin, Annet Kirabo, Jianyong Zhong, Eric J. Delpire, Hai-Chun Yang, Valentina Kon

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1428, p 1428 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1428

Lymphatic vessels are highly responsive to changes in the interstitial environment. Previously, we showed renal lymphatics express the Na-K-2Cl cotransporter. Since interstitial sodium retention is a hallmark of proteinuric injury, we examined whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bb873594f0527a619047ffc1c486ad
https://www.mdpi.com/1422-0067/23/3/1428

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Renal tubular dilation and fibrosis after unilateral ureter obstruction revealed by relaxometry and spin-lock exchange MRI

Autor: Raymond C. Harris, Tadashi Otsuka, Keiko Takahashi, Chikage Narui, John C. Gore, Takamune Takahashi, Daniel C. Colvin, Feng Wang

Publikováno v: NMR in biomedicineREFERENCES. 34(8)

We evaluated the use of quantitative MRI relaxometry, including the dispersion of spin-lock relaxation with different locking fields, for detecting and assessing tubular dilation and fibrosis in a mouse model of unilateral ureter obstruction (UUO). C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e059dc0e4ee79db3905f6c2e901b85be
https://pubmed.ncbi.nlm.nih.gov/33963778

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Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo

Autor: William H. Fissell, Amanda K. W. Buck, Rachel Forbes, Clark D. Kensinger, Sara B. Keller, Joseph J. Groszek, Shuvo Roy, Daniel C. Colvin, Seth J. Karp, Phillip Williams

Publikováno v: ASAIO journal (American Society for Artificial Internal Organs : 1992), vol 64, iss 2

A major challenge in developing blood-contacting medical devices is mitigating thrombogenicity of an intravascular device. Thrombi may interfere with device function or embolize from the device to occlude distant vascular beds with catastrophic conse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f611e9d9fe1ae25705c1a491dafcdf47
https://doi.org/10.1097/mat.0000000000000649

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Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities

Autor: BethAnn McLaughlin, Robert J. Singer, Moneeb Ehtesham, Daniel C. Colvin, Mitchell Odom, Imad Saeed Khan, C. Chad Quarles

Publikováno v: Journal of Neurosurgery. 125:152-159

OBJECT Matrix metalloprotease-9 (MMP-9) plays a critical role in infarct progression, blood-brain barrier (BBB) disruption, and vasogenic edema. While systemic administration of MMP-9 inhibitors has shown neuroprotective promise in ischemic stroke, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc99f07a7c1f6b068a6884ff0f52e38e
https://doi.org/10.3171/2015.4.jns142400

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Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model

Autor: Wenfu Lu, Mohammed N. Tantawy, John C. Gore, Todd E. Peterson, Daniel C. Colvin, H. Charles Manning, C. Chad Quarles, Zhenbang Chen

The identification and targeting of biomarkers specific to prostate cancer (PCa) could improve its detection. Given the high expression of translocator protein (TSPO) in PCa, we investigated the use of [18F]VUIIS1008 (a novel TSPO-targeting radioliga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18c677de58e10f5d1778d9305cbe732
https://europepmc.org/articles/PMC5903879/

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