Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Daniel C. Bittel"'
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108632- (2024)
Summary: Endurance exercise training is beneficial for skeletal muscle health, but it is unclear if this type of exercise can target or correct the molecular mechanisms of facioscapulohumeral muscular dystrophy (FSHD). Using the FLExDUX4 murine model
Externí odkaz:
https://doaj.org/article/4630d63d1e03418f9dfbcda9da3a3b78
Autor:
Daniel C. Bittel, Jyoti K. Jaiswal
Publikováno v:
Advanced Science, Vol 10, Iss 33, Pp n/a-n/a (2023)
Abstract Cells are routinely exposed to agents that cause plasma membrane (PM) injury. While pore‐forming toxins (PFTs), and chemicals cause nanoscale holes dispersed throughout the PM, mechanical trauma causes focal lesions in the PM. To examine i
Externí odkaz:
https://doaj.org/article/d1548ecbaa5d40469bb3eaa67638f3d6
Autor:
Daniel C. Bittel, Sen Chandra Sreetama, Goutam Chandra, Robin Ziegler, Kanneboyina Nagaraju, Jack H. Van der Meulen, Jyoti K. Jaiswal
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Efficient sarcolemmal repair is required for muscle cell survival, with deficits in this process leading to muscle degeneration. Lack of the sarcolemmal protein dysferlin impairs sarcolemmal repair by reducing secretion of the enzyme acid sphingomyel
Externí odkaz:
https://doaj.org/article/2286d1a20dd14e03a5b1ecfa798ba42c
Autor:
Daniel C. Bittel, Jyoti K. Jaiswal
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Skeletal myofibers are injured due to mechanical stresses experienced during physical activity, or due to myofiber fragility caused by genetic diseases. The injured myofiber needs to be repaired or regenerated to restore the loss in muscle tissue fun
Externí odkaz:
https://doaj.org/article/2eb398e4dd1f4dbf801481c7b9e0f1a8
Autor:
Adam J. Bittel, Sen Chandra Sreetama, Daniel C. Bittel, Adam Horn, James S. Novak, Toshifumi Yokota, Aiping Zhang, Rika Maruyama, Kenji Rowel Q. Lim, Jyoti K. Jaiswal, Yi-Wen Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5575 (2020)
Deficits in plasma membrane repair have been identified in dysferlinopathy and Duchenne Muscular Dystrophy, and contribute to progressive myopathy. Although Facioscapulohumeral Muscular Dystrophy (FSHD) shares clinicopathological features with these
Externí odkaz:
https://doaj.org/article/46253f1ec51248d590ae5b3a75b5c205
Autor:
Daniel C. Bittel, Goutam Chandra, Laxmi M. S. Tirunagri, Arun B. Deora, Sushma Medikayala, Luana Scheffer, Aurelia Defour, Jyoti K. Jaiswal
Publikováno v:
Cells, Vol 9, Iss 9, p 1919 (2020)
Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal
Externí odkaz:
https://doaj.org/article/2f042f974983491595d999e7337b246d
Monitoring Plasma Membrane Injury-Triggered Endocytosis at Single-Cell and Single-Vesicle Resolution
Autor:
Daniel C. Bittel, Jyoti K. Jaiswal
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627716
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cdd7025916e07f3b511860fd0dabaee
https://doi.org/10.1007/978-1-0716-2772-3_27
https://doi.org/10.1007/978-1-0716-2772-3_27
Monitoring Plasma Membrane Injury-Triggered Endocytosis at Single-Cell and Single-Vesicle Resolution
Autor:
Daniel C, Bittel, Jyoti K, Jaiswal
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2587
Plasma membrane injury activates membrane trafficking and remodeling events that are required for the injured membrane to repair. With the rapidity of the membrane repair process, the repair response needs to be monitored at high temporal and spatial
Publikováno v:
Diabetes
Two-thirds of people with type 2 diabetes mellitus (T2DM) have or will develop chronic kidney disease (CKD), which is characterized by rapid renal decline that, together with superimposed T2DM-related metabolic sequelae, synergistically promotes earl
Autor:
Mihoko Yoshino, Jun Yoshino, Gordon I. Smith, Richard I. Stein, Adam J. Bittel, Daniel C. Bittel, Dominic N. Reeds, David R. Sinacore, W. Todd Cade, Bruce W. Patterson, Kevin Cho, Gary J. Patti, Bettina Mittendorfer, Samuel Klein
Publikováno v:
Cell metabolism. 34(10)
Lifestyle therapy (energy restriction and exercise) is the cornerstone of therapy for people with type 2 diabetes (T2D) but is difficult to implement. We conducted an 8-month randomized controlled trial in persons with obesity and T2D (17 women and 1